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Keywords: Zygotic genome activation
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Journal Articles
Journal: Development
Development (2022) 149 (5): dev200044.
Published: 28 February 2022
... oocytes include Zscan4d , a two-cell specific gene involved in zygote genome activation. Overexpression of Zscan4 in the oocyte partially recapitulates the phenotypes of Hira mutants and Zscan4 knockdown in Cabin1 mutant oocytes partially restored their developmental potential, illustrating that temporal...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2021) 148 (24): dev200178.
Published: 21 December 2021
...Zhiyuan Chen; Zhenfei Xie; Yi Zhang ABSTRACT How maternal factors in oocytes initiate zygotic genome activation (ZGA) remains elusive in mammals, partly due to the challenge of de novo identification of key factors using scarce materials. Two-cell (2C)-like cells have been widely used...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2021) 148 (24): dev200191.
Published: 21 December 2021
...Oana Kubinyecz; Fatima Santos; Deborah Drage; Wolf Reik; Melanie A. Eckersley-Maslin ABSTRACT Zygotic genome activation (ZGA) represents the initiation of transcription following fertilisation. Despite its importance, we know little of the molecular events that initiate mammalian ZGA in vivo...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (2): dev177725.
Published: 23 January 2020
... ). Loss of DUX causes minor defects in zygotic genome activation and is compatible with mouse development . Nat. Genet   51   10.1038/s41588-019-0418-7 De Iaco , A. , Planet , E. , Coluccio , A. , Verp , S. , Duc , J. and Trono , D. ( 2017 ). DUX-family transcription...
Journal Articles
Journal: Development
Development (2019) 146 (19): dev177402.
Published: 4 October 2019
... histones. Previous work suggests that the pool size of maternally provided histones can alter the timing of zygotic genome activation (ZGA) in frogs and fish. Here, we examine the effects of under- and overexpression of maternal histones in Drosophila embryogenesis. Decreasing histone concentration...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (19): dev179127.
Published: 30 September 2019
... development remain difficult to capture. We applied a Fab-based live endogenous modification labeling technique to monitor the changes in histone modification levels during zygotic genome activation (ZGA) in living zebrafish embryos. Among various histone modifications, H3 Lys27 acetylation (H3K27ac...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (1): dev147793.
Published: 9 January 2018
... gene expression in embryonic cells. In an alternative scenario, Nanog has been proposed to directly regulate transcription in embryonic cells during zygotic genome activation. To clarify the roles of Nanog, we performed a detailed analysis of zebrafish nanog mutants. Whereas zygotic nanog mutants...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (1): dev156521.
Published: 3 January 2018
...Michael Meier; Jenny Grant; Amy Dowdle; Amarni Thomas; Jennifer Gerton; Philippe Collas; Justin M. O'Sullivan; Julia A. Horsfield At zygotic genome activation (ZGA), changes in chromatin structure are associated with new transcription immediately following the maternal-to-zygotic transition (MZT...
Includes: Supplementary data