... controlling their differentiation in health and disease are poorly understood. The winged helix transcription factor, FOXA2, is expressed in the foregut endoderm and in subsets of respiratory epithelial cells in the fetal and adult lung. Because targeted mutagenesis of the Foxa2 gene in mice is lethal before...

... © 1999 by Company of Biologists 1999 Winged helix Epidermis fork head Crystallin Pax6 Xenopus The currently favored model for lens determination in Xenopus includes four stages: competence, bias, specification and differentiation ( Grainger, 1996 ). Competence refers...

...Roland Wehr; Ahmed Mansouri; Tine de Maeyer; Peter Gruss ABSTRACT The murine winged helix gene Fkh5 is specifically expressed in the developing central nervous system (CNS). Early embryonic Fkh5 expression is restricted to the mammillary body region of the caudal hypothalamus, midbrain, hindbrain...

...Klaus H. Kaestner; Susanne C. Bleckmann; A. Paula Monaghan; Johannes Schlöndorff; Antoaneta Mincheva; Peter Lichter; Günther Schütz ABSTRACT The ‘winged helix’ or ‘ forkhead ’ transcription factor gene family is defined by a common 100 amino acid DNA binding domain which is a variant of the helix...