...Yuji Atsuta; Yoshiko Takahashi The Müllerian duct (MD) and Wolffian duct (WD) are embryonic tubular tissues giving rise to female and male reproductive tracts, respectively. In amniote embryos, both MD and WD emerge in both sexes, but subsequently degenerate in the males and females, respectively...

... undefined. An evaluation of previously generated T-Cre-mediated Fgf8 -deficient mice (T-Cre; Fgf8 flox/ Δ 2, 3 mice), which lack Fgf8 expression in the mesoderm, revealed that the cranial region of the Wolffian duct degenerated prematurely and the cranial mesonephric tubules were missing. As a result...

...Satu Kuure; Xuan Chi; Benson Lu; Frank Costantini Signaling by the Ret receptor tyrosine kinase promotes cell movements in the Wolffian duct that give rise to the first ureteric bud tip, initiating kidney development. Although the ETS transcription factors Etv4 and Etv5 are known to be required...

... developed various abnormalities in their renal and urogenital organs. The kidneys and ureters were hypoplastic and the lower ends of the ureters were ectopic. In addition, the vagina and seminal vesicle, which are derived from the lower part of the Müllerian and Wolffian duct, respectively, were absent...

... that mice homozygous for the deletion die immediately after birth, showing renal agenesis and impaired lung development. These developmental defects were attributed to locally restricted ruptures in the basement membrane of the elongating Wolffian duct and of alveolar sacculi. These data demonstrate...

..., although their histological appearance was similar ( Fig. 2 , Table 3 ). The Wolffian ducts were greatly enlarged, although they had a cuboidal epithelium similar to control females, and they were patent for their whole length. The most marked cytological differences were seen at the ovarian end, where...