... Eomes Brachyury Functional genetics Axis formation Cell lineage specification Tbx transcription factors Deutsche Forschungsgemeinschaft http://dx.doi.org/10.13039/501100001659 AR 732/3-1 390939984 246781735 AR 732/2-1 Sonderforschungsbereiche 89986987 431984000...

..., the identification of a planarian Src that collaborates with Wnt-dependent processes supports a potentially ancient connection between these factors for axis formation. Fig. 6. src-1 acts with Wnt and FGFRLs to control AP axis identity. Model of src-1 participating in AP patterning along with Wnts...

... signaling and regulates zebrafish axis formation by interfering with the formation of the β-catenin/Tcf transcription activation complex. EIF4A3 Wnt/β-catenin signaling β-catenin Lef/Tcf Zebrafish Axis formation Wnt/β-catenin signaling plays pivotal roles in regulating embryogenesis...

... , Xenopus and zebrafish early embryos, as well as the Drosophila wing imaginal disc and germarium. Morphogen gradient BMP patterning Zebrafish Drosophila Axis formation The core bone morphogenetic protein (BMP) signaling components are largely conserved across metazoans (reviewed...

.... Comp. Biol.   50 , 707 - 719 . 10.1093/icb/icq076 Holstein , T. W. , Watanabe , H. and Özbek , S. ( 2011 ). Signaling pathways and axis formation in the lower metazoa . Curr. Top. Dev. Biol.   97 , 137 - 177 . 10.1016/B978-0-12-385975-4.00012-7 Kiecker , C...

.... Consistent with this, overexpression of the aPKC antagonist Lgl strongly rescues the polarity defects of slmb mutant germline clones. The role of Slmb in oocyte polarity raises an intriguing parallel with C. elegans axis formation, in which PAR-2 excludes the anterior PAR complex from the posterior cortex...

... no competing financial interests. 30 10 2012 © 2013. Published by The Company of Biologists Ltd 2013 Axis formation Eye Homeodomain pbx Planarians Regeneration Fig. 7. pbx is required for maintenance of pole gene expression and eyes during homeostatic tissue turnover...

... ) Competing interests statement The authors declare no competing financial interests. 30 10 2012 © 2013. Published by The Company of Biologists Ltd Cdc42 aPKC Par-6 Bazooka Actin Polarity Oogenesis Axis formation Drosophila Cell polarity is essential...

...Shimin Lim; Pooja Kumari; Patrick Gilligan; Helen Ngoc Bao Quach; Sinnakaruppan Mathavan; Karuna Sampath Despite extensive study, the earliest steps of vertebrate axis formation are only beginning to be elucidated. We previously showed that asymmetric localization of maternal transcripts...

... understanding of metazoan body plan evolution. * Author for correspondence ( [email protected] ) Competing interests statement The authors declare no competing financial interests. © 2012. 2012 Axis formation Evolution Gene regulation Segmentation Spiders The common...

... statement The authors declare no competing financial interests. 26 6 2011 © 2011. Ezh2 Hox Polycomb Axis formation Limb bud Plasticity Mouse Pattern formation in many embryonic contexts follows the acquisition of regionally distinct positional identities...

...Megan J. Wilson; Peter K. Dearden Axis formation is a key step in development, but studies indicate that genes involved in insect axis formation are relatively fast evolving. Orthodenticle genes have conserved roles, often with hunchback , in maternal anterior patterning in several insect species...

...David J. Duffy; Günter Plickert; Timo Kuenzel; Wido Tilmann; Uri Frank We studied the role of Wnt signaling in axis formation during metamorphosis and regeneration in the cnidarian Hydractinia . Activation of Wnt downstream events during metamorphosis resulted in a complete oralization...

... determination, demonstrating that Baz is essential for axis formation. The dynamics of Baz, Par-6 and Par-1 localisation in the oocyte indicate that the axis is not polarised by a cortical contraction as in C. elegans , and instead suggest that repolarisation of the oocyte is triggered by posterior inactivation...

... is regulated by Notch signaling and by Hh signaling itself. * Authors for correspondence ( [email protected] ; [email protected] ) Competing interests statement 3 2 2010 © 2010. Axis formation Cell migration Patched Hedgehog Smoothened Dpp RNAi Achaearanea...

... overexpression mimicked an organizer transplant. * Author for correspondence (e-mail: [email protected] ) 10 3 2009 © 2009. 2009 Goosecoid Chordin Noggin Follistatin-like Axis formation DV patterning Zebrafish Organizer Formation of the vertebrate...

... developmental abnormalities in Eomes/Nodal double heterozygotes, and demonstrate that these phenotypes reflect Eomes and Nodal interactions in different tissue sites. Collectively, our experiments establish that Eomes is a key regulator of anteroposterior axis formation, EMT and definitive endoderm...

... has a mixable condition that allows cells to intermingle with each other; and (5) regional heterogeneity along the PD axis exists even in the distal region. Molecular mechanisms for each process of the PD axis formation remain to be elucidated. We are grateful to Dr Cheryll Tickle for critical...

... wild-type levels ( Fig. 1F ). Expression of the mesodermal marker Xbra was also reduced in LRP6-depleted embryos ( Fig. 1E ). Although embryos and molecular markers were not completely rescued to the wild-type state, Wnt target gene expression and dorsal-axis formation were consistently recovered...

..., T., Murakami, R. et al. ( 2006 ). An unconventional myosin in Drosophila reverses the default handedness in visceral organs. Nature 440 , 798 -802. Hyatt, B. A. and Yost, H. J. ( 1998 ). The left-right coordinator: the role of Vg1 in organizing left-right axis formation. Cell 93 , 37 -46...