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Keywords: Zebrafish
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Journal Articles
Journal: Development
Development (2021) 148 (9): dev198101.
Published: 29 April 2021
... Wnt inhibitor by interfering with the formation of β-catenin/Tcf transcription activation complex. As Wnt stimulation increases, accumulated β-catenin displaces EIF4A3 from a transcriptional complex with Tcf/Lef, allowing the active complex to facilitate the expression of target genes. In zebrafish...
Includes: Supplementary data
Journal Articles
Journal: Development
Development dev.199384.
Published: 26 April 2021
... replacement growth. Fish fins exemplify both phenomena through their tremendous diversity of form and remarkably robust regeneration. The classic zebrafish mutant longfin t2 develops and regenerates dramatically elongated fins and underlying ray skeleton. We show longfin t2 chromosome 2 overexpresses the...
Journal Articles
Journal: Development
Development dev.193508.
Published: 15 April 2021
... observations, making them powerful tools for replication and future simulations. * Authors for correspondence: ugeorge@sdsu.edu ; ksant@sdsu.edu 2 6 2020 29 3 2021 © 2021. Published by The Company of Biologists Ltd 2021 Embryonic development Zebrafish Yolk absorption...
Journal Articles
Journal: Development
Development (2021) 148 (7): dev197483.
Published: 15 April 2021
... frontonasal neural crest cell subpopulations. This study furthers our understanding of how genes controlling developmental timing shape craniofacial skeletal elements. 30 9 2020 12 3 2021 © 2021. Published by The Company of Biologists Ltd 2021 Summary: Zebrafish single-cell...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (7): dev194258.
Published: 15 April 2021
... npc2 m/m zebrafish showed significant unesterified cholesterol accumulation at larval stages, a reduction in body size, and motor and balance defects in adulthood. However, the phenotype at embryonic stages was milder than expected, suggesting a possible role of maternal Npc2 in embryonic development...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (7): dev192344.
Published: 06 April 2021
... tissues over many temporal and spatial scales: BMP gradients as short as 1-2 cell diameters maintain the stem cell niche of the Drosophila germarium over a 24-h cycle, and BMP gradients of several hundred microns establish dorsal-ventral tissue specification in Drosophila , zebrafish and Xenopus embryos...
Journal Articles
Journal: Development
Development (2021) 148 (4): dev192443.
Published: 17 February 2021
... itself phosphorylated by PKA, but the functional significance of PKA phosphorylation of Gpr161 in the context of Hh signalling remains unknown. Here, we show that loss of Gpr161 in zebrafish leads to constitutive activation of medium and low, but not maximal, levels of Hh target gene expression...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (2): dev193409.
Published: 25 January 2021
... factor NKX3.2 underlie spondylo-megaepiphyseal-metaphyseal dysplasia (SMMD), which is characterized by skeletal defects including scoliosis, large epiphyses, wide growth plates and supernumerary distal limb joints. Whereas nkx3.2 knockdown zebrafish and mouse Nkx3.2 mutants display embryonic lethal jaw...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (2): dev193060.
Published: 20 January 2021
... biogenesis signatures. Interestingly, no nuclear Piwi protein could be detected at any time point, indicating that the zebrafish piRNA pathway is fully cytoplasmic. Our data show that the post-migratory stage of zebrafish PGCs holds many cues to both germ cell fate establishment and piRNA pathway activation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (2): dev193219.
Published: 18 January 2021
...Debanjan Mukherjee; Ganesh Wagh; Mayssa H. Mokalled; Zacharias Kontarakis; Amy L. Dickson; Amey Rayrikar; Stefan Günther; Kenneth D. Poss; Didier Y. R. Stainier; Chinmoy Patra ABSTRACT The ability of zebrafish to heal their heart after injury makes them an attractive model for investigating the...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (1): dev194241.
Published: 11 January 2021
... through life, in zebrafish these cells are transient, as they are fully replaced by an adult population originating from larval hematopoietic stem cell (HSC)-derived progenitors. Colony-stimulating factor 1 receptor (Csf1r) is a fundamental regulator of microglia ontogeny in vertebrates, including...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (24): dev191494.
Published: 23 December 2020
...Andrew C. Symonds; Clare E. Buckley; Charlotte A. Williams; Jonathan D. W. Clarke ABSTRACT Using the zebrafish neural tube as a model, we uncover the in vivo mechanisms allowing the generation of two opposing apical epithelial surfaces within the centre of an initially unpolarised, solid organ. We...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (24): dev194019.
Published: 23 December 2020
... dynamic transcriptional response relies on the activities of tissue regeneration enhancer elements (TREEs); however, the mechanisms underlying TREEs are poorly understood. We dissected a cardiac regeneration enhancer in zebrafish to elucidate the mechanisms governing spatiotemporal gene expression during...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (24): dev192971.
Published: 21 December 2020
... necessary for their function. Although our understanding of the mechanisms controlling morphogenesis and neurogenesis in these structures has grown, how these processes are coordinated remains largely unexplored. Neurogenesis in the zebrafish olfactory epithelium requires the bHLH proneural transcription...
Journal Articles
Journal: Development
Development (2020) 147 (24): dev193946.
Published: 16 December 2020
... sheaths, all of which are not efficiently restored. The scarcity of oligodendrocytes in the lesion site impairs re-myelination of spared fibres, which leaves axons denuded, impedes signal transduction and contributes to permanent functional deficits. In contrast to mammals, zebrafish can functionally...
Journal Articles
Journal: Development
Development (2020) 147 (23): dev191973.
Published: 14 December 2020
... lineage assignment in the developing zebrafish pronephros by repressing Tfap2a activity. During renal ontogeny, expression of these factors colocalized with tfap2a in distal tubule precursors. kctd15a/b loss primed nephron cells to adopt distal fates by driving slc12a1 , kcnj1a.1 and stc1 expression...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (22): dev190728.
Published: 30 November 2020
... activity. Here, we establish an inactive mR3-based non-engineered mR3/dsRNA system for RNA tracking in zebrafish embryos. In vitro binding experiments show that inactive Staphylococcus epidermidis mR3 (dSmR3) protein possesses the highest binding affinity with dsRNAs among mR3s from other related species...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2020) 147 (22): dev189811.
Published: 29 November 2020
...Zhiwei Zhang; Kun Wu; Zhiqin Ren; Wei Ge ABSTRACT Anti-Müllerian hormone (Amh) plays an important role in gonadal function. Amh deficiency causes severe gonadal dysgenesis and dysfunction in zebrafish, with gonadal hypertrophy in both sexes. However, its mechanism of action remains unknown...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (22): dev192500.
Published: 23 November 2020
... genetic programs that can interact with each other during embryogenesis. Here, we have taken advantage of the different span of embryonic development between two distantly related teleosts, zebrafish ( Danio rerio ) and medaka ( Oryzias latipes ) (3 and 9 days, respectively), to explore modularity...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (22): dev185116.
Published: 15 November 2020
... that loss of hif3 a in zebrafish reduced hypoxia tolerance. Further assays indicated that erythrocyte number was decreased because red blood cell maturation was impeded by hif3 a disruption. We found that gata1 expression was downregulated in hif3 a null zebrafish, as were several hematopoietic marker...
Includes: Supplementary data