... pathway can be used to assess localization and function of the corresponding proteins. TGF-β/BMP signaling Functionalized protein binder tools Wing imaginal disc Drosophila development Endogenous protein tagging Oogenesis Deutsche Forschungsgemeinschaft http://dx.doi.org/10.13039...

... 2013 Drosophila Hippo signaling Tissue growth Tissue mechanics Wing imaginal disc Developmental mechanics have mostly been investigated in animal tissues that grow poorly, often in the context of gastrulation. Here, we study growing tissues that shape themselves as they grow...

...Tinri Aegerter-Wilmsen; Maria B. Heimlicher; Alister C. Smith; Pierre Barbier de Reuille; Richard S. Smith; Christof M. Aegerter; Konrad Basler The regulation of organ size constitutes a major unsolved question in developmental biology. The wing imaginal disc of Drosophila serves as a widely used...

... must be tightly regulated. We have investigated the mechanisms of this regulation in the Drosophila hinge, a domain within the wing imaginal disc that depends on the fly Wnt1 ortholog wingless ( wg ) for its proliferation. Our results uncover a new feedback loop in the wg pathway in which the spatially...

.... and Pan, D. ( 2003 ). hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts. Cell 114 , 445 -456. Zecca, M. and Struhl, G. ( 2002 ). Subdivision of the Drosophila wing imaginal disc by EGFR-mediated signaling...

...David Nusinow; Lina Greenberg; Victor Hatini Central to embryonic development is the generation of molecular asymmetries across fields of undifferentiated cells. The Drosophila wing imaginal disc provides a powerful system with which to understand how such asymmetries are generated and how...

... in the wing imaginal disc. The binding of the repressor isoform HOW(L) to the dpp 3′ untranslated region (UTR) leads to a reduction of GFP-dpp 3′UTR reporter levels in S-2 cells, in an HRE site-dependent manner. Moreover, co-expression of HOW(L) in the wing imaginal disc with a dpp-GFP fusion construct led...

.... Taken together, these findings suggest that excess Gbb signaling is mediated by endogenous Tkv but antagonized by endogenous Sax. * Author for correspondence (e-mail: [email protected] ) Bmp signaling Dpp Gbb Tkv Sax Bmp type I receptor Wing imaginal disc Morphogen...

...Myriam Zecca; Gary Struhl Growth and patterning of the Drosophila wing imaginal disc depends on its subdivision into dorsoventral (DV) compartments and limb (wing) and body wall (notum) primordia. We present evidence that both the DV and wing-notum subdivisions are specified by activation...

...Myriam Zecca; Gary Struhl The subdivision of the Drosophila wing imaginal disc into dorsoventral (DV) compartments and limb-body wall (wing-notum) primordia depends on Epidermal Growth Factor Receptor (EGFR) signaling, which heritably activates apterous ( ap ) in D compartment cells and maintains...

.... One such modification is the acylation of the N-terminal cysteine of Hh. In a screen for zygotic lethal mutations associated with maternal effects, we have identified rasp , a novel Drosophila segment polarity gene. Analysis of the rasp mutant phenotype, in both the embryo and wing imaginal disc...

... levels of the Dpp receptor thick veins ( tkv ) are not uniform along the anterior-posterior axis of the wing imaginal disc. Receptor levels are low where Dpp induces its targets Spalt and Omb in the wing pouch. Receptor levels increase in cells farther from the source of Dpp in the lateral regions...

...-cistronic Mrna translation in wing imaginal discs of Drosophila . Applying our test to Ubx , we find that ectopic Ubx in wing discs strictly coincides with β-galactosidase expression. Consequently, wing cells are transformed into cells that appear to be intermediates between wing and haltere cells...

... ). Developmental genetics of the venation pattern of Drosophila . Ann. Rev. Genet . 26 , 275 – 302 . 10.1146/annurev.ge.26.120192.001425 Garcia-Bellido , A. and Merriam , J. R. ( 1971a ). Parameters of the wing imaginal disc development of Drosophila melanogaster . Dev. Biol . 26...