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Keywords: YAK1
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Journal Articles
Adam Barrada, Meriem Djendli, Thierry Desnos, Raphael Mercier, Christophe Robaglia, Marie-Hélène Montané, Benoît Menand
Journal:
Development
Development (2019) 146 (3): dev171298.
Published: 7 February 2019
... regulated kinase)/YAK1 kinase are resistant to AZD-8055 and, reciprocally, that YAK1 overexpressors are hypersensitive to AZD-8055. Significantly, these phenotypes were conditional on TOR inhibition, positioning YAK1 activity downstream of TOR. We further show that the ATP-competitive DYRK1A inhibitor pINDY...
Includes: Supplementary data
