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Keywords: WNT signalling
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Journal Articles
Journal: Development
Development (2023) 150 (3): dev201352.
Published: 10 February 2023
... proteins. Although much focus has been on understanding intracellular Wnt signal transduction, the cellular machinery responsible for Wnt secretion became better understood only recently. After lipid modification by the acyl-transferase Porcupine, Wnt proteins bind their dedicated cargo protein Evi/Wntless...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (16): dev200312.
Published: 15 August 2022
...Paula Murphy; Chris Armit; Bill Hill; Shanmugasundaram Venkataraman; Patrick Frankel; Richard A. Baldock; Duncan R. Davidson ABSTRACT Wnt signalling controls patterning and differentiation across many tissues and organs of the developing embryo through temporally and spatially restricted expression...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (15): dev185421.
Published: 14 August 2020
.... Summary: SNARE-dependent secondary secretion via Rab4 recycling endosomes plays an important role in coordinating long-range extracellular levels of the hydrophobic morphogen Wnt/Wingless. Wnt secretion Wnt signalling Endosomal sorting Morphogen trafficking Cell behaviour and growth...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (15): dev185421.
Published: 14 August 2020
.... , Karaulanov , E. , Berger , B. S. , Huang , Y.-L. and Niehrs , C. ( 2014 ). Mitotic Wnt signaling promotes protein stabilization and regulates cell size . Mol. Cell   54 , 663 - 674 . 10.1016/j.molcel.2014.04.014 Albrecht , L. V. , Ploper , D. , Tejeda-Muñoz , N...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2020) 147 (7): dev183186.
Published: 6 April 2020
... of the terminal asymmetric divisions of neuronal progenitors. C. elegans Neuron Asymmetric division Polarity Wnt signalling The nervous system of animals is composed of a high diversity of neuronal subtypes. In vertebrates and invertebrates, neurons are often generated by asymmetric divisions...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2020) 147 (7): dev183186.
Published: 6 April 2020
... of the terminal asymmetric divisions of neuronal progenitors. C. elegans Neuron Asymmetric division Polarity Wnt signalling Centre National de la Recherche Scientifique 10.13039/501100004794 Institut National de la Santé et de la Recherche Médicale 10.13039/501100001677...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (10): dev176073.
Published: 15 May 2019
... of Biologists Ltd 2019 Summary: This Review describes the trafficking mechanisms proposed to mediate the extracellular transport of Wnt proteins and discusses how they contribute to Wnt dispersal. Cytoneme Exosome Secretion Signal transduction Wnt signalling Wnt trafficking The Wnt...
Journal Articles
Journal: Development
Development (2019) 146 (7): dev172858.
Published: 5 April 2019
... for the morphogenesis of the head and brain. The loss of function of the Wnt inhibitor Dkk1 results in elevated Wnt activity, loss of ectoderm lineage attributes from the anterior epiblast, and the posteriorisation of anterior germ layer tissue towards the mesendoderm. The modulation of Wnt signalling may therefore...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (7): dev172858.
Published: 5 April 2019
... for the morphogenesis of the head and brain. The loss of function of the Wnt inhibitor Dkk1 results in elevated Wnt activity, loss of ectoderm lineage attributes from the anterior epiblast, and the posteriorisation of anterior germ layer tissue towards the mesendoderm. The modulation of Wnt signalling may therefore...
Includes: Supplementary data
Journal Articles
In collection:
Advocacy
Journal: Development
Development (2018) 145 (12): dev165902.
Published: 26 June 2018
.... M. , Patel , B. B. , Bahrami-Nejad , Z. , Travaglini , K. J. , et al. ( 2016 ). Comparative genetic screens in human cells reveal new regulatory mechanisms in WNT signaling . Elife   5 , 410 . 10.7554/eLife.21459 Lickert , H. , Kispert , A. , Kutsch , S...
Journal Articles
Journal Articles
Journal: Development
Development (2016) 143 (11): 1914–1925.
Published: 1 June 2016
... to target genomic loci serves as the hallmark of canonical Wnt signalling, mechanisms controlling stage- or tissue-specific transcriptional responses remain elusive. Here, a direct comparison of genome-wide occupancy of β-catenin with a stage-matched Wnt-regulated transcriptome reveals that only a subset...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (11): 2069–2079.
Published: 1 June 2015
... that accompanies the formation of the anterior mesendoderm, in part through regulation of Pcdh7 expression. LHX1 also regulates, in the anterior mesendoderm, the transcription of genes encoding negative regulators of WNT signalling, such as Dkk1 , Hesx1 , Cer1 and Gsc. Embryos carrying mutations in Pcdh7...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2014) 141 (24): 4794–4805.
Published: 15 December 2014
... differentiation by promoting Wnt/β-catenin signalling in the developing forebrain. In addition, we show that Fezf2 promotes activation of Wnt/β-catenin signalling by repressing the expression of two negative regulators of Wnt signalling, namely lhx2 and lhx9 . Our findings suggest that Fezf2 plays an essential...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2014) 141 (6): 1209–1221.
Published: 15 March 2014
... EpiSCs are biased towards mesoderm and endoderm fates while retaining pluripotency. The acquisition of primitive streak characteristics by self-renewing EpiSCs is mediated by endogenous Wnt signalling. Elevation of Wnt activity promotes restriction towards primitive streak-associated lineages...
Includes: Supplementary data
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Journal Articles
Journal Articles