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Keywords: Wound healing
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Journal Articles
Journal: Development
Development (2023) 150 (5): dev201231.
Published: 9 March 2023
... around wound region. Times are in minutes. Having established the conditions for laser wounding, we next applied this technique to EGFR mutants. A previous wounding experiment of stage 15 embryos demonstrated that wound healing was delayed in EGFR hypomorphic mutants ( Geiger et al., 2011 ). Here...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2023) 150 (3): dev201579.
Published: 31 January 2023
... in deciphering the molecular and cellular basis of wound healing, tissue repair and regeneration, as well as their implications for future clinical applications. The conference showcased an ever-expanding diversity of model organisms used to identify mechanisms that promote regeneration. Over 25 species were...
Journal Articles
Journal Articles
Journal: Development
Development (2022) 149 (1): dev199587.
Published: 12 January 2022
... targeted a relatively restricted stromal domain ( Fig. 3 I), we asked whether Wnts produced by Acta2 + stromal cells also contributed to colonic wound healing. Surprisingly, both Gpr177 L/L ;Acta2-CreER ( n =6) and Gpr177 L/L ;Vil-Cre;Acta2-CreER ( n =6) mice showed increased morbidity ( Fig. 6 B,C...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (1): dev181636.
Published: 2 January 2020
...Alan Y. Wong; Jessica L. Whited ABSTRACT Striking similarities between wound healing, epimorphic regeneration and the progression of solid tumors have been uncovered by recent studies. In this Review, we discuss systemic effects of tumorigenesis that are now being appreciated in epimorphic...
Journal Articles
Journal: Development
Development (2019) 146 (14): dev176693.
Published: 16 July 2019
... injury. This observation hints towards a role for the Eda pathway in controlling the switch from basal to reflex tears, to support corneal wound healing. Collectively, our data suggest a crucial implication of Eda signaling in the cornea–lacrimal gland feedback loop, both in physiological...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (9): dev176974.
Published: 8 May 2019
... advances in wound healing, repair and regeneration. The meeting covered a wide range of regeneration models and tissues, identification of regulatory genes and signals, and striking advances toward regenerative therapies. Here, we report some of the exciting topics discussed during this conference...
Journal Articles
Journal Articles
Journal: Development
Development (2018) 145 (1): dev159905.
Published: 8 January 2018
...) and handled as previously described ( James et al., 2006 ). All cell lines were confirmed to be mycoplasma free every ten passages. Many groups have linked inhibition of Wnt signaling to improved wound healing following MI. Transgenic mice overexpressing the Wnt inhibitor SFRP1 showed reduced scar...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (3): 357–364.
Published: 1 February 2017
... and highlights the diversity of regeneration strategies in different organ systems and species. Cell plasticity and cell reprogramming Blastema dynamics Model systems Immune response Transcriptional control of regeneration Wound healing Injury-induced signaling Senescence and ageing Since...
Journal Articles
Journal: Development
Development (2016) 143 (19): 3491–3505.
Published: 1 October 2016
... by The Company of Biologists Ltd 2016 Summary: Inhibiting fibroblast migration during regeneration in axolotl reveals the importance of fibroblasts for blastema-based limb regeneration but not non-blastemal skin regrowth. Beryllium Regeneration Wound healing Limb development Ambystoma...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (12): 2077–2088.
Published: 15 June 2016
... cellular processes that take place both within the epidermis and in other participating tissues. Re-epithelialization of partial- or full-thickness skin wounds of adult zebrafish, however, is extremely rapid and largely independent of the other processes of wound healing. Live imaging after treatment...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (12): 2160–2171.
Published: 15 June 2016
... Notch signaling and cell proliferation to maintain normal epithelial thickness. Primary cilia Cornea Ocular surface Notch signaling Epithelium Wound healing Mouse The outermost layer of the cornea consists of a stratified non-keratinized pseudosquamous epithelium known as corneal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (11): 1960–1970.
Published: 1 June 2015
... is essential for: (1) general mRNA translation during embryogenesis, (2) developmental re-programming upon manipulations to the embryo and (3) larval wound healing. We also learned that Vasa interacted with mRNAs in the perinuclear area and at the spindle in an Importin-dependent manner during cell cycle...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (14): 2901–2911.
Published: 15 July 2014
... The authors declare no competing financial interests. 12 12 2013 15 5 2014 © 2014. Published by The Company of Biologists Ltd 2014 Epithelial morphogenesis Junctional dynamics Mechanical forces Quantitative image analysis Segmentation algorithms Wound healing Drosophila...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (9): 1814–1820.
Published: 1 May 2014
... and epidermal movement in embryonic wound-healing . Nature 360 , 179 - 183 . 10.1038/360179a0 Martin P. , Parkhurst S. M. ( 2004 ). Parallels between tissue repair and embryo morphogenesis . Development 131 , 3021 - 3034 . 10.1242/dev.01253 Martin A. C. , Kaschube M...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (7): 1517–1527.
Published: 1 April 2013
...Barbara A. Schmidt; Valerie Horsley Acute wound healing in the skin involves the communication of multiple cell types to coordinate keratinocyte and fibroblast proliferation and migration for epidermal and dermal repair. Many studies have focused on the interplay between hematopoietic cells...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2009) 136 (20): 3505–3514.
Published: 15 October 2009
...,and inhibition of cell motility and in vitro wound healing. Although the rate of cell proliferation was reduced, terminal differentiation was unaffected. To assess the role of Necl2 in vivo, we examined the epidermis of Necl2 -null mice and developed transgenic mice that expressed Necl2 in the basal layer...
Journal Articles
Journal: Development
Development (2009) 136 (15): 2557–2565.
Published: 1 August 2009
... © 2009. 2009 Drosophila Fascin (Singed) Hemocytes Migration Wound healing The dynamic regulation of cell shape underlies many cell behaviors, in particular that of cell migration, which in turn is pivotal for the development and maintenance of animal tissues. However, the ways...
Includes: Multimedia, Supplementary data