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Keywords: Wnt signaling
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Journal Articles
Journal: Development
Development (2021) 148 (11): dev199408.
Published: 01 June 2021
... . Hox genes Brachyury Wnt signaling Neuromesodermal progenitors All vertebrate embryos form their anterior-posterior axis by adding cells progressively to the posterior end of the presomitic mesoderm and spinal cord from a neuromesodermal progenitor population (NMp) located in the tailbud...
Includes: Supplementary data
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Reproductive biology
Journal: Development
Development (2021) 148 (9): dev198846.
Published: 29 April 2021
... reproduction, but how this is achieved is unclear. Here, we show that canonical wingless-type MMTV integration site family (WNT) signaling is pivotal for pre-granulosa cell (pre-GC) activation during PFA. We identified several WNT ligands expressed in pre-GCs that act in an autocrine manner. Inhibition of WNT...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (7): dev191197.
Published: 31 March 2021
... cell fates in multipotent early blastomeres, and to ensure correct anterior-posterior axis patterning. Wnt signaling Axin Sea urchin Anterior-posterior axis Animal-vegetal axis Endomesoderm During embryonic development in most bilaterally symmetrical animals (Bilateria), the...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (2): dev184341.
Published: 19 January 2021
... The Company of Biologists Ltd 2021 Summary: To model human birth defects caused by DDX3X mutations, we show that Xenopus DDX3 induces neural crest via the AKT-GSK3β axis, which promotes Wnt signaling and Snai1 stability. DDX3 Neural crest (NC) AKT GSK3β Wnt signaling Xenopus...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (1): dev196048.
Published: 11 January 2021
... cellular niches controlling prostate early development. Androgen signaling Prostate development Wnt signaling Sonic hedgehog signaling Mouse models The prostate develops from the endodermal urogenital sinus (UGS) that is derived from the caudal terminus of the hindgut called the cloaca...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (22): dev185298.
Published: 27 November 2020
.../user-licence-1-1/ Highlighted Article: The Hox13 genes are shown to have a novel crucial role in ensuring development of the posterior body in zebrafish through sustaining the tailbud-derived bipotential neuromesodermal progenitors. Hox genes Brachyury Wnt signaling Neuromesodermal...
Includes: Supplementary data
Journal Articles
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Human development
Journal: Development
Development (2020) 147 (22): dev192518.
Published: 19 November 2020
..., and live cell imaging reveals aberrant recycling of the WNT ligand-binding protein WLS and mis-trafficking to the lysosome for degradation. The importance of SNX3 in WNT signaling regulation is demonstrated by rescue of NT closure in Snx3 −/− embryos with a WNT agonist. The potential for SNX3 to...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (17): dev185678.
Published: 02 September 2020
.... Deficiency of epithelial Erk1/2 results in defects in secretory cell differentiation as well as impaired mesenchymal cell proliferation and maturation. Deletion of Erk1/2 strongly activated Wnt signaling through both cell-autonomous and non-autonomous mechanisms. In epithelial cells, Erk1/2 depletion...
Includes: Supplementary data
Journal Articles
In collection:
Human development
Journal: Development
Development (2020) 147 (12): dev189977.
Published: 22 June 2020
... lineage affects the development of hormone-producing cells, we completed a gene ontology (GO) term analysis ( Mi et al., 2019 ) of significantly changed genes at E16.5. These GO terms revealed that Wnt signaling components were significantly affected by the inhibition of RA ( Fig. 4 D), including nine Wnt...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (22): dev180034.
Published: 18 November 2019
...-related transcriptional repression. Summary: To switch asymmetric to proliferative cell division, the C. elegans RNT-1/BRO-1 transcriptional repressor opposes POP-1 TCF expression in seam stem cells, which turns POP-1-induced differentiation into self-renewal. C. elegans Wnt signaling...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (20): dev179093.
Published: 17 October 2019
...George Britton; Idse Heemskerk; Rachel Hodge; Amina A. Qutub; Aryeh Warmflash ABSTRACT During development, the ectoderm is patterned by a combination of BMP and WNT signaling. Research in model organisms has provided substantial insight into this process; however, there are currently no systems in...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (15): dev179580.
Published: 09 August 2019
... with ring patterns. Manipulation of FGF or Wnt signaling demonstrated that ‘ring’ genes are responsive to FGF signaling at the dorsal midline, whereas ‘horseshoe’ genes are predominantly regulated by Wnt signaling. We suggest that, in the absence of active β-catenin at the dorsal midline, the DNA...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (13): dev164145.
Published: 02 July 2019
... interactions that prevent β-catenin degradation. Surprisingly, the nucleus is surrounded by active DCs, which principally control the degradation of β-catenin and thereby nuclear access. These DCs are inactivated and removed upon Wnt signal transduction. These results suggest a novel mechanistic model for...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (24): dev168666.
Published: 17 December 2018
... controls neuronal migration in metazoans, in addition to many other aspects of neural development. We show that Caenorhabditis elegans VANG-1, a membrane protein that acts in the planar cell polarity (PCP) pathway, antagonizes Wnt signaling by facilitating endocytosis of the Frizzled receptors. Mutations...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (23): dev171827.
Published: 26 November 2018
... canonical WNT signaling. Loss of TBX2/TBX3 in this region disrupts activity of two crucial drivers of the SMC program, Foxf1 and BMP4 signaling, resulting in decreased SMC differentiation and increased extracellular matrix. Transcriptional profiling and chromatin immunoprecipitation experiments revealed...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (21): dev162388.
Published: 29 October 2018
... profiling of the regenerating feather blastema revealed that Wnt signaling is among the most active pathways during feather regeneration, with Wnt ligands and their inhibitors showing distinct expression patterns. Co-expression analysis identified hundreds of lncRNAs with similar expression patterns to...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (17): dev162792.
Published: 14 September 2018
...Jianqiong Lin; Zhicao Yue ABSTRACT Sensing a global directional cue to orient cell growth is crucial in tissue morphogenesis. An anterior-posterior gradient of Wnt signaling controls the helical growth of feather branches (barbs), and thus the formation of bilateral feathers. However, it remains...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (12): dev154898.
Published: 14 June 2018
... endothelial cells reveals a link between the Wnt/β-catenin pathway and the cell-cycle regulators MYC and CDKN1A. Hyaloid Vascular regression Wnt signaling MYC CDKN1A P21 Endothelial cell Much progress has been made in our understanding of the mechanisms that regulate development of the...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (11): dev146589.
Published: 08 June 2018
... or financial interests. © 2018. Published by The Company of Biologists Ltd 2018 Summary: An overview of Wnt-β-catenin signaling highlighting its key functions during development and adult tissue homeostasis. Wnt protein Wnt signaling Epigenetics Wnt proteins are secreted...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (7): dev143107.
Published: 10 April 2018
...Hyeyoon Lee; Seong-Moon Cheong; Wonhee Han; Youngmu Koo; Saet-Byeol Jo; Gun-Sik Cho; Jae-Seong Yang; Sanguk Kim; Jin-Kwan Han ABSTRACT Dishevelled (Dvl/Dsh) is a key scaffold protein that propagates Wnt signaling essential for embryogenesis and homeostasis. However, whether the antagonism of Wnt...
Includes: Supplementary data