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Keywords: Wnt
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Journal Articles
Journal: Development
Development (2021) 148 (9): dev194597.
Published: 29 April 2021
... required for the progression of tooth development. IK cell dynamics demonstrate the hallmarks of a signaling center: cell cycle exit, condensation and eventual silencing through apoptosis. IK initiation and maturation are defined by the juxtaposition of cells with high Wnt activity to Shh -expressing non...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (22): dev190173.
Published: 30 November 2020
... identified as a master gene in hindbrain choroid plexus patterning and multiciliogenesis. Choroid plexus Patterning Development Hindbrain Wnt BMP Cilium Multiciliated cells Multiciliated epithelium Microvilli Zfp423 ZNF423 Joubert syndrome JS19 Hydrocephalus The choroid plexus...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (19): dev191981.
Published: 05 October 2020
.... Wnt proteins are evolutionarily conserved polarity cues, yet Wnt mutants display variable PCP defects; thus, how Wnts regulate PCP remains unresolved. Here, we have used the developing cochlea as a model system to show that secreted Wnts regulate PCP through polarizing a specific subset of PCP...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (18): dev188839.
Published: 15 September 2020
... give rise to zymogenic cells in culture. Modulating the activity of the WNT, BMP and Notch pathways in vivo and ex vivo , we found that WNTs are essential for the maintenance of Lgr5 + epithelial cells. Notch prevents differentiation of the embryonic epithelial cells along all secretory lineages and...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (17): dev188094.
Published: 11 September 2020
...Olga Ossipova; Keiji Itoh; Aurelian Radu; Jerome Ezan; Sergei Y. Sokol ABSTRACT Among the three embryonic germ layers, the mesoderm plays a central role in the establishment of the vertebrate body plan. The mesoderm is specified by secreted signaling proteins from the FGF, Nodal, BMP and Wnt...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (14): dev186080.
Published: 23 July 2020
... pathway, that increases Wnt production from motor neurons. We also provide evidence that this neuronal Wnt contributes to EGL-30-stimulated vulval development, with muscle producing a parallel developmental signal. As diverse sensory modalities stimulate motor neurons via acetylcholine, this mechanism...
Includes: Supplementary data
Journal Articles
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Reproductive biology
Journal: Development
Development (2020) 147 (6): dev183814.
Published: 30 March 2020
... molecular signals ensure ovary versus testis differentiation with canonical Wnt/β-catenin signals paramount for promoting the ovary pathway. Notably, few direct downstream targets have been identified. We report that Wnt/β-catenin signaling directly stimulates Irx3 and Irx5 transcription in the developing...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (6): dev182865.
Published: 16 March 2020
... excellent model for investigating how signaling control facilitates the generation of defined neuronal populations. Wnt signaling is required for habenular neuron type specification, asymmetry and axonal connectivity. The temporal regulation of this pathway and the players involved have, however, remained...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (22): dev180091.
Published: 14 November 2019
... Article: The asymmetric activity of Bmp signaling within the superior atrioventricular canal is essential for normal looping morphogenesis of the zebrafish heart. BMP Wnt Cardiac looping Hemodynamics Zebrafish The term ‘cardiac looping’ defines a morphogenetic process during vertebrate...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (21): dev183269.
Published: 08 November 2019
... modulates signalling in order to facilitate the differentiation process. Cadherin FGF Neural development Pluripotent Wnt Mouse There is an increasing appreciation that changes in adhesion and morphology help to regulate cell fate changes ( Gilmour et al., 2017 ). The homotypic adhesion...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (20): dev177550.
Published: 10 October 2019
... breast by suppressing mitogenic WNT signaling in mouse. In striking contrast to these systems, we found that co-deleting Gsk3a and Gsk3b blocked CGNP proliferation, causing severe cerebellar hypoplasia. The GSK-3 inhibitor CHIR-98014 similarly downregulated SHH-driven proliferation. Transcriptomic...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (15): dev174789.
Published: 09 August 2019
...Varun Chaudhary; Swapnil Hingole; Jana Frei; Fillip Port; David Strutt; Michael Boutros ABSTRACT Wnts are secreted proteins that regulate cell fate during development of all metazoans. Wnt proteins were proposed to spread over several cells to activate signaling directly at a distance. In the...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (10): dev173112.
Published: 22 May 2019
...Elena Sena; Nathalie Rocques; Caroline Borday; Harem Sabr Muhamad Amin; Karine Parain; David Sitbon; Albert Chesneau; Béatrice C. Durand ABSTRACT A hallmark of Wnt/β-Catenin signaling is the extreme diversity of its transcriptional response, which varies depending on the cell and developmental...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (8): dev168294.
Published: 29 April 2019
..., we show that wnt9a and wnt9b are induced in the injured kidney at sites where frizzled9b - and lef1 -expressing progenitor cells form new nephrons. New nephron aggregates are patterned by Wnt signaling, with high canonical Wnt-signaling cells forming a single cell thick rosette that demarcates...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (6): dev172791.
Published: 25 March 2019
... primitive streak (PS) by WNT. In the pluripotent state, E-cadherin (E-CAD) transduces boundary forces to focus WNT signaling to the colony border. Following application of WNT ligand, E-CAD mediates a front or wave of epithelial-to-mesenchymal (EMT) conversion analogous to PS extension in an embryo. By...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (2): dev159343.
Published: 16 January 2019
... effects of morphological changes on intercellular signaling remain to be fully elucidated. In this study, we examined the effect of morphological changes in Wnt-producing cells on intercellular signaling in the spinal cord. After mid-gestation, roof-plate cells stretched along the dorsoventral axis in the...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (23): dev168716.
Published: 05 December 2018
... investigated the relationship between two signals, Wnt and EGFR, that are necessary for self-renewal of the epithelial follicle stem cells (FSCs) in the Drosophila ovary, but must be downregulated in cells that have exited the niche to allow for differentiation. We found that Wingless produced by inner...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (23): dev166579.
Published: 27 November 2018
... transient capacity for regeneration, and forced Wnt activation in neonatal stages promotes supporting cell (SC) proliferation and induction of ectopic HCs. We currently know little about the temporal pattern and underlying mechanism of this age-dependent regenerative response. Using an in vitro model, we...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (18): dev164897.
Published: 21 September 2018
... neurons, where this pathway activates CEBP-1, we find that RPM-1 and the DLK-1 pathway instead regulate the response to extracellular Wnt cues in developing AVG axons. The Wnt LIN-44 promotes the posterior growth of the AVG axon. In the absence of RPM-1 activity, AVG becomes responsive to a different Wnt...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (8): dev163824.
Published: 13 April 2018
... emerging as a crucial evolutionarily conserved mechanism whereby directional information is conveyed. PCP is thought to be established by global cues, and recent studies have revealed an instructive role of a Wnt signaling gradient in epithelial tissues of both invertebrates and vertebrates. However, it...
Includes: Supplementary data