... ablation of Fgf8 gene function in the pharyngeal arch ectoderm and endoderm. Remarkably, ablating FGF8 protein in the pharyngeal arch ectoderm causes failure of formation of the fourth pharyngeal arch artery that results in aortic arch and subclavian artery anomalies in 95% of mutants; these defects...

... Branchial arch Aortic arch Rhombomere Plasticity Facial skeleton Hyoid bone Neural derivative Conotroncus Heart Glandular derivative Pharynx Quail Chick. The neural crest is a highly pluripotent structure that plays a critical role in the construction of the vertebrate head. In addition...

..., and exhibited interrupted aortic arch and skeletal defects in the neurocranium and the vertebral column. Interruption of the aortic arch seen in the mutant mice was the same as in human congenital anomalies. These results suggest that MFH-1 has indispensable roles during the extensive remodeling of the aortic...