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Keywords: Zebrafish
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Journal Articles
Journal: Development
Development (2022) 149 (9): dev177998.
Published: 12 May 2022
... and execute behaviors. Animal behavior can, therefore, serve as a functional readout of nervous system development. Benefitting from an expansive and growing set of molecular and imaging tools paired with an ever-growing number of assays of diverse behaviors, the zebrafish system has emerged as an outstanding...
Journal Articles
Journal: Development
Development (2022) 149 (9): dev190421.
Published: 9 May 2022
... differentiation. Here, we describe the Gt(SAGFF27C); Tg(4xUAS:egfp) line as a marker of endocardial development in zebrafish. Transcriptomic comparison between endocardium and pan-endothelium confirms molecular distinction between these populations and time-course analysis suggests differentiation as early...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (9): dev200136.
Published: 3 May 2022
..., in the development and function of the zebrafish node. We show jnk1 and jnk2 specify length of nodal cilia, generate flow in the node and restrict southpaw to the left lateral plate mesoderm. Moreover, loss of asymmetric southpaw expression does not result in disturbances to asymmetric organ placement, supporting...
Includes: Supplementary data
Journal Articles
Journal: Development
Development dev.200390.
Published: 3 May 2022
... in zebrafish, and determined that DNA methyltransferase 1 (Dnmt1) is essential for HSPC generation via repression of Notch signaling. Depletion of dnmt1 resulted in decreased DNA methylation levels and impaired HSPC production. Mechanistically, we found that loss of dnmt1 induced hypomethylation of Notch genes...
Journal Articles
Journal: Development
Development (2022) 149 (8): dev199803.
Published: 29 April 2022
...Karina Geurtzen; Alejandra Cristina López-Delgado; Ankita Duseja; Anastasia Kurzyukova; Franziska Knopf ABSTRACT In zebrafish, transgenic labeling approaches, robust regenerative responses and excellent in vivo imaging conditions enable precise characterization of immune cell behavior in response...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (7): dev200339.
Published: 7 April 2022
...Yukino Wada; Hikaru Tsukatani; Chihiro Kuroda; Yurika Miyazaki; Miku Otoshi; Isao Kobayashi ABSTRACT During development, the somites play a key role in the specification of hematopoietic stem cells (HSCs). In zebrafish, the somitic Notch ligands Delta-c (Dlc) and Dld, both of which are regulated...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (7): dev199640.
Published: 5 April 2022
... development and tissue regeneration, we studied zebrafish caudal fin arteries. Mural cells colonizing arteries proximal to the body wrapped around them, whereas those in more distal regions extended protrusions along the proximo-distal vascular axis. Both cell populations expressed platelet-derived growth...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (6): dev200375.
Published: 25 March 2022
..., the heart grows by addition of progenitor cells to the poles of the primordial heart tube. In the zebrafish, Wilms tumor 1 transcription factor a ( wt1a ) and b ( wt1b ) genes are expressed in the pericardium, at the venous pole of the heart. From this pericardial layer, the proepicardium emerges...
Includes: Supplementary data
Journal Articles
Journal: Development
Series: REVIEW COMMONS TRANSFER
Development (2022) 149 (6): dev199858.
Published: 24 March 2022
..., stabilisation and maintenance of blood vessel connections remain poorly defined. Here, we identify blood flow and the large extracellular protein Svep1 as co-modulators of vessel anastomosis during developmental angiogenesis in zebrafish embryos. Both loss of Svep1 and blood flow reduction contribute...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (6): dev199363.
Published: 17 March 2022
... with Rab11 prevents the accumulation of apically derived endosomes to maintain cell-size, whereas that with Rab10 regulates vesicular transport from the trans-Golgi. These interactions are required for the fine-tuning of the epithelial cell morphology during zebrafish development. Furthermore...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (5): dev199995.
Published: 11 March 2022
... diseases is treated using bone-grafting techniques that suffer from numerous shortcomings and contraindications. Zebrafish naturally heal large injuries to mandibular bone, offering an opportunity to understand how to boost intrinsic healing potential. Using a novel her6:mCherry Notch reporter, we show...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (5): dev199676.
Published: 4 March 2022
...-resolution imaging to document the stepwise assembly of the zebrafish pectoral fin vasculature. We show that fin vascular network formation is a stereotyped, choreographed process that begins with the growth of an initial vascular loop around the pectoral fin. This loop connects to the dorsal aorta...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (4): dev199752.
Published: 25 February 2022
... ABSTRACT Endothelial cells emerge from the atrioventricular canal to form coronary blood vessels in juvenile zebrafish hearts. We find that pdgfrb is first expressed in the epicardium around the atrioventricular canal and later becomes localized mainly in the mural cells. pdgfrb mutant fish show severe...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (4): dev200082.
Published: 24 February 2022
...:EGFP FACS-sorted cranial NCCs at 48 hpf from wild-type, prdm3 −/− and prdm16 −/− zebrafish . (A) Heatmap showing z-scaled FPKM values for significant genes from prdm3 −/− and prdm16 −/− mutants. (B,D) Volcano plots showing the distribution of DEGs in prdm3 −/− (B) and prdm16 −/− (D...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (4): dev199765.
Published: 22 February 2022
... shear stress tensor is retrieved from the sensor shape, accurately reconstructed through an active contour method. In vitro , within cell aggregates, and in vivo , in the prechordal plate of the zebrafish embryo during gastrulation, our pipeline of techniques demonstrates its efficiency to directly...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (4): dev199667.
Published: 21 February 2022
...Daniel Castranova; Bakary Samasa; Marina Venero Galanternik; Aniket V. Gore; Allison E. Goldstein; Jong S. Park; Brant M. Weinstein ABSTRACT The zebrafish has become a widely used animal model due, in large part, to its accessibility to and usefulness for high-resolution optical imaging. Although...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (4): dev200133.
Published: 18 February 2022
... tissue, which in zebrafish enables subsequent regeneration through paracrine and vascularizing effects. To identify tissue regeneration enhancer elements (TREEs) that control injury-induced epicardial gene expression during heart regeneration, we profiled transcriptomes and chromatin accessibility...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (3): dev200195.
Published: 1 February 2022
... of a hierarchical organization of blood vessels and optimal distribution of blood. However, how these cellular processes are quantitatively coordinated to drive vascular network morphogenesis remains unknown. Here, using the zebrafish vasculature as a model system, we demonstrate that the balanced distribution...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (2): dev199853.
Published: 28 January 2022
... novo β-cell regeneration during induction and recovery from diabetes in zebrafish. We show that the zebrafish has evolved two distinct types of somatostatin-producing δ-cells, which we term δ1- and δ2-cells. Moreover, we characterize a small population of glucose-responsive islet cells, which share...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (2): dev199498.
Published: 18 January 2022
... endothelial-to-hematopoietic transition. The factors and signals that control HSPC fate decisions from the hemogenic endothelium are not fully understood. We found that Vegfc has a role in HSPC emergence from the zebrafish DA. Using time-lapse live imaging, we show that some HSPCs in the DA of vegfc loss...
Includes: Supplementary data