.... Avascular areas harbored cells with more pyknotic nuclei and elevated apoptosis, and vascularized areas had dilated capillaries that appeared to be intact and patent, although they had disorganized adherens junctions and were less mature along the LSEC lineage. Hemorrhage was found within and near avascular...

... from the adherens junctions to the nucleus to stimulate Tcf-dependent transcription in a Wnt-independent manner. This new β-catenin activity regulates genes implicated in several aspects of contralateral axon growth, including axon guidance and adhesion. Using live imaging of ex-vivo chick neural tube...

... adhesions and integrin adhesions ( Bays and DeMali, 2017 ). Vinculin conformational activation at cadherin-containing adherens junctions requires tension and phosphorylation at tyrosine residue Y822, which is regulated by the nonreceptor tyrosine kinase c-Abl ( Bays et al., 2014 ; Bertocchi et al., 2017...

... in Xenopus . Lmo7 Actomyosin contractility Non-muscle myosin II Adherens junctions Morphogenesis Xenopus ectoderm National Institutes of Health R35GM122492 Apical constriction, or reduction in size of the apical domain, underlies a variety of morphogenetic processes during...

... be influenced by the size, composition or dynamics of contacts between membranes. The initiation of Notch signalling in the Drosophila embryo occurs during cellularization, when lateral cell membranes and adherens junctions are first being deposited, allowing us to investigate the importance of membrane...

... to PCP defects. Tmsb4x depletion did not preclude epidermal cell adhesion in vivo or in vitro ; however, it resulted in abnormal structural organization and stability of adherens junction (AJ) due to defects in filamentous (F)-actin and G-actin distribution. In cultured keratinocytes, TMSB4X depletion...

... it occurs via rapid remodeling of adherens junctions or focal adhesion assembly, or both, remains poorly understood. Furthermore, how endothelial cell adhesion is controlled in particular tissues and under different conditions remains unexplored. Here, we have identified an unexpected role...

... (WC). To study this, we examined adherens junctions during WC in Drosophila larvae. β-Catenin is reduced at the lateral cell-cell junctions of wound-edge epidermal cells in the early healing stages. Destruction complex components, including Ck1α, GSK3β and β-TrCP, suppress β-catenin levels...

... required for regulation of adherens junction (AJ) stability and dynamics. However, much less is known about how such phosphorylation of E-Cadherin regulates AJ formation and dynamics in vivo . In this report, we generated an extensive array of Drosophila E-Cadherin (DE-Cad) endogenous knock-in alleles...

... retinal organisation and rescues most vav mutant phenotypes. Second, using live imaging in the pupal retina, we observe that vav mutant cells do not form stable adherens junctions, causing various defects, such as recruitment of extra primary pigment cells. In agreement with this role in junction dynamics...

... pupal lattice, in which hexagonal ommatidial units pack tightly. This process involves the fine regulation of adherens junctions (AJs) and of adhesive E-Cadherin (E-Cad) complexes. Localized accumulation of Bazooka (Baz), the Drosophila PAR3 homolog, has emerged as a critical step to specify where new E...

...Pierre-Marie Le Droguen; Sandra Claret; Antoine Guichet; Véronique Brodu Epithelial remodelling is an essential mechanism for organogenesis, during which cells change shape and position while maintaining contact with each other. Adherens junctions (AJs) mediate stable intercellular cohesion...

... Tight junctions Adherens junctions Interkinetic nuclear migration Midbrain Chick During neurulation, a flat neural plate rolls up to form a closed neural tube. This process involves diverse cell behaviors at specialized regions of the neural plate called hinge points (HPs...

... into an activity that is likely to participate, along with canonical Wnt signaling, in the stimulation of neural crest emigration. * Author for correspondence (e-mail: [email protected] ) 9 11 2006 © 2007. 2007 Adherens junctions β-catenin Cell cycle Epithelial...

.... † Authors for correspondence (e-mail: [email protected] ; [email protected] ) * These authors contributed equally to this work 7 4 2006 © 2006. 2006 Mutation cluster region Familial adenomatous polyposis Adherens junctions β-Catenin Many genes mutated...

... mechanisms underlie the establishment of pioneer and later myotomal waves. * Author for correspondence (e-mail: [email protected] ) 18 1 2006 © 2006. 2006 Adherens junctions Asymmetric cell division Avian embryo Cell adhesion Dermis Dermomyotome Desmin...

... localises at adherens junctions of the developing photoreceptor cells. A structure-function analysis of the Mbt protein in vitro and in vivo revealed that the Mbt kinase domain and the GTPase binding domain, which specifically interacts with GTP-loaded Cdc42, are important for Mbt function. Besides...

... of cell biological and anatomical approaches, we have determined a complete morphogenetic pathway of cellular events that lead to the formation of the vulva. These events include reproducible cell divisions, migrations, remodeling of adherens junctions, cell fusions and muscle attachments. In the course...

... to the membrane at sites of cell adhesion, mediated by adherens junctions, initially spot and later belt-like, zonular structures, which encircle the apical side of the cell. Loss-offunction mutations in the Drosophila genes crumbs and stardust lead to the loss of cell polarity in most ectodermally derived...

...Ekaterina J. Goncharova; Zvi Kam; Benjamin Geiger ABSTRACT The distribution of adherens junction (AJ) components was investigated in cultured heart myocytes. These cells, derived from either newborn rats or chick embryos, develop elaborate arrays of myofibrils which become extensive and laterally...