... Drosophila melanogaste Achaete-scute Complex Insulator Su(Hw) Mod(mdg4) Enhancer blocking Enhancer-mediated activation is a fundamental mechanism of gene regulation in eukaryotes. Enhancers can act over large distances to activate transcription, independent of their orientation and position...

.... However, despite extensive analysis, the precise pathways linking the proneural with Notch and Enhancer of split gene functions remain obscure. For example, it has been suggested that achaete-scute complex proteins directly activate Enhancer of split genes leaving the action of Notch in the pathway...

... and requires proneural and neurogenic genes. In neurogenic mutants the principle midgut epithelial cells are missing and the other two cell types develop in great excess. Consequently, the midgut epithelium does not form. In achaete-scute complex and daughterless mutants the interstitial cell precursors do...

... organs. Second, in mutants that induce the development of ectopic sensory organs glial cells develop at new positions. These findings prompted a genetic analysis to establish whether glial and sensory organ differentiation depend on the same genes. Loss of function mutations of the achaete-scute complex...

...-of-scute of the achaete-scute complex. These genes encode basic helix-loop-helix proteins, which are nuclear transcription factors, as does the asense gene of the achaete-scute complex. Our studies suggest that asense is a neural precursor gene, rather than a proneural gene. Unlike the proneural achaete...

... proteins achaete-scute complex sex determination dosage compensation Sex-lethal sisterless genes Drosophila Table 4. Ectopic AS-C expression rescues sis-b female-lethality hb- AS-C rescue is not due to cross-activation of the sis-b 3-1 gene since early T4...

... Drosophila embryo achaete-scute complex The structural and biochemical complexity of the nervous system is somehow coded for by the genome. How this is done, and how much genetic information is required to generate this complexity, is not known. Estimates of the number of unique mRNA sequences...