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Keywords: Yap
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Journal Articles
Journal Articles
Journal: Development
Development (2022) 149 (24): dev200988.
Published: 21 December 2022
... remain dependent on XAV939. Rather than inhibiting Wnt, we found that XAV939 prevents TE induction by reducing activation of YAP, a co-factor of TE-inducing TEAD transcription factors. Tankyrase inhibition stabilises angiomotin, which limits nuclear accumulation of YAP. Upon deletion of angiomotin-family...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2020) 147 (21): dev187187.
Published: 12 November 2020
...Hannah K. Vanyai; Fabrice Prin; Oriane Guillermin; Bishara Marzook; Stefan Boeing; Alexander Howson; Rebecca E. Saunders; Thomas Snoeks; Michael Howell; Timothy J. Mohun; Barry Thompson; Sally Dunwoodie; John Wallingford ABSTRACT The Hippo-YAP/TAZ pathway is an important regulator of tissue growth...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2020) 147 (8): dev179069.
Published: 27 April 2020
... transcriptional co-activators Yorkie, YAP and TAZ is far more dynamic than previously appreciated, and YAP and TAZ are also regulated by liquid-liquid phase separation. Here, we review our current understanding of Yorkie, YAP and TAZ regulation, with a focus on recent microscopy-based studies. References...
Journal Articles
Journal Articles
Journal: Development
Development (2019) 146 (18): dev167106.
Published: 16 September 2019
...John Robert Davis; Nicolas Tapon ABSTRACT The Hippo signalling pathway and its transcriptional co-activator targets Yorkie/YAP/TAZ first came to attention because of their role in tissue growth control. Over the past 15 years, it has become clear that, like other developmental pathways (e.g...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (9): dev175810.
Published: 1 May 2019
...Benjamin J. van Soldt; Jun Qian; Jiao Li; Nan Tang; Jining Lu; Wellington V. Cardoso ABSTRACT Although the Hippo–yes-associated protein (Yap) pathway has been implicated in lung development, the specific roles for Yap and its nucleocytoplasmic shuttling in the developing airway and alveolar...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (2): dev166454.
Published: 16 January 2019
... pathway (nuclear Yap) or ablation of Yap result in increased β-catenin and Fgf10 signaling, suggesting a cytoplasmic role for Yap in epithelial lineage commitment. We further demonstrate redundant and non-redundant functions for the two nuclear effectors of the Hippo pathway, Yap and Taz, during lung...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (10): dev159210.
Published: 17 May 2018
... heart development reveals its role in compact wall maturation and trabeculation, as well as in modulation of the cardiomyocyte actomyosin network and cell-cell junctions. Heart development Hippo pathway Yap Taz Wwtr1 Trabeculation Cardiac trabeculation is an important step to cardiac...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2016) 143 (13): 2398–2409.
Published: 1 July 2016
...Zhihui Huang; Jinxia Hu; Jinxiu Pan; Ying Wang; Guoqing Hu; Jiliang Zhou; Lin Mei; Wen-Cheng Xiong ‪YAP (yes-associated protein), a key transcriptional co-factor that is negatively regulated by the Hippo pathway, is crucial for the development and size control of multiple organs, including...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (17): 2962–2971.
Published: 1 September 2015
... arteries and cranial vasculature during embryonic development. Neural crest-specific deletion of the Hippo effectors Yap and Taz produces neural crest precursors that migrate normally, but fail to produce vascular smooth muscle, and Notch target genes such as Jagged1 fail to activate normally. We show...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (15): 2696–2703.
Published: 1 August 2015
... use a conditional knockout approach to inactivate within the nephric duct (ND) lineage the two effectors of the Hippo pathway, Yap and Taz . Deletion of Yap leads to hydronephrotic kidneys with blind-ending megaureters at birth. In Yap mutants, the ND successfully migrates towards, and contacts...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (6): 1197–1208.
Published: 15 March 2014
... modulated remains relatively unknown. Here we show that planarians use the downstream effector of the Hippo signaling cascade, yorkie ( yki ; YAP in vertebrates) to control a diverse set of pleiotropic processes in organ homeostasis, stem cell regulation, regeneration and axial patterning. We show that yki...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (20): 3383–3391.
Published: 15 October 2010
.... , Kiyonari H. , Ota M. , Ralston A. , Yabuta N. , Hirahara S. , Stephenson R. O. , Ogonuki N. , et al . ( 2009 ). The hippo signaling pathway components lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass . Dev. Cell 16 , 398...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (14): 2397–2408.
Published: 15 July 2010
..., but does not arrest, neuroepithelial cell cycle induces premature neurogenesis . J. Cell Sci. 116 , 4947 - 4955 . Cao X. , Pfaff S. L. , Gage F. H. ( 2008 ). YAP regulates neural progenitor cell number via the TEA domain transcription factor . Genes Dev. 22 , 3320 - 3334...
Includes: Supplementary data