... findings that flex mutations fail to suppress even the weakest Sxl M alleles, arguing against the proposed regulatory relationship between flex and Sxl . Instead we show that the lethal flex phenotype depends on the absence of a Y chromosome, not on the presence of two X chromosomes. flex lethality...

...Claude M. Nagamine; Cherlynn Carlisle ABSTRACT The Y chromosome from certain populations of M. m. domesticus is incapable of normal testis determination in the B6 inbred strain resulting in XY hermaphrodites or XY females (XY DOM sex reversal). B6 consomic strains have been developed with either...

... appeared to have occurred subsequent to the infection. Some of the XY females proved to be fertile, and the mutant phenotype was found to segregate exclusively with the Y chromosome. Analysis of the offspring also confirmed the absence of any retroviral insertion that could be correlated with the mutation...

..., physiology and behaviour. Males and females also differ in sex chromosome constitution: males have a single X chromosome and a Y chromosome; females have two X chromosomes. Using Drosophila species as a model, it was assumed that sex in mammals would depend on X-chromosome dosage; however, with improved...

...Robert P. Erickson; Edward J. Durbin; Laura L. Tres ABSTRACT Mice provide material for studies of Y-chromosomal and autosomal sequences involved in sex determination. Eicher and coworkers have identified four subregions in the mouse Y chromosome, one of which corresponds to the Sxr fragment...

...Kirby D. Smith; Keith E. Young; C. Conover Talbot, Jr; Barbara J. Schmeckpeper ABSTRACT A significant fraction of the human Y chromosome is composed of DNA sequences which have homologues on the X chromosome or autosomes in humans and non-human primates. However, most human Y-chromosome sequences...

...P. Leroy; E. Seboun; M. G. Mattei; M. Fellous; C. E. Bishop ABSTRACT A genomic sequence ( 12f3), derived from the long arm of the human Y chromosome, detects a 1-6 kb mRNA, expressed in human and mouse testis, but not in other tissues tested by Northern blot analysis. Using 12f3 as a probe, a mouse...

... and by in situ hybridization to Xp22.3; a localization coincident with the previously identified locus for STS expression. Although no significant hybridization of this clone to the Y chromosome was observed, p422 has been used to isolate a longer cDNA clone and genomic sequences which do recognize Y-specific...

... by their monozygosity in the male and the absence of a Y chromosome in the female. In the case of both the X and the Y chromosomes, a large set of anonymous DNA markers have been assigned to these chromosomes and localized or mapped cytogenetically or by recombination. In the case of the Y chromosome, the rationale...

...Paul S. Burgoyne ABSTRACT All aspects of the mammalian male phenotype are due either directly or indirectly to Y-chromosome activity. This review summarizes what is known of the role of the Y in male germ cell differentiation in the mouse. The initial diversion of germ cells to the male pathway...

...Albert De La Chapelle ABSTRACT It has been conclusively shown that a majority of XX males has acquired Y-chromosome-specific DNA (Y-DNA) sequences from their father’s Y chromosome. Testicular differentiation in these XX males is very likely induced by the testis-determining factor, TDF , normally...

...David C. Page ABSTRACT The role of the human Y chromosome in the etiology of gonadoblastoma, a gonadal neoplasm, is considered and a two-part model is presented. According to this hypothesis: (1) There is a gene on the Y chromosome that strongly predisposes dysgenetic gonads to develop...