... be redirected when discs regenerate after injury or when key selector genes are misregulated. Here, we show that when Polycomb expression is reduced, the wing selector gene vestigial is ectopically activated. This leads to the inappropriate formation of the Vestigial–Scalloped complex, which forces the eye...

...) is required for the epithelial re-ordering that occurs during Drosophila pupal wing proximo-distal elongation. We identify the exocyst component Sec15 as a RASSF8 interactor. Loss of RASSF8 elicits cytoplasmic accumulation of Sec15 and Rab11-containing vesicles. These vesicles also contain the nectin-like...

... urchins and frogs. Here, we demonstrate that Polycomb group (PcG) proteins maintain Drosophila eye specification by suppressing the activation of alternative fate choices. The loss of PcG in the developing eye results in a cellular reprogramming event in which the eye is redirected to a wing fate...

... neuregulin-like called vein ( vn ). Here, we used mutant combinations and gene replacement to determine the constraints of ligand specificity in development. Mutant analysis revealed extensive ligand redundancy in embryogenesis and wing development. Surprisingly, we found that the essential role of vn...

... of planar cell polarity (PCP) is at present unclear. Here, we investigated the role of Rabenosyn-5 (Rbsn-5), an evolutionarily conserved effector of the small GTPase Rab5, in the development of Drosophila wing epithelium. We found that Rbsn-5 regulates endocytosis at the apical side of the wing epithelium...

... that these defects are caused by loss of cald activity. * Author for correspondence (e-mail: [email protected] ) 9 5 2006 © 2006. 2006 Insulin pathway Growth Wing Drosophila One of the most obvious differences between animals, even in the same systematic group, e.g...

... of strong dachs mutations, report the cloning of the dachs gene, characterize the localization of Dachs protein, and investigate the relationship between Dachs and the Fat pathway. Mutation of dachs reduces, but does not abolish, the growth of legs and wings. dachs encodes an unconventional myosin...

... wing, MAPK-mediated signaling is required both for patterning and for cell proliferation, although the mechanism of this differential control is not fully understood. Here, we show that phosphorylated MAPK (pMAPK) is held in the cytoplasm in differentiating larval and pupal wing vein cells, and we show...

...Jonathan D. Zirin; Richard S. Mann Secreted signaling molecules such as Wingless (Wg) and Decapentaplegic(Dpp) organize positional information along the proximodistal (PD) axis of the Drosophila wing imaginal disc. Responding cells activate different downstream targets depending on the combination...

...Ken-ichi Kimura; Akitoshi Kodama; Yosihiro Hayasaka; Takumi Ohta At the last step of metamorphosis in Drosophila , the wing epidermal cells are removed by programmed cell death during the wing spreading behavior after eclosion. The cell death was accompanied by DNA fragmentation demonstrated...

... cells maintain a spatial relationship even after the separation of their lineages. The peripodial membrane plays a significant role during the regional subdivision of the wing disc into presumptive wing, notum and hinge. The Egfr/Ras pathway mediates this function of the peripodial membrane...

...Karen Lunde; Jennifer L. Trimble; Annabel Guichard; Kirsten A. Guss; Ulrich Nauber; Ethan Bier The adjacent knirps ( kni ) and knirps-related ( knrl ) genes encode functionally related zinc finger transcription factors that collaborate to initiate development of the second longitudinal wing vein...

...Jun Wu; Stephen M. Cohen The wing imaginal disc comprises the primordia of the adult wing and the dorsal thoracic body wall. During second larval instar, the wing disc is subdivided into distinct domains that correspond to the presumptive wing and body wall. Early activity of the signaling protein...

.... ( 1997 ). Evolutionary origin of insect wings from ancestral gills. Nature 385 , 627 -630. Balkaschina, E. J. ( 1929 ). Ein Fall der Erbhomoeosis (die Genovariation “Aristapedia”) bei Drosophila melanogaster. Wilhelm Roux Arch. EntwMech. Org . 115 , 448 -463. Bishop, S. A., Klein, T...

...Robert P. Ray; Kristi A. Wharton The Drosophila BMP5/6/7/8 homolog, glass bottom boat ( gbb ), has been shown to be involved in proliferation and vein patterning in the wing disk. To better understand the roles for gbb in wing development, as well as its relationship with the Drosophila BMP2/4...

...Marco Milán; Ulrich Weihe; Stanley Tiong; Welcome Bender; Stephen M. Cohen Drosophila limbs develop from imaginal discs that are subdivided into compartments. Dorsal-ventral subdivision of the wing imaginal disc depends on apterous activity in dorsal cells. Apterous protein is expressed in dorsal...

.... In contrast with this activation model, experiments with the vertebrate homologue of Su(H), CBF1, suggest that, in vertebrates, Nintra converts CBF1 from a repressor into an activator. Here we have assessed the role of Su(H) in Notch signalling during the development of the wing of Drosophila . Our results...

...Fernando Roch; Michael Akam ABSTRACT The Drosophila haltere is a much reduced and specialised hind wing, which functions as a balance organ. Ultrabithorax (Ubx) is the sole Hox gene responsible for the differential development of the fore-wing and haltere in Drosophila . Previous work...

...Thomas Klein; Alfonso Martinez Arias The vestigial ( vg ) gene of Drosophila plays a central role in the development and patterning of the wing: loss of vestigial results in failures in wing development and ectopic expression of vestigial leads to the development of ectopic wings. The wing-specific...

...Raghavendra Nagaraj; Amanda T. Pickup; Robert Howes; Kevin Moses; Matthew Freeman; Utpal Banerjee Growth and patterning of the Drosophila wing disc depends on the coordinated expression of the key regulatory gene vestigial both in the Dorsal-Ventral (D/V) boundary cells and in the wing pouch. We...