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Keywords: Wt1
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Journal Articles
Journal: Development
Development (2021) 148 (10): dev199460.
Published: 20 May 2021
... of the pulmonary mesothelium in dysregulated lung growth noted in the Wt1 knockout mouse model of CDH. Loss of WT1 leads to intrafetal effusions, altered lung growth, and branching defects prior to normal closure of the diaphragm. We found significant differences in key genes; however, when Wt1 null lungs were...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (9): dev197525.
Published: 10 May 2021
...://creativecommons.org/licenses/by/4.0 ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. To quantify WT1 cells in the epicardium, WT1 + nuclei and all DAPI-stained nuclei labeled with PDPN were manually counted. For each sample...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (20): dev178723.
Published: 17 October 2019
... a crucial role in embryonic heart development and adult heart repair; however, the molecular events underlying its maturation remain unknown. Wt1 , one of the main markers of the embryonic epicardium, is essential for epicardial development and function. Here, we analyse the transcriptomic profile...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (16): 2862–2872.
Published: 15 August 2017
...Nicholas D. Hastie ABSTRACT The study of genes mutated in human disease often leads to new insights into biology as well as disease mechanisms. One such gene is Wilms’ tumour 1 ( WT1 ), which plays multiple roles in development, tissue homeostasis and disease. In this Primer, I summarise how...
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2017) 144 (1): 44–53.
Published: 1 January 2017
... gonads, but the mechanisms that control their differentiation during gonad development remain elusive. In this study, we found that deletion of Wt1 in the ovary after sex determination caused ectopic development of steroidogenic cells at the embryonic stage. Furthermore, differentiation of both Sertoli...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (11): 2271–2278.
Published: 1 June 2014
... been identified, including sonic hedgehog, bone morphogenetic protein 4 and multiple members of the Wnt/β-catenin signaling pathway. However, the regulation of these factors, including their induction, remains poorly understood. Here, we identify a crucial role for the Wilms' tumor 1 protein (WT1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (13): 2330–2339.
Published: 1 July 2012
..., Pax2 or Wt1 gene function in the metanephric mesenchyme compromises the formation of the kidney. Moreover, it has been shown that the Hox11-Eya1-Pax2 complex activates the expression of Six2 and Gdnf in the metanephric mesenchyme to drive nephrogenesis. Here, we demonstrate that the orphan nuclear...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (7): 1189–1203.
Published: 1 April 2010
...Sunny Hartwig; Jacqueline Ho; Priyanka Pandey; Kenzie MacIsaac; Mary Taglienti; Michael Xiang; Gil Alterovitz; Marco Ramoni; Ernest Fraenkel; Jordan A. Kreidberg The Wilms' tumor suppressor 1 ( WT1 ) gene encodes a DNA- and RNA-binding protein that plays an essential role in nephron progenitor...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (10): 1875–1885.
Published: 15 May 2008
...-Catenin stabilization caused changes in Sertoli cell identity and misregulation of inter-Sertoli cell contacts. As Wt1 conditional knockout in Sertoli cells causes similar phenotypes to our stabilized β-catenin mutants, we then investigated the relationship of Wt1 and β-catenin in Sertoli cells and found...
Journal Articles
Journal: Development
Development (2007) 134 (20): 3603–3613.
Published: 15 October 2007
... of these genes but notably reduces expression of Wt1,a transcription factor implicated in spleen morphogenesis and expressed in the mesothelium. These observations place Barx1 proximally within a Wt1 pathway of spleen development and reveal how a homeotic regulator employs different molecular mechanisms to mold...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (24): 5437–5449.
Published: 15 December 2005
... morphogenesis. The mesenchyme produces Gdnf, which stimulates branching, and the ureteric bud stimulates continued growth of the mesenchyme and differentiation of nephrons from the induced mesenchyme. Null mutation of the Wt1 gene eliminates outgrowth of the ureteric bud, but Gdnf has been identified...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (13): 3113–3126.
Published: 1 July 2005
... for correspondence (e-mail: lis2008@med.cornell.edu ) 29 4 2005 ©2005. 2005 Spleen ontogeny Organogenesis Pbx1 Hox11 ( Tlx1 ) Nkx2.5 Nkx3.2 ( Bapx1 ) Pod1 (capsulin, Tcf21) Wt1 Transcriptional regulation Pbx1 targets Proliferation Mouse In vertebrates, the spleen...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (6): 1327–1336.
Published: 15 March 2005
... proliferation and differentiation of neuronal progenitor cells. Here, we report that the Wilms' tumour zinc-finger protein, Wt1, is required for normal formation of the olfactory epithelium. Wt1 was detected by immunohistochemistry in the developing olfactory epithelium of wild-type embryos between gestational...
Journal Articles
Journal: Development
Development (2003) 130 (20): 5031–5042.
Published: 15 October 2003
... culture Notch gamma-secretase DAPT Wt1 Mouse Notch proteins are conserved receptors mediating short-range intercellular communications that allow proper allocation of cell fates during development( Lewis, 1998 ) and in the adult( Brittan and Wright, 2002 ; Gridley, 1997 ; Ohishi et al...