.... To shed light on the molecular cascade that leads to the repression of the Wnt pathway, we looked for individual organiser genes whose overexpression could complement the inhibition of BMP signalling to promote notochord formation in the secondary trunks. Two genes, gsc and Xnot , were thus identified...

... muscle development, and that cells can be recruited to the notochord by environmental signals. * Author for correspondence (e-mail: amacher@uoneuro.uoregon.edu ) 18 03 1998 02 02 1998 © 1998 by Company of Biologists 1998 floating head spadetail Xnot not genes...

... midline, in which most cells generate clones that develop exclusively as notochord. The borders of the notochord domain are sharp at the level of single cells, and coincide almost exactly with the border of the expression domain of the homeobox gene floating head ( flh ; zebrafish homologue of Xnot...