...; however, germ line transmission of functional targeted knock-ins of protein tags or of SNP exchanges have not been reported. Here we show by phenotypic rescue that the CRISPR/Cas system can be used to target and repair a premature stop codon at the albino ( alb ) locus in zebrafish with high efficiency...

...Riva C. Marcus; Li-Chong Wang; Carol A. Mason ABSTRACT The visual pathway in albino animals is abnormal in that there is a smaller number of ipsilaterally projecting retinal ganglion cells. There are two possible sites of gene action that could result in such a defect. The first site is the retina...

...Satoshi Tanaka; Hiroaki Yamamoto; Sakae Takeuchi; Takuji Takeuchi We introduced a mouse tyrosinase minigene, mg-Tyrs-J , in which the authentic genomic 5′ non-coding flanking sequence was fused to a mouse tyrosinase cDNA, into fertilized eggs of albino mice. Of the 25 animals that developed from...

...R. W. Jeffery; Glen Jeffery; B. M. Cattanach ABSTRACT Female mice showing albino mosaicism due to an X-autosome translocation [Is(In7;X)Ct] have been studied in order to investigate the relationship between the distribution of melanin and the formation, early in development, of the abnormally small...

...M. S. Deol; Gillian M. Truslove; Anne McLaren ABSTRACT Cattanach’s insertion (Is(In7;X)lCt or X Ct ) includes the normal allele at the albino locus (c + ), which is subject to inactivation of the X chromosome carrying it, so that X Ct X; cc mice have albino and pigmented patches. The X-autosome...