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Keywords: Wnt11
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Journal Articles
Journal: Development
Development (2012) 139 (5): 1023–1033.
Published: 01 March 2012
...@mail.med.upenn.edu ) Competing interests statement The authors declare no competing financial interests. 22 12 2011 © 2012. Zebrafish Muscle specific kinase MuSK Unplugged Wnt11 Dishevelled Rab11 Recycling endosome Neuromuscular junction Planar cell polarity...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (6): 1161–1172.
Published: 15 March 2011
... previously reported for loss of Wnt11. In cell culture, Fz4 and Fz8 can mediate noncanonical signaling stimulated by Wnt11, but only Fz4 mediates Wnt11-stimulated canonical signaling. In genetically mosaic mouse ureteric buds, competition between phenotypically mutant Fz4 −/− or Fz4 −/− ;Fz8 −/− cells and...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (24): 4083–4088.
Published: 15 December 2009
... Crescent (Cres), which are members of the sFRP family, have the ability to regulate the diffusibility and signalling areas of the Wnt ligands Wnt8 and Wnt11. We found, using the Xenopus embryo, that Wnts do not diffuse effectively, whereas Frzb and Cres spread very widely. Interestingly, Frzb and Cres...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (22): 3719–3729.
Published: 15 November 2008
... canonical and non-canonical signaling that are required for the correct establishment of the axes of the Xenopus embryo. We find that the target Wnts of Dkk activity are maternal Wnt5a and Wnt11, and that both Wnts are essential for canonical and non-canonical signaling. We determine that Wnt5a and Wnt11...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (3): 503–513.
Published: 01 February 2007
... that axin levels are also regulated by Wnt11 and LRP6. In the oocyte,Wnt11 and/or LRP6 regulates axin to maintain β-catenin at a low level,while in the embryo, asymmetrical Wnt11/LRP6 signaling stabilizesβ-catenin and enriches it on the dorsal side. This suggests that canonical Wnt signaling may not...
Journal Articles
Journal: Development
Development (2006) 133 (15): 2897–2904.
Published: 01 August 2006
... mesoderm. To study the regulation of Wnt6 expression, we have interfered with neighboring signaling pathways. We show that Wnt1 and Wnt3a signaling from the neural tube inhibit Wnt6 expression in the medial surface ectoderm via dermomyotomal Wnt11. We demonstrate that Wnt11 is an epithelialization factor...
Journal Articles
Journal: Development
Development (2005) 132 (11): 2587–2597.
Published: 01 June 2005
... show that Wnt11 is expressed in tissue adjacent to neural crest cells expressing the Wnt receptor Frizzled7 ( Fz7 ). Furthermore, loss- and gain-of-function experiments reveal that Wnt11 plays an essential role in neural crest migration. Inhibition of neural crest migration by blocking Wnt11 activity...
Journal Articles
Journal: Development
Development (2004) 131 (14): 3345–3356.
Published: 15 July 2004
... branching. The experimentally induced dysmorphology associated with deregulated expression of Wnt11 , Gdnf and Fgf7 genes in the early stages of organogenesis indicated a crucial role for sprouty function in coordination of epithelial-mesenchymal and stromal signalling, the sites of expression of these...
Journal Articles
Journal: Development
Development (2003) 130 (14): 3175–3185.
Published: 15 July 2003
... Wolffian duct derived ureteric bud is integral in the generation of ureteric tips and the elaboration of the collecting duct system. Wnt11, a member of the Wnt superfamily of secreted glycoproteins, which have important regulatory functions during vertebrate embryonic development, is specifically expressed...
Journal Articles
Journal: Development
Development (2002) 129 (20): 4763–4772.
Published: 15 October 2002
... specification of dermal progenitors from the medial dermomyotome. This comprises two distinct domains: the dorsomedial lip and a more central region (or intervening zone) that derives from it. We confirm that Wnt1 induces Wnt11 expression in the dorsomedial lip as previously shown, and show using DiI injections...