... to identify mechanisms that mediate basal tissue folding to form the highly conserved embryonic midbrain-hindbrain boundary. Live imaging revealed Wnt5b as a mediator of anisotropic epithelial cell shape, both apically and basally. In addition, we uncovered a Wnt5b-mediated mechanism for specific regulation...

... , but not Myf5 expression;however, we show that the source of the Wnt signal is intrinsic to the mesoderm. Gain- and loss-of-function experiments indicate that Wnt5b ,which is expressed in the presomitic mesoderm, represents the MyoD -activating cue. Despite Wnt5b expression in the presomitic mesoderm, MyoD...

...Yingzi Yang; Lilia Topol; Heuijung Lee; Jinling Wu Proper longitudinal growth of long bones relies on the regulation of specific spatial patterns of chondrocyte proliferation and differentiation. We have studied the roles of two members of the Wnt family, Wnt5a and Wnt5b in long bone development...