... with their in vitro culture have resulted in an under-representation of female mESCs in the literature. Recent studies show that the second X chromosome in female, and more specifically the transcriptional activity from both of these chromosomes due to absent X chromosome inactivation, sets female and male mESCs...

... by The Company of Biologists Ltd 2022 Summary: Absence of SmcHD1 in mouse epiblast stem cells and embryonic fibroblasts leads to a loss of histone H3K9me3 enrichment on the inactive X chromosome, revealing a crucial role of SmcHD1 in X chromosome inactivation. X chromosome inactivation...

...Catherine Patrat; Jean-François Ouimette; Claire Rougeulle ABSTRACT X chromosome inactivation (XCI) is a key developmental process taking place in female mammals to compensate for the imbalance in the dosage of X-chromosomal genes between sexes. It is a formidable example of concerted gene...

.../bioinformatics/btp579 Escamilla-Del-Arenal , M. , da Rocha , S. T. and Heard , E. ( 2011 ). Evolutionary diversity and developmental regulation of X-chromosome inactivation . Hum. Genet.   130 , 307 - 327 . 10.1007/s00439-011-1029-2 Gontan , C. , Achame , E. M. , Demmers...

...). References Augui , S. , Nora , E. P. and Heard , E. ( 2011 ). Regulation of X-chromosome inactivation by the X-inactivation centre . Nat. Rev. Genet.   12 , 429 - 442 . 10.1038/nrg2987 Celtikci , B. , Leclerc , D. , Lawrance , A. K. , Deng , L. , Friedman , H. C...

.... Depending on the developmental time window, imprinted or random X chromosome inactivation (XCI) is initiated, and both processes lead to an inactive X chromosome that is clonally inherited. Here, we review new insights into the life cycle of XCI and provide an overview of the mechanisms regulating X...

...Joshua W. Mugford; Della Yee; Terry Magnuson Proper regulation of X-linked gene expression, termed dosage compensation, is required for the normal development of mammalian embryos. Through the process of X chromosome inactivation (XCI), somatic cells of mammalian females inactivate one of their two...

... inactivation De novo DNA methyltransferases Xist It is well known that DNA methylation plays an important role(s) in the regulation of gene expression, maintenance of genomic integrity, parental imprinting and X chromosome inactivation (X-inactivation). It is thought that the methylation pattern...

...-mail: [email protected] ) 10 05 2000 23 03 2000 © 2000 by Company of Biologists 2000 Preimplantation mouse embryo X chromosome inactivation Chromatin Histone X inactivation involves several changes in the structure or properties of the inactive X chromosome...

... trophectoderm derivatives (ectoplacental cone and extraembryonic ectoderm) are severely affected, but the primitive endoderm derivatives (visceral and parietal endoderm) are relatively unaffected. Successful rescue of DsX M embryos by aggregation with tetraploid embryos show that X chromosome inactivation...

... 12 1994 © 1995 by Company of Biologists 1995 cerebral cortex mouse clonal analysis genetic mosaics X chromosome inactivation We previously described a novel method of labelling cortical progenitors without the need for surgical intervention but which instead relies upon...

... are found only in the nucleus is suggestive of a nuclear function, but does not rule out the possibility that transcription of Xist is a consequence of the initiation of X chromosome inactivation rather than a cause, or that the act of transcription rather than the RNA product is important in XCI, as has...

.... , Lovell-Badge , R. and Kay , G. ( 1991 ). X-chromosome inactivation may explain the difference in viability of XO humans and mice . Nature 351 , 406 – 408 . 10.1038/351406a0 Auffray , C. and Rougeon , F. ( 1980 ). Purification of mouse immunoglobin heavy chain messenger...

... ), pp. 95 – 98 . Canberra : Australian Academy of Science . Lyon , M. F. and Rastan , S. ( 1984 ). Parental source of chromosome imprinting and its relevance to X chromosome inactivation . Differentiation 26 , 63 – 67 . Mcburney , M. W. and Strutt , B. J. ( 1980...