... Midline mutant Adaxial cells dzip1 PEST sequence Zebrafish During animal development, cell fates are specified in response to gradients of signaling molecules within the embryo. Members of the Hedgehog(Hh) family of intercellular signaling molecules control a variety of developmental...

... edge of the hypoblast during involution, all Has2-dependent cells migrate as small groups of cells or individual cells. In particular the Has2-dependent migration of adaxial cells through the somites( Devoto et al., 1996 ; Stickney et al., 2000 ) is very reminiscent of tissue invasion by metastatic...

...-mail: [email protected] ) 14 11 2002 © 2003. 2003 Forebrain patterning Hedgehog signaling Adaxial cells floor plate cyclopamine Morpholino Members of the Hedgehog (Hh) family of intercellular signaling molecules control a variety of developmental processes, ranging from...

... shows that diwanka gene activity is required in a small set of myotomal cells, called adaxial cells. We identified a subset of the adaxial cells to be sufficient to rescue the diwanka motor axon defect. Moreover, we show that this subset of adaxial cells delineates the common axonal path prior...

... somites is abnormal. In the second group of mutants, formation of the horizontal myoseptum, which separates the dorsal and ventral part of the myotome, is reduced. Six genes have been defined in this group ( you -type genes). you-too mutants show the most severe phenotype; in these the adaxial cells...