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Keywords: Vsx2
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Journal Articles

Functional analysis of the Vsx2 super-enhancer uncovers distinct cis -regulatory circuits controlling Vsx2 expression during retinogenesis

Fuyun Bian, Marwa Daghsni, Fangfang Lu, Silvia Liu, Jeffrey M. Gross, Issam Aldiri
Journal: Development
Development (2022) 149 (15): dev200642.
https://doi.org/10.1242/dev.200642
Published: 8 August 2022
...Fuyun Bian; Marwa Daghsni; Fangfang Lu; Silvia Liu; Jeffrey M. Gross; Issam Aldiri ABSTRACT Vsx2 is a transcription factor essential for retinal proliferation and bipolar cell differentiation, but the molecular mechanisms underlying its developmental roles are unclear. Here, we have profiled VSX2...
View article titled, Functional analysis of the <span class="search-highlight">Vsx2</span> super-enhancer uncovers distinct cis -regulatory circuits controlling <span class="search-highlight">Vsx2</span> expression during retinogenesis
Open the PDF for Functional analysis of the <span class="search-highlight">Vsx2</span> super-enhancer uncovers distinct cis -regulatory circuits controlling <span class="search-highlight">Vsx2</span> expression during retinogenesis in another window
Includes: Supplementary data
Journal Articles

Simultaneous deletion of Prdm1 and Vsx2 enhancers in the retina alters photoreceptor and bipolar cell fate specification, yet differs from deleting both genes

Noah B. Goodson, Michael A. Kaufman, Ko U. Park, Joseph A. Brzezinski, IV
Journal: Development
Development (2020) 147 (13): dev190272.
https://doi.org/10.1242/dev.190272
Published: 3 July 2020
...Noah B. Goodson; Michael A. Kaufman; Ko U. Park; Joseph A. Brzezinski, IV ABSTRACT The transcription factor OTX2 is required for photoreceptor and bipolar cell formation in the retina. It directly activates the transcription factors Prdm1 and Vsx2 through cell type-specific enhancers. PRDM1...
View article titled, Simultaneous deletion of Prdm1 and <span class="search-highlight">Vsx2</span> enhancers in the retina alters photoreceptor and bipolar cell fate specification, yet differs from deleting both genes
Open the PDF for Simultaneous deletion of Prdm1 and <span class="search-highlight">Vsx2</span> enhancers in the retina alters photoreceptor and bipolar cell fate specification, yet differs from deleting both genes in another window
Includes: Supplementary data
Journal Articles

RPE specification in the chick is mediated by surface ectoderm-derived BMP and Wnt signalling

Jörg Steinfeld, Ichie Steinfeld, Nicola Coronato, Meggi-Lee Hampel, Paul G. Layer, Masasuke Araki, Astrid Vogel-Höpker
Journal: Development
Development (2013) 140 (24): 4959–4969.
https://doi.org/10.1242/dev.096990
Published: 15 December 2013
... into a dorsal Mitf - and ventral Vsx2 -expressing domain, Bmp4 and Bmp7 transcripts are still detected throughout the surface ectoderm ( Crossley et al., 2001 ; Müller et al., 2007 ). This suggests that another signal is involved in progressively restricting Mitf expression to the dorsal ov. The Wnt...
View article titled, RPE specification in the chick is mediated by surface ectoderm-derived BMP and Wnt signalling
Open the PDF for RPE specification in the chick is mediated by surface ectoderm-derived BMP and Wnt signalling in another window
Includes: Supplementary data