...Jose Ignacio Pueyo; Juan Pablo Couso Proximodistal patterning in Drosophila requires division of the developing leg into increasingly smaller, discrete domains of gene function. The LIM-HOM transcription factors apterous ( ap ) and Lim1 (also known as dlim1 ), and the homeobox genes Bar...

... for the development of the Drosophila wing, as well as vertebrate limbs. Here, we show that a 794 bp cis-regulatory element located in the 3′ region of the Ser gene can recapitulate the dynamic patterns of endogenous Ser expression during wing development. Using this enhancer element,we demonstrate that Apterous (Ap...

... , Ssdp is expressed in the developing nervous system and imaginal tissues, and it is capable of modifying the in vivo activity of complexes comprised of Chip and the LIM-homeodomain protein Apterous. Null mutations of the ssdp gene are cell-lethal in clones of cells within the developing wing disc...

... of the Drosophila Epidermal Growth Factor Receptor (EGFR). We show that EGFR signaling is necessary and sufficient to activate apterous ( ap ) expression, thereby segregating the wing disc into D ( ap -ON) and V ( ap -OFF) compartments. Similarly, we demonstrate that EGFR signaling directs the expression...

...Ulrich Weihe; Marco Milán; Stephen M. Cohen Apterous is a LIM-homeodomain protein that confers dorsal compartment identity in Drosophila wing development. Apterous activity requires formation of a complex with a co-factor, Chip/dLDB. Apterous activity is regulated during wing development by dLMO...

...Marco Milán; Ulrich Weihe; Stanley Tiong; Welcome Bender; Stephen M. Cohen Drosophila limbs develop from imaginal discs that are subdivided into compartments. Dorsal-ventral subdivision of the wing imaginal disc depends on apterous activity in dorsal cells. Apterous protein is expressed in dorsal...

...Maria Capovilla; Zakaria Kambris; Juan Botas ABSTRACT Hox genes control segment identity in the mesoderm as well as in other tissues. Most evidence indicates that Hox genes act cell-autonomously in muscle development, although this remains a controversial issue. We show that apterous expression...

.... The selector gene apterous ( ap ) is expressed in dorsal cells of the wing disc and is essential for D/V compartmentalization, wing margin formation, wing outgrowth and dorsal-specific wing structures. To better understand the mechanisms of Ap function and compartment formation, we have rescued aspects...

... , a member of the Lhx family of genes whose proteins contain two Lim domains and a homeodomain. We show that the Lhx gene apterous (ap) is also required for PD leg development, and we study the functional interactions between ap, dlim1 and other PD genes during leg development. Our results show...

...Arjuman Ghazi; Sumita Anant; K. VijayRaghavan ABSTRACT Two physiologically distinct types of muscles, the direct and indirect flight muscles, develop from myoblasts associated with the Drosophila wing disc. We show that the direct flight muscles are specified by the expression of Apterous, a Lim...

...Ronald J. Benveniste; Stefan Thor; John B. Thomas; Paul H. Taghert ABSTRACT We describe the direct and cell-specific regulation of the Drosophila FMRFa neuropeptide gene by Apterous, a LIM homeodomain transcription factor. dFMRFa and Apterous are expressed in partially overlapping subsets...

...Concepción Rodriguez-Esteban; John W. R. Schwabe; Jennifer De La Peña; Diego E. Rincon-Limas; Jorge Magallón; Juan Botas; Juan Carlos Izpisúa Belmonte ABSTRACT apterous specifies dorsal cell fate and directs outgrowth of the wing during Drosophila wing development. Here we show that, in vertebrates...

...Scott E. Lundgren; Christopher A. Callahan; Stefan Thor; John B. Thomas ABSTRACT The Drosophila apterous gene encodes a LIM homeo-domain protein expressed embryonically in a small subset of differentiating neurons. To establish the identity of these neurons and to study the role of apterous...

... position to act as barrier cells. (2) This cut -expressing region is split into dorsal and ventral regions by the expression of the dorsal-specific gene apterous . (3) The D/V lineage restriction defined by marked dorsal and ventral clones lies in the middle of the cut -expressing region and is exactly...

... to be the earliest-acting member of the hierarchy and crucial fordistinguishing the notum/wing subfields, and for the compartmentalization of the dorsal and ventral wing surfaces. The wingless product is required to restrict the expression of the apterous gene to dorsal cells and to promote the expression...