..., 1991 ; Cable et al., 1995 ; Huizinga et al., 1995 ). However, Kit expression cannot be followed in embryos homozygous for a null mutation in the c- kit gene. homologous recombination ES cells W locus c- kit proto-oncogene stem cell factor receptor tyrosine kinase mouse W lacZ / W...

.... neurite outgrowth neurotrophic factor stem cell factor c- kit receptor dorsal root ganglion Sl locus W locus nerve growth factor The c- kit receptor tyrosine kinase is encoded by the W locus in mice ( Chabot et al., 1988 ; Geissler et al., 1988 ). The ligand for c- kit receptor...

...Kazuya Yoshinaga; Satomi Nishikawa; Minetaro Ogawa; Shin-Ichi Hayashi; Takahiro Kunisada; Toyoaki Fujimoto; Shin-Ichi Nishikawa ABSTRACT Recent studies have shown that the dominant white spotting (W) locus encodes the proto-oncogene c-kit , a member of the tyrosine kinase receptor family. One...

...Katya Manova; Karl Nocka; Peter Besmer; Rosemary F. Bachvarova Recently, it has been shown that the c-kit proto-oncogene is encoded at the white spotting ( W) locus in mice. Mutations of this gene cause depletion of germ cells, some hematopoietic cells and melanocytes. In order to define further...