... with genetic analysis and electron tomography, we have identified the Actin-related protein (Arp) 2/3 complex as the major actin nucleator involved in the initiation of dendrite branchlet formation, under the control of the activator WAVE and of the small GTPase Rac1. Transient recruitment of an Arp2/3...

... of the primitive streak (PS) by WNT. In the pluripotent state, E-cadherin (E-CAD) transduces boundary forces to focus WNT signaling to the colony border. Following application of WNT ligand, E-CAD mediates a front or wave of epithelial-to-mesenchymal (EMT) conversion analogous to PS extension in an embryo...

... regulates neuronal polarization through the WAVE complex . J. Neurosci. 30 , 6930 - 6943 . Timmons L. , Court D. L. , Fire A. ( 2001 ). Ingestion of bacterially expressed dsRNAs can produce specific and potent genetic interference in Caenorhabditis elegans . Gene 263 , 103...

... spatial cues to direct arm extension. We provide the first evidence that the guanine-nucleotide exchange factor UNC-73/Trio,members of the WAVE actin-polymerization complex, and a homolog of the focal adhesion complex can function downstream of UNC-40 to direct membrane extension. Our work is the first...

...Andrew S. Rakeman; Kathryn V. Anderson Dynamic cell movements and rearrangements are essential for the generation of the mammalian body plan, although relatively little is known about the genes that coordinate cell movement and cell fate. WAVE complexes are regulators of the actin cytoskeleton...

...Dipanwita Basu; Salah El-Din El-Assal; Jie Le; Eileen L. Mallery; Daniel B. Szymanski The WAVE complex is an essential regulator of actin-related protein (ARP)2/3-dependent actin filament nucleation and cell shape change in migrating cells. Although the composition of the WAVE complex is well...