... and disorganized chondrocytes due to impaired cellular orientation and polarity. We show that these proteins regulate cartilage differentiation by controlling the timing of Wnt/β-catenin activity in strikingly different ways: Prdm3 represses whereas Prdm16 activates global gene expression, although both act...

.... By contrast, the neonatal heart retains a transient regenerative capacity, but the underlying mechanisms for the developmental loss of cardiac regenerative capacity in mammals are not fully understood. Wnt/β-catenin signalling has been proposed as a key cardioregenerative pathway driving cardiomyocyte...

... columnar cells; noteworthy, zebrafish stat3 mutants show defects in intestinal folding. Stat3 reporter activity in the gut is abolished with mutation of T cell factor 4 (Tcf7l2), the intestinal mediator of Wnt/β-catenin-dependent transcription. The Wnt/β-catenin dependence of Stat3 activity in the gut...

... 18 1 2019 © 2019. Published by The Company of Biologists Ltd 2019 http://www.biologists.com/user-licence-1-1/ Summary: Wnt proteins from the epithelium control the formation of mouse airway cartilage and basal cells through crosstalk with Fgf signaling. Fgf Wnt/β-catenin...

... side of the first tooth from the successional dental lamina. This lamina expresses the stem/progenitor marker Sox2 and has activated Wnt/β-catenin signalling at its tip. Although the mouse does not replace its teeth, a transient rudimentary successional dental lamina (RSDL) still forms during...

... perturbing epithelial Wnt/β-catenin signaling. In addition, loss-of-function mutations in the Wnt feedback inhibitor AXIN2 lead to human tooth agenesis. We have investigated the functions of Wnt/β-catenin signaling during sequential formation of molar teeth using mouse models. Continuous initiation of new...

... mechanisms governing taste cell formation and turnover. Taste buds Gustatory system Sonic hedgehog Wnt/β-catenin Cell lineage Molecular genetics Taste dysfunction Dysgeusia Ageusia Chemotherapy Stem cells Lingual organoids Gustation, or the sense of taste, allows us to distinguish...

...-extension (CE) cell movements, neural crest migration and neural tube closure in vertebrate embryos. Besides CE phenotypes, we now show that PTK7 protein knockdown also inhibits Wnt/β-catenin activity. Canonical Wnt signaling caudalizes the neural plate via direct transcriptional activation of the meis3...

... show that β-catenin controls ventricular myocyte proliferation during development and the perinatal period. We further demonstrate that the differential activation of the Wnt/β-catenin signaling pathway accounts for the observed differences in the proliferation rates of the compact versus...

...Cynthia L. Andoniadou; Massimo Signore; Rodrigo M. Young; Carles Gaston-Massuet; Stephen W. Wilson; Elaine Fuchs; Juan Pedro Martinez-Barbera The Wnt/β-catenin pathway plays an essential role during regionalisation of the vertebrate neural plate and its inhibition in the most anterior neural...

...) to a lesser extent, with virtually no contribution to intrinsic and extrinsic tongue muscles or extraocular muscles. In addition,in vivo activation of the Wnt/β-catenin pathway in chick embryos resulted in marked inhibition of Isl1, whereas inhibition of this pathway increased Isl1 expression. Our findings...

...Mahua Mukhopadhyay; Marat Gorivodsky; Svetlana Shtrom; Alexander Grinberg; Christoph Niehrs; Maria I. Morasso; Heiner Westphal The Dkk family of secreted cysteine-rich proteins regulates Wnt/β-catenin signaling by interacting with the Wnt co-receptor Lrp5/6. Here, we show that Dkk2-mediated...

...Rolf Kemler; Andreas Hierholzer; Benoît Kanzler; Stefan Kuppig; Kati Hansen; Makoto M. Taketo; Wilhelmine N. de Vries; Barbara B. Knowles; Davor Solter Many components of the Wnt/β-catenin signaling pathway are expressed during mouse pre-implantation embryo development, suggesting...

...Jing Yang; Jinling Wu; Change Tan; Peter S. Klein The Wnt/β-catenin pathway plays important roles during embryonic development and growth control. The B56 regulatory subunit of protein phosphatase 2A (PP2A) has been implicated as a regulator of this pathway. However, this has not been investigated...