..., France Competing interests statement The authors declare no competing financial interests. 19 7 2013 © 2013. Published by The Company of Biologists Ltd 2013 Drosophila Hippo signaling Tissue growth Tissue mechanics Wing imaginal disc Tissues develop...

...Tinri Aegerter-Wilmsen; Maria B. Heimlicher; Alister C. Smith; Pierre Barbier de Reuille; Richard S. Smith; Christof M. Aegerter; Konrad Basler The regulation of organ size constitutes a major unsolved question in developmental biology. The wing imaginal disc of Drosophila serves as a widely used...

... must be tightly regulated. We have investigated the mechanisms of this regulation in the Drosophila hinge, a domain within the wing imaginal disc that depends on the fly Wnt1 ortholog wingless ( wg ) for its proliferation. Our results uncover a new feedback loop in the wg pathway in which the spatially...

... Notch Wingless EGF receptor Wing imaginal disc Growth and fate specification of a given organ are two regulated processes that have to be tightly coupled to generate a correctly shaped and sized structure ( Lecuit and Le Goff,2007 ). Uncoupling these two processes has disastrous consequences...

...David Nusinow; Lina Greenberg; Victor Hatini Central to embryonic development is the generation of molecular asymmetries across fields of undifferentiated cells. The Drosophila wing imaginal disc provides a powerful system with which to understand how such asymmetries are generated and how...

... in the wing imaginal disc. The binding of the repressor isoform HOW(L) to the dpp 3′ untranslated region (UTR) leads to a reduction of GFP-dpp 3′UTR reporter levels in S-2 cells, in an HRE site-dependent manner. Moreover, co-expression of HOW(L) in the wing imaginal disc with a dpp-GFP fusion construct led...

... Department at Brown University( http://www.calit2.net/~jschulze/ )]. Fluorescence intensity profiles were obtained using Metamorph across the regions of the wing disc shown in each figure. Overexpression of Bmp ligands, Gbb or Dpp, throughout the wing imaginal disc results in a range of wing...

...Myriam Zecca; Gary Struhl Growth and patterning of the Drosophila wing imaginal disc depends on its subdivision into dorsoventral (DV) compartments and limb (wing) and body wall (notum) primordia. We present evidence that both the DV and wing-notum subdivisions are specified by activation...

...Myriam Zecca; Gary Struhl The subdivision of the Drosophila wing imaginal disc into dorsoventral (DV) compartments and limb-body wall (wing-notum) primordia depends on Epidermal Growth Factor Receptor (EGFR) signaling, which heritably activates apterous ( ap ) in D compartment cells and maintains...

.... One such modification is the acylation of the N-terminal cysteine of Hh. In a screen for zygotic lethal mutations associated with maternal effects, we have identified rasp , a novel Drosophila segment polarity gene. Analysis of the rasp mutant phenotype, in both the embryo and wing imaginal disc...

... levels of the Dpp receptor thick veins ( tkv ) are not uniform along the anterior-posterior axis of the wing imaginal disc. Receptor levels are low where Dpp induces its targets Spalt and Omb in the wing pouch. Receptor levels increase in cells farther from the source of Dpp in the lateral regions...

...-cistronic Mrna translation in wing imaginal discs of Drosophila . Applying our test to Ubx , we find that ectopic Ubx in wing discs strictly coincides with β-galactosidase expression. Consequently, wing cells are transformed into cells that appear to be intermediates between wing and haltere cells...

... wing imaginal disc cell lineage compartments apterous LIM domain transcription factor cut homeobox In the developing imaginal discs of Drosophila , a small number of lineage restrictions appear that prevent the mixing of cells in adjacent compartments. These restrictions...