... and differentiate in a rostral to caudal progression. Tissue grafting experiments have implicated cell signalling by the mesencephalicmetencephalic (mid-hindbrain) junction (or isthmus) in orchestrating these events. We have explored the role of Wnt-1 and FGF8 signalling in the regulation of mesencephalic polarity...

... structures, composed of both host and grafted cells, are reconstructed in this ectopic location at the expense of the host diencephalon. Previous experiments indicated that the induction of En-2 was correlated with Wnt-1 expression within the graft. The aim of the present study was: (i) to determine whether...

.... In the present study, we compared this E-cadherin expression with that of Wnt-1 , which occurs in specific zones in the embryonic brain, and found certain spatiotemporal relations between them: Wnt-1 expression tended to run parallel or overlap with peripheries of the E-cadherin-positive areas. For example...

.... To evaluate the functional significance of the sequence conservation between wingless and Wnt-1, we have examined the effects of expressing the Drosophila gene in mouse mammary epithelial cell lines, wingless induced morphological transformation, focus formation, and mitogenesis in confluent cultures...

... with the graft ( Martinez et al., 1991 ). In this paper we investigate the possibility of Wnt-1 being one of the factors involved in En-2 induction. Since Wnt-1 and En-2 expression patterns have been described as diverging during development of the met-mesencephalic region, we first compared Wnt-1 and En-2...

...Arthur Chakrabarti; Glenn Matthews; Alan Colman; Leslie Dale Like its vertebrate homologues, Xenopus wnt-8 and murine wnt-1, we find that Drosophila wingless (wg) protein causes axis duplication when overexpressed in embryos of Xenopus laevis after mRNA injection. In many cases, the secondary axes...

... signals are required to generate pattern in this tissue. We have isolated a Xenopus cDNA for a Wnt-1 related gene, designated Xwnt-8 , which is activated in ‘response to mesoderm-inducing growth factors. Xwnt-8 transcripts are transiently expressed, being most abundant during gastrulation at which time...