... proteins. Although much focus has been on understanding intracellular Wnt signal transduction, the cellular machinery responsible for Wnt secretion became better understood only recently. After lipid modification by the acyl-transferase Porcupine, Wnt proteins bind their dedicated cargo protein Evi/Wntless...

...Paula Murphy; Chris Armit; Bill Hill; Shanmugasundaram Venkataraman; Patrick Frankel; Richard A. Baldock; Duncan R. Davidson ABSTRACT Wnt signalling controls patterning and differentiation across many tissues and organs of the developing embryo through temporally and spatially restricted expression...

.... Summary: SNARE-dependent secondary secretion via Rab4 recycling endosomes plays an important role in coordinating long-range extracellular levels of the hydrophobic morphogen Wnt/Wingless. Wnt secretion Wnt signalling Endosomal sorting Morphogen trafficking Cell behaviour and growth...

... cortex in a Wnt signalling-dependent manner, leading to the orientation of the SMDD/AIY mother along the anteroposterior axis. Later, during division, APR-1 is still enriched at the anterior cortex, regulating the orientation of the division and the asymmetry of daughter cell fate. After apr-1...

... of Biologists Ltd 2019 Summary: This Review describes the trafficking mechanisms proposed to mediate the extracellular transport of Wnt proteins and discusses how they contribute to Wnt dispersal. Cytoneme Exosome Secretion Signal transduction Wnt signalling Wnt trafficking The Wnt...

... for the morphogenesis of the head and brain. The loss of function of the Wnt inhibitor Dkk1 results in elevated Wnt activity, loss of ectoderm lineage attributes from the anterior epiblast, and the posteriorisation of anterior germ layer tissue towards the mesendoderm. The modulation of Wnt signalling may therefore...

.... M. , Patel , B. B. , Bahrami-Nejad , Z. , Travaglini , K. J. , et al. ( 2016 ). Comparative genetic screens in human cells reveal new regulatory mechanisms in WNT signaling . Elife   5 , 410 . 10.7554/eLife.21459 Lickert , H. , Kispert , A. , Kutsch , S...

.... Published by The Company of Biologists Ltd 2016 Summary: The sequential addition of posterior segments in the spider is controlled by Delta/Notch-mediated regulation of Wnt signalling, and by a downstream gene regulatory network, including pair-rule genes. Segmentation Spiders Wnt signalling...

... to target genomic loci serves as the hallmark of canonical Wnt signalling, mechanisms controlling stage- or tissue-specific transcriptional responses remain elusive. Here, a direct comparison of genome-wide occupancy of β-catenin with a stage-matched Wnt-regulated transcriptome reveals that only a subset...

... that accompanies the formation of the anterior mesendoderm, in part through regulation of Pcdh7 expression. LHX1 also regulates, in the anterior mesendoderm, the transcription of genes encoding negative regulators of WNT signalling, such as Dkk1 , Hesx1 , Cer1 and Gsc. Embryos carrying mutations in Pcdh7...

...Monica Nagendran; Prateek Arora; Payal Gori; Aditya Mulay; Shinjini Ray; Tressa Jacob; Mahendra Sonawane The patterning and morphogenesis of body appendages – such as limbs and fins – is orchestrated by the activities of several developmental pathways. Wnt signalling is essential for the induction...

... differentiation by promoting Wnt/β-catenin signalling in the developing forebrain. In addition, we show that Fezf2 promotes activation of Wnt/β-catenin signalling by repressing the expression of two negative regulators of Wnt signalling, namely lhx2 and lhx9 . Our findings suggest that Fezf2 plays an essential...

..., an agonist of Wnt signalling, has revealed the emergence of a small population of cells that co-expresses markers of the primitive streak and Sox2, a blueprint of the NMp ( Tsakiridis et al., 2014 ). Here, we extend these observations to mouse ESCs (mESCs) and show that modulation of Wnt signalling during...

... EpiSCs are biased towards mesoderm and endoderm fates while retaining pluripotency. The acquisition of primitive streak characteristics by self-renewing EpiSCs is mediated by endogenous Wnt signalling. Elevation of Wnt activity promotes restriction towards primitive streak-associated lineages...

...Natalie Gibb; Danielle L. Lavery; Stefan Hoppler Wnt signalling is a key regulator of vertebrate heart development, yet it is unclear which specific Wnt signalling components are required to regulate which aspect of cardiogenesis. Previously, we identified Wnt6 as an endogenous Wnt ligand required...

... crypt axis with the highest levels at the crypt bottom. In addition, colorectal cancers show a heterogeneous subcellular pattern of β-catenin accumulation. However, it remains unclear whether different levels of Wnt signalling exert distinct roles in the colonic epithelium. Here, we investigated...

... by which the PLLP normally ends its migration, suggesting that suppression of Wnt signalling is required for termination of neuromast production in the tail. Our data support a model in which Lef1 sustains proliferation of leading zone progenitors, maintaining the primordium size and defining neuromast...

..., Parc Valrose, 06108 Nice cedex 2, France Competing interests statement The authors declare no competing financial interests. 27 5 2011 © 2011. Wnt signalling Liver Swim bladder Endoderm patterning Organogenesis Zebrafish A central focus...

...Anke Beermann; Romy Prühs; Rebekka Lutz; Reinhard Schröder Short germ embryos elongate their primary body axis by consecutively adding segments from a posteriorly located growth zone. Wnt signalling is required for axis elongation in short germ arthropods, including Tribolium castaneum...

...Nicolas Fossat; Vanessa Jones; Poh-Lynn Khoo; Debora Bogani; Andrea Hardy; Kirsten Steiner; Mahua Mukhopadhyay; Heiner Westphal; Patrick M. Nolan; Ruth Arkell; Patrick P. L. Tam In mouse embryos, loss of Dickkopf-1 (DKK1) activity is associated with an ectopic activation of WNT signalling responses...