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Keywords: Wnt signaling
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Journal Articles
Journal: Development
Development (2022) 149 (9): dev200340.
Published: 12 May 2022
... extracellular signaling pathways interact to control the development of a morphologically complex structure ( Zuniga, 2015 ). Among these pathways, WNT signaling plays multiple roles in limb development. In the developing mouse limb between embryonic day (E)9.5 and E15.5, 15/19 WNTs and 10/13 extracellular WNT...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (14): dev199685.
Published: 22 July 2021
... pathway have shown that tooth formation is partly inhibited in loss-of-function mutants, and gain-of-function mutants have perturbed tooth morphology. However, the stage at which Wnt signaling is first important in tooth formation remains unclear. Here, using an Fgf8 -promoter-driven, and therefore early...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (11): dev199408.
Published: 1 June 2021
... for in vivo Hox13-binding sites in the zebrafish tailbud reveals a highly conserved enhancer element necessary for NMp expression of brachyury and body axis elongation . Hox genes Brachyury Wnt signaling Neuromesodermal progenitors All vertebrate embryos form their anterior-posterior...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2021) 148 (9): dev198846.
Published: 29 April 2021
... for reproduction, but how this is achieved is unclear. Here, we show that canonical wingless-type MMTV integration site family (WNT) signaling is pivotal for pre-granulosa cell (pre-GC) activation during PFA. We identified several WNT ligands expressed in pre-GCs that act in an autocrine manner. Inhibition of WNT...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (7): dev191197.
Published: 31 March 2021
... , D. R. ( 2006 ). RhoA regulates initiation of invagination, but not convergent extension, during sea urchin gastrulation . Dev. Biol. 292 , 213 - 225 . 10.1016/j.ydbio.2005.12.031 Bince , J. M. and Wikramanayake , A. H. ( 2008 ). Functional analysis of Wnt signaling...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (2): dev184341.
Published: 19 January 2021
... signaling and Snai1 stability. DDX3 Neural crest (NC) AKT GSK3β Wnt signaling Xenopus Neural crest (NC) cells are multipotent stem cells that are induced to form at the neural plate border (the border of neural plate and epidermis; NPB) during vertebrate gastrulation. After...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (1): dev196048.
Published: 11 January 2021
.... Androgen signaling Prostate development Wnt signaling Sonic hedgehog signaling Mouse models Summary: Using newly generated mouse genetic tools, we demonstrate the dynamic regulation of mesenchymal androgen signaling as cellular niches controlling prostate early development. © 2021...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (22): dev185298.
Published: 27 November 2020
... act within the NMps to enhance the niche-promoting effects of Brachyury. The regulation of Wnt signaling in the tailbud is challenging for the embryo. In the NMps, Wnt signaling needs to be regulated at a level high enough for Brachyury expression to be maintained, but not so high as to force...
Includes: Supplementary data
Journal Articles
In collection:
Human development
Journal: Development
Development (2020) 147 (22): dev192518.
Published: 19 November 2020
..., and live cell imaging reveals aberrant recycling of the WNT ligand-binding protein WLS and mis-trafficking to the lysosome for degradation. The importance of SNX3 in WNT signaling regulation is demonstrated by rescue of NT closure in Snx3 −/− embryos with a WNT agonist. The potential for SNX3 to function...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (17): dev185678.
Published: 2 September 2020
.... Deficiency of epithelial Erk1/2 results in defects in secretory cell differentiation as well as impaired mesenchymal cell proliferation and maturation. Deletion of Erk1/2 strongly activated Wnt signaling through both cell-autonomous and non-autonomous mechanisms. In epithelial cells, Erk1/2 depletion...
Includes: Supplementary data
Journal Articles
In collection:
Human development
Journal: Development
Development (2020) 147 (12): dev189977.
Published: 22 June 2020
.... β cell differentiation Retinoic acid signaling Wnt signaling Pancreas development Diabetes δ cell specification Cell signaling pathways are used continuously throughout development and adulthood to mediate tissue interactions and precisely control gene expression. In particular...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (22): dev180034.
Published: 18 November 2019
... to proliferative cell division, the C. elegans RNT-1/BRO-1 transcriptional repressor opposes POP-1 TCF expression in seam stem cells, which turns POP-1-induced differentiation into self-renewal. C. elegans Wnt signaling Runx Asymmetric cell division Stem cell division mode Transcriptional regulation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (20): dev179093.
Published: 17 October 2019
...George Britton; Idse Heemskerk; Rachel Hodge; Amina A. Qutub; Aryeh Warmflash ABSTRACT During development, the ectoderm is patterned by a combination of BMP and WNT signaling. Research in model organisms has provided substantial insight into this process; however, there are currently no systems...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (15): dev179580.
Published: 9 August 2019
... with ring patterns. Manipulation of FGF or Wnt signaling demonstrated that ‘ring’ genes are responsive to FGF signaling at the dorsal midline, whereas ‘horseshoe’ genes are predominantly regulated by Wnt signaling. We suggest that, in the absence of active β-catenin at the dorsal midline, the DNA-binding...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (13): dev164145.
Published: 2 July 2019
... interactions that prevent β-catenin degradation. Surprisingly, the nucleus is surrounded by active DCs, which principally control the degradation of β-catenin and thereby nuclear access. These DCs are inactivated and removed upon Wnt signal transduction. These results suggest a novel mechanistic model...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2018) 145 (24): dev168666.
Published: 17 December 2018
... controls neuronal migration in metazoans, in addition to many other aspects of neural development. We show that Caenorhabditis elegans VANG-1, a membrane protein that acts in the planar cell polarity (PCP) pathway, antagonizes Wnt signaling by facilitating endocytosis of the Frizzled receptors. Mutations...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (23): dev171827.
Published: 26 November 2018
... canonical WNT signaling. Loss of TBX2/TBX3 in this region disrupts activity of two crucial drivers of the SMC program, Foxf1 and BMP4 signaling, resulting in decreased SMC differentiation and increased extracellular matrix. Transcriptional profiling and chromatin immunoprecipitation experiments revealed...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (21): dev162388.
Published: 29 October 2018
... profiling of the regenerating feather blastema revealed that Wnt signaling is among the most active pathways during feather regeneration, with Wnt ligands and their inhibitors showing distinct expression patterns. Co-expression analysis identified hundreds of lncRNAs with similar expression patterns...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (17): dev162792.
Published: 14 September 2018
...Jianqiong Lin; Zhicao Yue ABSTRACT Sensing a global directional cue to orient cell growth is crucial in tissue morphogenesis. An anterior-posterior gradient of Wnt signaling controls the helical growth of feather branches (barbs), and thus the formation of bilateral feathers. However, it remains...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (12): dev154898.
Published: 14 June 2018
..., respectively. Summary: A model for developmentally scheduled regression of vascular endothelial cells reveals a link between the Wnt/β-catenin pathway and the cell-cycle regulators MYC and CDKN1A. Hyaloid Vascular regression Wnt signaling MYC CDKN1A P21 Endothelial cell Much...
Includes: Supplementary data