...Erica D. Watson; Colleen Geary-Joo; Martha Hughes; James C. Cross Defects in protein-folding and -degradation machinery have been identified as a major cause of intracellular protein aggregation and of aggregation-associated diseases. In general, it remains unclear how these aggregates are harmful...

...M. L. Springer; B. Patterson; J. A. Spudich ABSTRACT Dictyostelium cells that lack a functional myosin II heavy chain are motile and are capable of aggregation, but fail to undergo further multicellular development. We have used a Dictyostelium mutant expressing a cold-sensitive myosin heavy chain...

...Usha K. Srinivas; Ellen J. Henderson ABSTRACT A temperature-sensitive mutant of Dictyostelium discoideum has been isolated based on its lack of chemotaxis toward cyclic AMP at the restrictive temperature, 27°C. The mutant develops normally at the permissive temperature, 22°C, but fails to aggregate...

...John J. Tyson; J. D. Murray ABSTRACT During the aggregation phase of their life cycle, Dictyostelium discoideum amoebae communicate with each other by traveling waves of cyclic AMP. These waves are generated by an interplay between random diffusion of cyclic AMP in the extracellular milieu...

...Lois H. Browne; Homa Sadeghi; Daphne Blumberg; Keith L. Williams; Claudette Klein ABSTRACT 117 antigen is a glycoprotein expressed on the surface of D. discoideum cells at aggregation. It then disappears and is later re-expressed on the surface of a subpopulation of cells at culmination...