..., and rigidity of the extracellular matrix (ECM). The Mps one binder kinase activator (MOB) adaptor proteins are core components of Hippo signaling and influence Yes-associated protein 1 (YAP1) and transcriptional co-activator with PDZ-binding motif (TAZ), which are potent transcriptional regulators. YAP1/TAZ...

... is implicated in myotube formation and, together with YAP/Taz/Tead1, is associated with reduced muscle fiber diameter of a subset of fast fibers. Axin2 Yap1 Wwtr1 Tead1 Skeletal muscle Muscle fibers Satellite cells The Wnt gene family encodes 19 secreted glycoproteins, which bind...

... Vertebrae Somite Chondrocyte Yap1 Taz (Wwtr1) Mouse Fat4 and Dchs1 are protocadherins that act as a receptor-ligand pair to play key roles during embryonic development. Gene inactivation of either Fat4 or Dchs1 in mice results in a wide spectrum of phenotypes ranging from branching...

[email protected] ) Competing interests statement The authors declare no competing financial interests. 5 6 2013 © 2013. Published by The Company of Biologists Ltd 2013 Radial glial cells Neurogenesis Archicortex Mouse Yap1 Wwtr1 Neurofibromatosis type 2 (NF2...

... that mouse Tead proteins regulate cell proliferation by mediating Hippo signaling. In NIH3T3 cells, cell density and Hippo signaling regulated the activity of endogenous Tead proteins by modulating nuclear localization of a Yki homolog, Yap1, and the resulting change in Tead activity altered cell...