... around wound region. Times are in minutes. Having established the conditions for laser wounding, we next applied this technique to EGFR mutants. A previous wounding experiment of stage 15 embryos demonstrated that wound healing was delayed in EGFR hypomorphic mutants ( Geiger et al., 2011 ). Here...

... in deciphering the molecular and cellular basis of wound healing, tissue repair and regeneration, as well as their implications for future clinical applications. The conference showcased an ever-expanding diversity of model organisms used to identify mechanisms that promote regeneration. Over 25 species were...

... Alveolar bone Periodontal ligament Extracellular matrix Progenitor cell Stem cell Mural cell Single-cell analysis Cell atlas Wound healing Japan Society for the Promotion of Science http://dx.doi.org/10.13039/501100001691 JP15J03981 JP19H01069 JP19K22713 JP19H03830 JP17K19752...

... targeted a relatively restricted stromal domain ( Fig. 3 I), we asked whether Wnts produced by Acta2 + stromal cells also contributed to colonic wound healing. Surprisingly, both Gpr177 L/L ;Acta2-CreER ( n =6) and Gpr177 L/L ;Vil-Cre;Acta2-CreER ( n =6) mice showed increased morbidity ( Fig. 6 B,C...

...Alan Y. Wong; Jessica L. Whited ABSTRACT Striking similarities between wound healing, epimorphic regeneration and the progression of solid tumors have been uncovered by recent studies. In this Review, we discuss systemic effects of tumorigenesis that are now being appreciated in epimorphic...

... injury. This observation hints towards a role for the Eda pathway in controlling the switch from basal to reflex tears, to support corneal wound healing. Collectively, our data suggest a crucial implication of Eda signaling in the cornea–lacrimal gland feedback loop, both in physiological...

... advances in wound healing, repair and regeneration. The meeting covered a wide range of regeneration models and tissues, identification of regulatory genes and signals, and striking advances toward regenerative therapies. Here, we report some of the exciting topics discussed during this conference...

... taken place. Further genetic analysis revealed that the activation of the initiator caspase Dronc is coupled with the generation of reactive oxygen species. The activation of Dronc also regulates myosin levels and delays wound healing. Our findings suggest a possible function for non-apoptotic caspase...

...) and handled as previously described ( James et al., 2006 ). All cell lines were confirmed to be mycoplasma free every ten passages. Many groups have linked inhibition of Wnt signaling to improved wound healing following MI. Transgenic mice overexpressing the Wnt inhibitor SFRP1 showed reduced scar...

... and highlights the diversity of regeneration strategies in different organ systems and species. Cell plasticity and cell reprogramming Blastema dynamics Model systems Immune response Transcriptional control of regeneration Wound healing Injury-induced signaling Senescence and ageing Since...

... by The Company of Biologists Ltd 2016 Summary: Inhibiting fibroblast migration during regeneration in axolotl reveals the importance of fibroblasts for blastema-based limb regeneration but not non-blastemal skin regrowth. Beryllium Regeneration Wound healing Limb development Ambystoma...

... cellular processes that take place both within the epidermis and in other participating tissues. Re-epithelialization of partial- or full-thickness skin wounds of adult zebrafish, however, is extremely rapid and largely independent of the other processes of wound healing. Live imaging after treatment...

... Notch signaling and cell proliferation to maintain normal epithelial thickness. Primary cilia Cornea Ocular surface Notch signaling Epithelium Wound healing Mouse The outermost layer of the cornea consists of a stratified non-keratinized pseudosquamous epithelium known as corneal...

... is essential for: (1) general mRNA translation during embryogenesis, (2) developmental re-programming upon manipulations to the embryo and (3) larval wound healing. We also learned that Vasa interacted with mRNAs in the perinuclear area and at the spindle in an Importin-dependent manner during cell cycle...

... The authors declare no competing financial interests. 12 12 2013 15 5 2014 © 2014. Published by The Company of Biologists Ltd 2014 Epithelial morphogenesis Junctional dynamics Mechanical forces Quantitative image analysis Segmentation algorithms Wound healing Drosophila...

... and epidermal movement in embryonic wound-healing . Nature 360 , 179 - 183 . 10.1038/360179a0 Martin P. , Parkhurst S. M. ( 2004 ). Parallels between tissue repair and embryo morphogenesis . Development 131 , 3021 - 3034 . 10.1242/dev.01253 Martin A. C. , Kaschube M...

...Barbara A. Schmidt; Valerie Horsley Acute wound healing in the skin involves the communication of multiple cell types to coordinate keratinocyte and fibroblast proliferation and migration for epidermal and dermal repair. Many studies have focused on the interplay between hematopoietic cells...

.... 217 , 206 – 216 . Ansell D. M. , Kloepper J. E. , Thomason H. A. , Paus R. , Hardman M. J. ( 2011 ). Exploring the ‘hair growth-wound healing connection’: anagen phase promotes wound re-epithelization . J. Invest. Dermatol. 131 , 512 – 528 . Blanpain C...

...,and inhibition of cell motility and in vitro wound healing. Although the rate of cell proliferation was reduced, terminal differentiation was unaffected. To assess the role of Necl2 in vivo, we examined the epidermis of Necl2 -null mice and developed transgenic mice that expressed Necl2 in the basal layer...

... © 2009. 2009 Drosophila Fascin (Singed) Hemocytes Migration Wound healing The dynamic regulation of cell shape underlies many cell behaviors, in particular that of cell migration, which in turn is pivotal for the development and maintenance of animal tissues. However, the ways...