... gastrulation and mesoderm formation, but not axial patterning. Injection of Xwnt8 mRNA (acting upstream of β-catenin and thus substitutes for the dorsal determinant)did not restore axial development in PBEs. Simultaneous injections of Xwnt8 and VegT into PBEs resulted in dorsal axis development, showing...

... with a candidate protein and cultured in dispersion. We have tested a number of candidate factors and we find that only eFGF protein is able to mediate a community effect, stimulating stable muscle-specific gene expression in demonstrably single muscle precursor cells. In contrast, Xwnt8, bFGF, BMP4 and TGFβ2 do...