... of Wnt5a in the posterior part of mouse embryos causes a local disruption of hair follicle orientation. The misoriented hair follicle phenotype in Wnt5a overexpressing mice can be rescued by a heterozygous loss of Fzd6 , suggesting Wnt5a is likely to signal through Fzd6. Although the membrane distribution...

... rostral migration of FBM neurons by suppressing chemoattraction towards Wnt5a in r3 and successfully tested this model. First, FBM neurons in Celsr1; Wnt5a double mutant embryos never migrated rostrally, indicating that inappropriate rostral migration in Celsr1 mutants results from Wnt5a -mediated...

... data also suggest that the implantation chamber facilitates embryo rotation and its alignment along the uterine mesometrial-antimesometrial axis. Using WNT5A- and RBPJ-deficient mice that display aberrant folds, we show that embryos trapped in longitudinal folds display misalignment of the embryo...

... show that epithelial WNT5A is crucial for determining fourth ventricle (4V) ChP morphogenesis and size in mouse. Systemic Wnt5a knockout, or forced Wnt5a overexpression beginning at embryonic day 10.5, profoundly reduced ChP size and development. However, Wnt5a expression was enriched in Foxj1...

... return to the basal side. WNT5A, which is secreted by surrounding mesenchymal cells, acts as a guidance cue to orchestrate this epithelial pathfinding behavior, but how this signal is received by epithelial cells is unknown. Here, we have investigated two known WNT5A receptors: ROR2 and RYK. We found...

... commitment within the CPC population during both hPSC differentiation and mouse embryogenesis. Wnt5a, which has been shown to exert an inhibitory influence on Wnt signaling during cardiac development, was dynamically expressed during vascular commitment of hPSC-derived CPCs, and ectopic Wnt5a promoted...

... for embryo implantation. Implantation Receptivity Uterus Blastocyst Embryo Confocal Imaging Surface curvature Wnt5a California Institute for Regenerative Medicine 10.13039/100000900 TG2-01153 UCSF Program for Breakthrough Biomedical Research National Institutes...

... that Wnt5a acts as a chemoattractant in the emerging limb bud where it contributes to the establishment of cell polarity that is likely to underlie the oriented cell behaviours. * Author for correspondence ( [email protected] ) Competing interests statement 18 5 2010 © 2010...

....,2002 ). Although Shh is required for the maintenance of genital outgrowth, it is not the early initiation signal. * Author for correspondence (e-mail: [email protected] ) 27 5 2009 © 2009. 2009 Evolution Fgf8 Genitalia Wnt5a Cloaca In the vertebrate limb bud, fibroblast...

... that Wnt5a and its receptor Ror2 are expressed in a graded manner along the AP axis of the palate. Wnt5a deficiency leads to a complete cleft of the secondary palate, which exhibits distinct phenotypic alterations at histological, cellular and molecular levels in the anterior and posterior regions...

... the canonical and non-canonical signaling that are required for the correct establishment of the axes of the Xenopus embryo. We find that the target Wnts of Dkk activity are maternal Wnt5a and Wnt11, and that both Wnts are essential for canonical and non-canonical signaling. We determine that Wnt5a and Wnt11...

...Maria Loscertales; Amanda J. Mikels; Jimmy Kuang-Hsein Hu; Patricia K. Donahoe; Drucilla J. Roberts Wnt5a is an important factor patterning many aspects of early development,including the lung. We find pulmonary non-canonical Wnt5a uses Ror2 to control patterning of both distal air and vascular...

... the expression of a non-canonical signaling member of the wingless-related protein family, Wnt5a. Loss of Wnt5a expression has been associated with poor prognosis in breast cancer patients; however, data are lacking with regard to a functional role for Wnt5a in mammary gland development. We show that Wnt5a...

... urethral epithelium (DUE), distal epithelia marked by the Fgf8 expression, may control the initial GT outgrowth. Exogenously applied BMP4 downregulated the expression of Fgf8 and Wnt5a ,concomitant with increased apoptosis and decreased cell proliferation of the GT mesenchyme. Furthermore, noggin mutants...

...Yingzi Yang; Lilia Topol; Heuijung Lee; Jinling Wu Proper longitudinal growth of long bones relies on the regulation of specific spatial patterns of chondrocyte proliferation and differentiation. We have studied the roles of two members of the Wnt family, Wnt5a and Wnt5b in long bone development...

...Terry P. Yamaguchi; Allan Bradley; Andrew P. McMahon; Steven Jones ABSTRACT Morphogenesis depends on the precise control of basic cellular processes such as cell proliferation and differentiation. Wnt5a may regulate these processes since it is expressed in a gradient at the caudal end...