... to the balance between stem cell replenishment and cell recruitment into new organs. In angiosperms, the transcription factor WUSCHEL (WUS) promotes stem cell proliferation in the central zone of the SAM. WUS forms a negative feedback loop with a signaling pathway activated by CLAVATA3 (CLV3). In the periphery...

... cells, and the transcription factor WUSCHEL, expressed in the underlying organising centre. clv3 mutant meristems display massive overgrowth, which is thought to be caused by stem cell overproliferation, although it is unknown how uncontrolled stem cell divisions lead to this altered morphology. Here...

..., WUSCHEL and AGAMOUS . The phenotype was also dependent on growth conditions. Together, these results highlight the surprisingly plastic nature of stem cell maintenance in plants and its dependence on Paf1c. * These authors contributed equally to this work ‡ Authors for correspondence...

... in the epidermal and internal tissue layers. However, our understanding of how the functions of these stem cells are coordinated across tissue layers so stem cells can behave as a single population remains limited. WUSCHEL (WUS) functions as a master regulator of stem cell activity. Here, we show that loss...

... and organization in the Arabidopsis shoot apical meristem. MIR166 Organizing center Phyllotaxis Stem cells WUSCHEL In plants, all above-ground organs develop post-embryonically from a small group of pluripotent stem cells that reside at the shoot tips in a highly organized structure called...

... and flowers. These organs arise from shoot apical meristems whose homeostasis depends on coordination between self-renewal of stem cells and their differentiation into organ founder cells. This coordination is stringently controlled by the central transcription factor WUSCHEL (WUS), which is both necessary...

... . Bioinformatics 21 , 3448 - 3449 . 10.1093/bioinformatics/bti551 Mayer K. F. X. , Schoof H. , Haecker A. , Lenhard M. , Jürgens G. , Laux T. ( 1998 ). Role of WUSCHEL in regulating stem cell fate in the Arabidopsis shoot meristem . Cell 95 , 805 - 815 . 10.1016...

... that mediate this homeostatic balance are not well understood. A homeodomain transcription factor WUSCHEL, expressed in the rib meristem (RM), located beneath the CZ, has been shown to provide nonautonomous cues for stem cell specification. By employing transient spatial manipulation and live imaging, we show...

... of the stem cells. We have undertaken a series of high-precision laser ablation and microsurgical tissue removal experiments to test the functions of different parts of the tomato meristem, and to reveal their interactions. Ablation of the central zone led to ectopic expression of the WUSCHEL gene...

... organ primordia. The homeobox genes WUSCHEL ( WUS ) and SHOOTMERISTEMLESS ( STM ) encode two major regulators of meristem formation and maintenance in Arabidopsis , yet their interaction in meristem regulation is presently unclear. Here, we have addressed this question using loss- and gain-of-function...

...Thomas Laux; Klaus F. X. Mayer; Jürgen Berger; Gerd Jürgens ABSTRACT Self perpetuation of the shoot meristem is essential for the repetitive initiation of shoot structures during plant devel-opment. In Arabidopsis shoot meristem maintenance is disrupted by recessive mutations in the WUSCHEL (WUS...