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Keywords: Xenopus
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Journal Articles
Journal: Development
Development dev.199441.
Published: 28 April 2021
... lethality. Here, we showed that kindlin2 is essential for neural crest (NC) formation in Xenopus embryos. Loss-of-function assays performed with kindlin2- specific morpholino antisense oligos (MOs) or clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 techniques...
Journal Articles
Journal: Development
Development (2021) 148 (18): dev198960.
Published: 29 March 2021
...Martina Nagel; Debanjan Barua; Erich W. Damm; Jubin Kashef; Ralf Hofmann; Alexey Ershov; Angelica Cecilia; Julian Moosmann; Tilo Baumbach; Rudolf Winklbauer ABSTRACT During Xenopus gastrulation, leading edge mesendoderm (LEM) advances animally as a wedge-shaped cell mass over the vegetally moving...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (4): dev193227.
Published: 16 February 2021
...Aditi Dubey; Jianshi Yu; Tian Liu; Maureen A. Kane; Jean-Pierre Saint-Jeannet ABSTRACT All paired sensory organs arise from a common precursor domain called the pre-placodal region (PPR). In Xenopus , Zic1 non-cell autonomously regulates PPR formation by activating retinoic acid (RA) production...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (2): dev195008.
Published: 26 January 2021
... (NTDs) such as anencephaly and spina bifida. Here, we have combined analysis of neural tube closure in mouse and in the African Clawed Frog Xenopus laevis to elucidate the etiology of Lrp2-related NTDs. Lrp2 loss of function impaired neuroepithelial morphogenesis, culminating in NTDs that impeded...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (2): dev184341.
Published: 19 January 2021
... craniofacial structures and other tissues containing neural crest (NC)-derived cells, we hypothesized that DDX3 is also important for NC development. Using Xenopus tropicalis as a model, we show that DDX3 is required for normal NC induction and craniofacial morphogenesis by regulating AKT kinase activity...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (17): dev188094.
Published: 11 September 2020
... families. No new classes of extracellular mesoderm-inducing factors have been identified in more than two decades. Here, we show that the pinhead ( pnhd ) gene encodes a secreted protein that is essential for the activation of a subset of mesodermal markers in the Xenopus embryo. RNA sequencing revealed...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (10): dev189324.
Published: 27 May 2020
... unstudied. Here, we describe a novel function of Rspo2 in FGF pathway regulation in vivo . Overexpressed Rspo2 inhibited elongation of Xenopus ectoderm explants and Erk1 activation in response to FGF. By contrast, the constitutively active form of Mek1 stimulated Erk1 even in the presence of Rspo2...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (10): dev186338.
Published: 22 May 2020
... control cell movement. The Rho guanine exchange factor (GEF) Trio is especially well suited to relay signals, as it features distinct catalytic domains to activate Rho GTPases. Here, we show that Trio is required for Xenopus cranial neural crest (NC) cell migration and cartilage formation. Trio cell...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (6): dev180844.
Published: 19 March 2020
...Lauren S. Phipps; Lindsey Marshall; Karel Dorey; Enrique Amaya ABSTRACT Understanding how to promote organ and appendage regeneration is a key goal of regenerative medicine. The frog, Xenopus , can achieve both scar-free healing and tissue regeneration during its larval stages, although it...
Journal Articles
Journal: Development
Development (2020) 147 (3): dev185496.
Published: 05 February 2020
... immune cells and inflammation can help develop strategies to promote tissue repair and regeneration. Here, we took advantage of naturally occurring tail regeneration-competent and -incompetent developmental stages of Xenopus tadpoles. We first establish the essential role of the myeloid lineage for tail...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (15): dev179580.
Published: 09 August 2019
...Rachel A. S. Kjolby; Marta Truchado-Garcia; Suvruta Iruvanti; Richard M. Harland ABSTRACT During Xenopus gastrulation, Wnt and FGF signaling pathways cooperate to induce posterior structures. Wnt target expression around the blastopore falls into two main categories: a horseshoe shape with a dorsal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (8): dev172700.
Published: 23 April 2019
... proteasomes are present in a gradient with the highest levels in the animal hemisphere and extending into the vegetal hemisphere of Xenopus oocytes. This distribution changes dramatically during the oocyte-to-embryo transition, with proteasomes becoming enriched in and restricted to the animal hemisphere and...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (3): dev166884.
Published: 01 February 2019
..., axolotl and Xenopus laevis , in as little as 1-5 days, while preserving a broad range of fluorescent proteins, including GFP, mCherry, Brainbow and Alexa-conjugated fluorophores. Ethyl cinnamate is non-toxic and can easily be used in multi-user microscope facilities. This method opens up tissue clearing...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (24): dev168922.
Published: 12 December 2018
...) gene plekhg5 as an essential regulator of apical constriction of bottle cells during Xenopus gastrulation. plekhg5 is expressed in the blastopore lip and its expression is sufficient to induce ectopic bottle cells in epithelia of different germ layers in a Rho-dependent manner. This activity is not...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (23): dev159889.
Published: 28 November 2018
... in the chromatin modifier gene WDR5 . WDR5 acts as a scaffolding protein in the H3K4 methyltransferase complex, but a role in LR patterning is unknown. Here, we show that Wdr5 depletion leads to LR patterning defects in Xenopus via its role in ciliogenesis. Unexpectedly, we find a dual role for WDR5...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (20): dev166710.
Published: 26 October 2018
... that Fam46a is expressed in the PPE in Xenopus embryos, and Fam46a knockdown induces abnormalities in the eye formation and the body color. At the neurula stage, Fam46a upregulates the expression of PPE genes and inhibits neural crest formation. We also show that Fam46a physically interacts with Smad1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (20): dev166181.
Published: 18 October 2018
... spleen agenesis remain unknown, in part due to the lack of a suitable animal model for study. Here we reveal that RPSA is required for normal spleen development in the frog, Xenopus tropicalis . Depletion of Rpsa in early embryonic development disrupts pre-rRNA processing and ribosome biogenesis, and...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (18): dev147769.
Published: 17 September 2018
... instructive signal in mesoderm formation during gastrulation. Here, we show in Xenopus that RARγ is indispensable for the expression of early mesoderm markers and is, therefore, an obligatory factor in mesodermal competence and/or maintenance. We identified several novel targets upregulated by RA receptor...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (15): dev163386.
Published: 08 August 2018
... preserve their developmental potential remain poorly understood. Here, we explore the role of histone deacetylase (HDAC) activity in this process in Xenopus . We show that HDAC activity is essential for the formation of neural crest, as well as for proper patterning of the early ectoderm. The requirement...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (14): dev159368.
Published: 17 July 2018
... restricts dorsoanterior development in Xenopus . We found that Notch1 has ventralizing properties and abolishes the dorsalizing activity of β-catenin by reducing its steady state levels, in a process that does not require β-catenin phosphorylation by glycogen synthase kinase 3β. In the present work, we...
Includes: Supplementary data