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Keywords: Wnt5a
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Journal Articles
Journal: Development
Development dev.192054.
Published: 26 April 2021
... epithelial WNT5A is critical for determining fourth ventricle (4V) ChP morphogenesis and size. Systemic Wnt5a knockout, or forced Wnt5a overexpression beginning at E10.5, profoundly reduced ChP size and development. However, Wnt5a expression was enriched in Foxj1 -positive epithelial cells of 4V ChP plexus...
Journal Articles
Journal: Development
Development (2020) 147 (20): dev195388.
Published: 27 October 2020
... return to the basal side. WNT5A, which is secreted by surrounding mesenchymal cells, acts as a guidance cue to orchestrate this epithelial pathfinding behavior, but how this signal is received by epithelial cells is unknown. Here, we have investigated two known WNT5A receptors: ROR2 and RYK. We found...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (1): dev159905.
Published: 08 January 2018
... commitment within the CPC population during both hPSC differentiation and mouse embryogenesis. Wnt5a, which has been shown to exert an inhibitory influence on Wnt signaling during cardiac development, was dynamically expressed during vascular commitment of hPSC-derived CPCs, and ectopic Wnt5a promoted...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2016) 143 (24): 4749–4754.
Published: 15 December 2016
... axis. The fourth measurement point is placed at the starting position that creates a right-angled triangle that dictates the degree to which the glandular duct is bending, with the luminal epithelium always being the standard comparison point. We thank S. K. Dey and Jeeyeon Cha for the Wnt5a...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (15): 2551–2558.
Published: 01 August 2010
... evidence that Wnt5a acts as a chemoattractant in the emerging limb bud where it contributes to the establishment of cell polarity that is likely to underlie the oriented cell behaviours. * Author for correspondence ( sevan.hopyan@sickkids.ca ) Competing interests statement 18 5 2010...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (15): 2643–2651.
Published: 01 August 2009
.... 2009 Evolution Fgf8 Genitalia Wnt5a Cloaca The genital tubercle is the developmental precursor to the male and female external genitalia. Its outgrowth and patterning have been likened to the vertebrate limb bud, but unlike the limb, the genital tubercle is composed of cells from all...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (23): 3871–3879.
Published: 01 December 2008
... Wnt5a and its receptor Ror2 are expressed in a graded manner along the AP axis of the palate. Wnt5a deficiency leads to a complete cleft of the secondary palate, which exhibits distinct phenotypic alterations at histological, cellular and molecular levels in the anterior and posterior regions of the...
Journal Articles
Journal: Development
Development (2008) 135 (22): 3719–3729.
Published: 15 November 2008
... canonical and non-canonical signaling that are required for the correct establishment of the axes of the Xenopus embryo. We find that the target Wnts of Dkk activity are maternal Wnt5a and Wnt11, and that both Wnts are essential for canonical and non-canonical signaling. We determine that Wnt5a and Wnt11...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (7): 1365–1376.
Published: 01 April 2008
...Maria Loscertales; Amanda J. Mikels; Jimmy Kuang-Hsein Hu; Patricia K. Donahoe; Drucilla J. Roberts Wnt5a is an important factor patterning many aspects of early development,including the lung. We find pulmonary non-canonical Wnt5a uses Ror2 to control patterning of both distal air and vascular...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (21): 3929–3939.
Published: 01 November 2007
... the expression of a non-canonical signaling member of the wingless-related protein family, Wnt5a. Loss of Wnt5a expression has been associated with poor prognosis in breast cancer patients; however, data are lacking with regard to a functional role for Wnt5a in mammary gland development. We show that...
Journal Articles
Journal: Development
Development (2003) 130 (25): 6209–6220.
Published: 22 December 2003
... urethral epithelium (DUE), distal epithelia marked by the Fgf8 expression, may control the initial GT outgrowth. Exogenously applied BMP4 downregulated the expression of Fgf8 and Wnt5a ,concomitant with increased apoptosis and decreased cell proliferation of the GT mesenchyme. Furthermore, noggin mutants...
Journal Articles
Journal: Development
Development (2003) 130 (5): 1003–1015.
Published: 01 March 2003
...Yingzi Yang; Lilia Topol; Heuijung Lee; Jinling Wu Proper longitudinal growth of long bones relies on the regulation of specific spatial patterns of chondrocyte proliferation and differentiation. We have studied the roles of two members of the Wnt family, Wnt5a and Wnt5b in long bone development...