... follicles (clones) composed of Sl/Sl epidermal cells (Fig. 3A , B). The present results indicate that aggregation chimaeras have a unique usefulness for clarifying the actions of genes at the SI locus. Information obtained from experiments employing tissue recombination procedures is somewhat...

... cells is not attributable to an intrinsic defect in their precursor cells but to a defect in the tissue environment that is necessary for migration, proliferation and/or differentiation. We investigated the mechanism of germ cell deficiency in male Sl/Sl d mice by producing aggregation chimaeras from Sl...

... and fertilized ↔ fertilized aggregation chimaera Table 1 summarizes the postimplantation development of the experimentally aggregated embryos. In the control Groups 3 and 4, normally fertilized BCF2 embryos were used in the place of parthenogenetic (BCF1) counterpart of Groups 1 and 2. Overall...

... of limited nutrient supply is discussed. 24 01 1986 Copyright © 1986 by Company of Biologists 1986 size regulation mouse embryo aggregation chimaera growth Chimaeras produced by the aggregation of early embryos have been widely used in experimental investigations of mammalian...