... molecule determining ventral neuronal cell fates. Here we provide evidence that canonical Wnt signaling is involved in the generation of different cell types in the ventral spinal cord. We show that Wnt signaling is active in the mouse ventral spinal cord at the time when ventral cell types are specified...

... Xmyf-5 ( Xtmyf-5 ) genomic DNA fragment that accurately recapitulates the expression of the endogenous gene. Deletion and mutational analysis has identified HBX2, an essential element, approximately 1.2 kb upstream from the start of transcription, which is necessary for both activation and repression...

... evidence, from in vivo studies, for the transcriptional-activating function of HTH. The HTH protein was forced to act as a transcriptional repressor by fusing it to the Engrailed (EN) repression domain, or as a transcriptional activator, by fusing it to the VP16 activation domain, without perturbing its...

...Rubén Darío Flores-Saaib; Songtao Jia; Albert J. Courey ABSTRACT In the Drosophila embryo, Dorsal, a maternally expressed Rel family transcription factor, regulates dorsoventral pattern formation by activating and repressing zygotically active fate-determining genes. Dorsal is distributed...

... and facilitates its conversion into an activator. Recently, it has been suggested that Hh promotes Ci nuclear import in tissue culture cells. We have studied the mechanism of Ci nuclear import in vivo and the relationship between nuclear import, stabilization and activation. We found that Ci rapidly translocates...

...Petr Kalab; Jacek Z. Kubiak; Marie-Hélène Verlhac; William H. Colledge; Bernard Maro ABSTRACT Mitogen-activated protein kinases (MAPK) become activated during the meiotic maturation of oocytes from many species; however, their molecular targets remain unknown. This led us to characterize...

...Tomohiro Kono; John Carroll; Karl Swann; David G. Whittingham ABSTRACT During mammalian fertilization, the sperm triggers a series of intracellular Ca 2+ oscillations which initiate oocyte activation and the formation of pronuclei. Oocyte activation can be induced artificially by a variety...

... the cell division inhibitors seem to reduce all gene transcription, they have no preferential effect on the response to induction, and therefore that this process does not require cytoplasmic or nuclear division. Copyright © 1986 by Company of Biologists 1986 muscle activation induction cell...