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Keywords: Yolk sac
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Journal Articles
Journal: Development
Development (2019) 146 (23): dev182097.
Published: 05 December 2019
... cells reveals intermediate gastrulation stages that are gradually specified by overlapping transcription factor modules and default smooth muscle fate of FLK1 mesoderm. Single cell RNA sequencing Flk1/Kdr Etv2 Hemangiogenesis Vascular smooth muscle Mouse embryonic stem Yolk sac...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (13): dev152306.
Published: 04 July 2018
... are microglia, suggesting that defective Hoxb8 microglia caused the disorder. What is the source of the Hoxb8 microglia? It has been posited that all microglia progenitors arise at embryonic day (E) 7.5 during yolk sac hematopoiesis, and colonize the brain at E9.5. In contrast, we show the presence of two...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (23): 4341–4351.
Published: 01 December 2016
... transcription. Although the factors regulating EHT in hemogenic endothelium (HE) of the dorsal aorta have been relatively well studied, the molecular regulation of yolk sac HE remains poorly understood. Here, we show that SOX7 inhibits the expression of RUNX1 target genes in HE, while having no effect on RUNX1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (19): 4041–4050.
Published: 01 October 2013
... al., 2004 ), the data presented here clearly show that vessel fusions are restricted to regions where there is strong, pulsatile flow - fusions are absent in capillaries or mutant yolk sacs when flow is reduced - and that fusions result in a rapid change in vessel diameter that establishes...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (6): 1017–1031.
Published: 15 March 2011
... lineage. By contrast, hematopoietic cells express a number of lineage-specific markers that are absent from the endothelium. Since the late 19th century, anatomical studies of the yolk sac in different species have suggested that blood islands are clonal structures. In histological sections, early...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (17): 2829–2839.
Published: 01 September 2010
... populations that can be isolated based on temporal patterns of emergence. The earliest arising population displays characteristics of yolk sac hematopoiesis, whereas a late developing Flk1-positive population appears to reflect the para-aortic splanchnopleura hematopoietic program, as it has reduced primitive...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (15): 2947–2959.
Published: 01 August 2006
.... Remarkably, microsurgical perturbation of the wild-type allantoic core phenocopied the T C /T C vascularization defect, providing further support that an intact core is essential for vascularization. Last, abnormalities were observed in the T C /T C heart and yolk sac, recently reported sites of T...
Journal Articles
Journal: Development
Development (2006) 133 (10): 2041–2051.
Published: 15 May 2006
... in stromal co-cultures arose as early as E8.5, i.e. prior to establishment of the circulation within the paraaortic splanchnopleura (P-Sp). These cells were Tie2 + RAG1 - CD34 Lo/- Kit + CD41 - . While yolk sac (YS) also contained lymphopoietic cells after E9.5, CD41 + YS cells from ⩽25-somite embryos...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (18): 4179–4191.
Published: 15 September 2005
...Samir Taoudi; Aline M. Morrison; Hirofumi Inoue; Ruby Gribi; Janice Ure; Alexander Medvinsky The yolk sac and the para-aortic splanchnopleura/aorta-genital ridges-mesonephros (P-Sp/AGM) region are the main sites of haematopoietic activity in the mouse embryo at the pre-liver stage of development...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (2): 405–414.
Published: 15 January 2005
...Robert Spoelgen; Annette Hammes; Uwe Anzenberger; Dietmar Zechner; Olav M. Andersen; Boris Jerchow; Thomas E. Willnow Megalin is a low-density lipoprotein receptor-related protein (LRP2)expressed in the neuroepithelium and the yolk sac of the early embryo. Absence of megalin expression in knockout...
Journal Articles
Journal: Development
Development (2004) 131 (24): 6237–6247.
Published: 15 December 2004
... or activin receptor like kinase (ALK) 1 die at mid-gestation as a result of defects in the yolk sac vasculature. Here, we have analyzed TGFβsignalling in yolk sacs from endoglin knockout mice and from mice with endothelial-specific deletion of the TGFβ type II receptor (TβRII)or ALK5. We show that TGFβ/ALK5...
Journal Articles
Journal: Development
Development (2004) 131 (10): 2485–2496.
Published: 15 May 2004
... postimplantation development. Therefore, in this study, we explored the effects of NO during vascular development of the murine yolk sac, which begins shortly after implantation. Establishment of the vitelline circulation is crucial for normal embryonic growth and development. Moreover, functional inactivation...
Journal Articles
Journal: Development
Development (2004) 131 (9): 2195–2204.
Published: 01 May 2004
..., we generated a Hand1 knockout mouse. Hand1 -null mice survived to the nine somite stage at which time they succumbed to numerous developmental defects. One striking defect in Hand1 -null embryos was the accumulation of hematopoietic cells between the yolk sac and the amnion because of defects...
Journal Articles
Journal: Development
Development (2003) 130 (10): 2263–2273.
Published: 15 May 2003
... to study the role of this gene during development and disease, we produced a mutation in the mouse ortholog, Tbx3 . The phenotype of the mutant mice verifies the role of this gene in limb and mammary gland development, and, in addition, reveals a previously unknown role for the gene in the yolk sac...
Journal Articles
Journal: Development
Development (2002) 129 (21): 4891–4899.
Published: 01 November 2002
... of the aorta-gonadmesonephros (AGM) region and the yolk sac to produce/expand definitive HSC/RUs during days 11-12 of embryogenesis. We show that the capacity of the AGM region to generate definitive HSC/RUs is high on 11 d.p.c. but significantly reduced by 12 d.p.c. Conversely, at 12 d.p.c. the YS acquires...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2002) 129 (17): 4147–4157.
Published: 01 September 2002
...Estelle Oberlin; Manuela Tavian; Istvàn Blazsek; Bruno Péault Hematopoietic cells arise first in the third week of human ontogeny inside yolk sac developing blood vessels, then, one week later and independently, from the wall of the embryonic aorta and vitelline artery. To address the suggested...
Journal Articles
Journal: Development
Development (2002) 129 (2): 361–372.
Published: 15 January 2002
...Noah Byrd; Sandy Becker; Peter Maye; Roopa Narasimhaiah; Benoit St-Jacques; Xiaoyan Zhang; Jill McMahon; Andrew McMahon; Laura Grabel Blood islands, the precursors of yolk sac blood vessels, contain primitive erythrocytes surrounded by a layer of endothelial cells. These structures differentiate...
Journal Articles
Journal: Development
Development (1986) 97 (1): 63–74.
Published: 01 September 1986
..., Shinshu University, Minamiminowa, Nagano-ken 399-45, Japan. 24 4 1986 Copyright © 1986 by Company of Biologists 1986 vitamin D vitamin K shell-less chick embryo calcium deficiency chorioallantoic membrane yolk sac calcium transport /. Embryol. exp. Morph. 97, 63-74 (1986) 63...
Journal Articles
Journal: Development
Development (1985) 86 (1): 125–141.
Published: 01 April 1985
... as parietal and visceral yolk sac elements. On the basis of the presented data the tumour stem cells were considered as representing malignant equivalents of the common precursor of trophoblastic, visceral and parietal yolk sac cells most likely corresponding to trophectoderm. Accordingly, the tumour...
Journal Articles
Journal: Development
Development (1985) 86 (1): 205–218.
Published: 01 April 1985
... of gestation. The major sites of synthesis in mouse foetuses are the visceral yolk sac (VYS) and liver (Adamson, 1982). We now report that other murine foetal tissues synthesize readily detectable amounts, namely lung, spleen, spinal cord and rib cage. Very low levels are also synthesized by the brain, muscle...