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Keywords: Zebrafish
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Journal Articles
Journal Articles
Journal Articles
Journal: Development
Series: REVIEW COMMONS TRANSFER
Development (2024) 151 (4): dev202217.
Published: 21 February 2024
... architecture at high spatiotemporal resolution remains challenging. We developed LiverZap, a tuneable chemoptogenetic liver injury model in zebrafish. LiverZap employs the formation of a binary FAP-TAP photosensitiser followed by brief near-infrared illumination inducing hepatocyte-specific death...
Includes: Supplementary data
Journal Articles
Journal: Development
Series: REVIEW COMMONS TRANSFER
Development (2024) 151 (4): dev202316.
Published: 19 February 2024
... key roles in germ layer specification and morphogenesis, yet their interplay to coordinate embryo patterning with morphogenesis is still insufficiently understood. Here, we took a reductionist approach using zebrafish embryonic explants to study the coordination of Nodal and BMP signaling for embryo...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2024) 151 (4): dev202183.
Published: 13 February 2024
.... Previous studies in zebrafish have shown that sustained FGF signaling acts upstream of Nkx factors to maintain ventricular identity, but the rest of this maintenance pathway remains unclear. Here, we show that MEK1/2-ERK1/2 signaling acts downstream of FGF and upstream of Nkx factors to promote ventricular...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2024) 151 (3): dev201829.
Published: 5 February 2024
... to regulate neurogenesis and neural function, and to maintain the homeostasis of the CNS. Recent single cell transcriptomic profiling has revealed that the adult zebrafish CNS contains microglia, plasmacytoid dendritic cells (pDCs) and two conventional dendritic cells (cDCs), ccl35 + cDCs and cnn3a + cDCs...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2024) 151 (2): dev202251.
Published: 26 January 2024
... to distill cell and nuclear shape variation into discrete biologically meaningful parameters. We apply these methods to analyze shape in the neuromast cells of the zebrafish lateral line system, finding that shapes vary with cell location and identity. The distinction between hair cells and support cells...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2024) 151 (2): dev202315.
Published: 24 January 2024
... differentiation or self-renewal; however, this has been hampered by a lack of robust basal cell markers and analytical platforms that allow single-cell tracking. Here, we report that zebrafish integrin beta 4 is a useful marker for basal cell labelling, irrespective of the body region, stage and regenerative...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2024) 151 (2): dev201716.
Published: 12 January 2024
..., including expression of Ihh and Col10a1 . Because bone morphogenetic proteins (BMPs) can promote cartilage maturation, we hypothesized that cartilage PGs normally inhibit BMP signalling. Accordingly, BMP signalling was evaluated in chondrocytes of wild-type and PG mutant ( fam20b −/− ) zebrafish...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2024) 151 (1): dev202407.
Published: 4 January 2024
...Michael Morales; Anna P. Findley; Diana M. Mitchell ABSTRACT To clarify our understanding of glial phagocytosis in retinal development, we used real-time imaging of larval zebrafish to provide cell-type specific resolution of this process. We show that radial Müller glia frequently participate...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2023) 150 (24): dev202076.
Published: 11 December 2023
...Clayton J. Becker; Valentina Cigliola; Pierre Gillotay; Ashley Rich; Alessandro De Simone; Yanchao Han; Stefano Di Talia; Kenneth D. Poss ABSTRACT Identification of signaling events that contribute to innate spinal cord regeneration in zebrafish can uncover new targets for modulating injury...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2023) 150 (21): dev201824.
Published: 8 November 2023
... the cellular behaviours involved in the 3D organization of the SAG, we use high-resolution confocal imaging of single-cell, labelled zebrafish neuroblasts (NBs), photoconversion, photoablation, and genetic perturbations. We show that otic NBs delaminate out of the otic epithelium in an epithelial-mesenchymal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2023) 150 (21): dev202338.
Published: 8 November 2023
... find that H2A.Z resides at a subset of evolutionarily young repetitive elements, including DNA transposons, long interspersed nuclear elements and long terminal repeats, during early zebrafish development. Moreover, increases in H2A.Z occur when repetitive elements become transcriptionally active...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2023) 150 (21): dev201890.
Published: 24 October 2023
...-binding proteins (RBPs) to regulate RNA metabolism. Here, we report that the RBP protein Csde1-mediated translational control is essential for HSPC generation during zebrafish early development. Genetic mutants and morphants demonstrated that depletion of csde1 impaired HSPC production in zebrafish...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2023) 150 (18): dev201866.
Published: 25 September 2023
... are not fully understood. Here, we have used live imaging to investigate dynamic signals regulating the ontogeny of zebrafish scales. Scales are bony skin appendages that develop sequentially along the anterior-posterior and dorsal-ventral axes to cover the fish in a hexagonal array. We have found that scale...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2023) 150 (18): dev201707.
Published: 25 September 2023
...Alessio Paolini; Dinara Sharipova; Tim Lange; Salim Abdelilah-Seyfried ABSTRACT During zebrafish heart formation, cardiac progenitor cells converge at the embryonic midline where they form the cardiac cone. Subsequently, this structure transforms into a heart tube. Little is known about...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2023) 150 (18): dev201319.
Published: 14 September 2023
...Sami A. Leino; Sean C. J. Constable; Andrea Streit; David G. Wilkinson ABSTRACT Developing tissues are sequentially patterned by extracellular signals that are turned on and off at specific times. In the zebrafish hindbrain, fibroblast growth factor (Fgf) signalling has different roles at different...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2023) 150 (16): dev201141.
Published: 18 August 2023
...-expressed in entheseal tenocytes, scleraxis (Scx) and Sox9, directly control production of enthesis ECM components. Formation of embryonic craniofacial entheses in zebrafish coincides with onset of jaw movements, possibly in response to the force of muscle contraction. We show dynamic changes in scxa...
Includes: Supplementary data