...Andrea L. Sposato; Hailey L. Hollins; Darren R. Llewellyn; Jenna M. Weber; Madison N. Schrock; Jeffrey A. Farrell; James A. Gagnon ABSTRACT Vertebrate spermatogonial stem cells maintain sperm production over the lifetime of an animal, but fertility declines with age. Although morphological studies...

... gene, a powerful regulator of aging. The homologous mutation in the human insulin receptor causes Donohue syndrome, establishing these mutant worms as an invertebrate model of this disease. Captopril functions in C. elegans by inhibiting ACN-1, the worm homolog of ACE. Reducing the activity of acn-1...

... is matched to the anatomical origin of the PSPC, demonstrating a role for the embryonic Hox code in adult stem cells. Finally, we demonstrate that Hoxa10 overexpression partially restores the age-related decline in fracture repair. Together, our data highlight the importance of Hox genes as key regulators...

...Juan I. Bravo; Séverine Nozownik; Prakroothi S. Danthi; Bérénice A. Benayoun ABSTRACT Our understanding of the molecular regulation of aging and age-related diseases is still in its infancy, requiring in-depth characterization of the molecular landscape shaping these complex phenotypes. Emerging...

... with age. Here, we use time-lapse imaging and single cell RNA-seq to measure activation trajectories and rates in young and aged MuSCs. We find that the activation trajectory is conserved in aged cells, and we develop effective machine-learning classifiers for cell age. Using cell-behavior analysis and RNA...

...Muriel Rhinn; Birgit Ritschka; William M. Keyes ABSTRACT Cellular senescence is a state comprising an essentially irreversible proliferative arrest combined with phenotypic changes and pronounced secretory activity. Although senescence has long been linked with aging, recent studies have uncovered...

...Yuka Nakatani; Hiroshi Kiyonari; Toru Kondo ABSTRACT The self-renewal activity of neural stem cells (NSCs) has been suggested to decrease with aging, resulting in age-dependent declines in brain function, such as presbyopia and memory loss. The molecular mechanisms underlying decreases in NSC...

... with the induction of sex hormones (either surgically or pharmacologically) at 2 weeks of age resulted in prolonged cycling and delayed entry into quiescence. Notch signaling has proven to be crucial for maintaining SC quiescence throughout adulthood. Postnatal SC-specific disruption of the Notch effector RBP-Jκ...

...Hongbo Zhang; Keir J. Menzies; Johan Auwerx ABSTRACT The importance of mitochondria in energy metabolism, signal transduction and aging in post-mitotic tissues has been well established. Recently, the crucial role of mitochondrial-linked signaling in stem cell function has come to light...

... declines with age. Increasing Wnt activity upon loss of dickkopf 1 can counteract both the decline of newborn neurons and the age-related cognitive decline. However, the precise cellular changes underlying the age-related decline or its rescue are fundamentally not understood. The present study combines...

...Helen Marie Tauc; Alpaslan Tasdogan; Patrick Meyer; Petra Pandur Adult stem cells uphold a delicate balance between quiescent and active states, a deregulation of which can lead to age-associated diseases such as cancer. In Drosophila , intestinal stem cell (ISC) proliferation is tightly regulated...

...Anna Bigas; Claudia Waskow In June 2016, around 200 scientists from all over the world gathered at EMBL headquarters in Heidelberg, Germany to discuss the recent advances in hematopoietic stem cells from three different angles: developmental, adulthood and aging. The meeting, aptly named...

... stem cell (iPSC) differentiation protocols yield cells that typically show the behavior of fetal stage cells. Acknowledging aging as a contributing factor in late-onset neurodegenerative disorders represents an important step on the road towards faithfully recreating these diseases in vitro . Here, we...

... in degenerative conditions such as aging, can impair muscle regeneration. Here, we review recent discoveries of the intrinsic and extrinsic factors that regulate satellite cell behaviour in regenerating and degenerating muscles. * Author for correspondence ( [email protected] ) Competing interests...

... Growth Aging C. elegans Epigenetics dpy-21 The target of rapamycin (TOR) kinase regulates metabolism, development, growth and lifespan by its action in two distinct complexes: TOR complex 1 and TOR complex 2 ( Bhaskar and Hay, 2007 ; Alessi et al., 2009 ; Jones et al., 2009...

...Xinxin Huang; Hui Zhang; Hong Zhang Like other biological processes, aging is regulated by genetic pathways. However, it remains largely unknown whether aging is determined by an innate programmed timing mechanism and, if so, how this timer is linked to the mechanisms that control developmental...

... and life span. * Author for correspondence (e-mail: [email protected] ) 6 5 2004 ©2004. 2004 TOR Raptor daf-15 Dauer formation Aging Insulin In multicellular organisms, the control of growth depends on the integration of genetic and environmental cues( Conlon...

... reduction in C. elegans life span was observed, with accompanying signs of premature aging, such as earlier accumulation of lipofuscin and tissue deterioration in the head. In addition,various developmental defects, including small, dumpy, ruptured, transparent body, growth arrest and bag of worms, were...

[email protected] ) 12 1 2004 © 2004. 2004 Dauer Hormone Aging C. elegans Cholesterol Fundamental insights into how genes and environment influence metazoan metabolism, development and aging have emerged from a genetic dissection of C. elegans diapause. Despite its simplicity, C...

... a previously unrecognized role for these cells in neuroendocrine control of larval development, reproduction and life span. *Author for correspondence (e-mail: [email protected] ) 11 10 2001 © 2002. 2002 Cytochrome P450 Dauer formation Aging daf-9 daf-12 TGF-β Insulin...