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Keywords: Vg1
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Journal Articles
Journal: Development
Development (2013) 140 (8): 1819–1829.
Published: 15 April 2013
..., the current study identifies and characterizes Vg1/Nodal signaling (henceforth referred to as ‘Nodal-like signaling’) as a novel regulator of IM formation. Excess Nodal-like signaling at gastrulation stages resulted in expansion of the IM at the expense of the adjacent paraxial mesoderm, whereas inhibition...
Journal Articles
Journal: Development
Development (2012) 139 (22): 4232–4238.
Published: 15 November 2012
..., but different vertebrates differ in how this activity is positioned. In chick, the earliest known asymmetry is posterior expression of the TGFβ-related factor Vg1, close to the future Nodal expression domain. Here we show that the transcription factor Gata2 is expressed anteriorly before this stage. Gata2...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (20): 3649–3664.
Published: 15 October 2007
... critically requires autoregulation by Nodal and signaling by the maternal TGF-β Univin. We show that Univin is related to Vg1, that both Nodal and Univin signal through Alk4/5/7, and that zygotic expression of univin , like that of nodal , is dependent on SoxB1 function and Tcf/β-catenin signaling. This work...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (19): 3777–3786.
Published: 1 October 2006
...Kunimasa Ohta; Sei Kuriyama; Tatsuya Okafuji; Ryu Gejima; Shin-ichi Ohnuma; Hideaki Tanaka Three classes of signaling molecule, VG1, WNT and BMP, play crucial roles in axis formation in the chick embryo. Although VG1 and WNT signals have a pivotal function in inducing the primitive streak...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (1): 15–20.
Published: 1 January 2006
...Bilge Birsoy; Matt Kofron; Kyle Schaible; Chris Wylie; Janet Heasman Xenopus Vg1, a transforming growth factor β (Tgfβ)family member, was one of the first maternally localized mRNAs identified in vertebrates. Its restriction to the vegetal pole of the egg made it the ideal candidate...
Journal Articles
Journal: Development
Development (2005) 132 (3): 591–602.
Published: 1 February 2005
... hemisphere of the oocyte; second, it is required for the endogenous mesoderm inducing activity of vegetal cells before gastrulation; and third, it has substrate-specific activity, cleaving Xnr1, Xnr2, Xnr3 and Vg1, but not Xnr5,Derrière or ActivinB pro-proteins. We conclude that maternal XPACE4 plays...
Journal Articles
Journal: Development
Development (2004) 131 (14): 3381–3390.
Published: 15 July 2004
... pathways that initiate primitive streak formation and the mechanisms that ensure that only a single axis normally forms. As reported previously, an ectopic primitive streak can be induced by misexpression of Vg1 in the marginal zone. We now show that Vg1 induces an inhibitor that travels across the embryo...
Journal Articles
Journal: Development
Development (2002) 129 (1): 37–52.
Published: 1 January 2002
...-catenin (Wnt proteins), MAPK (tyrosine kinase receptors/FGF), Smad1 (BMP proteins) and Smad2 (Nodal/activin/Vg1). We have determined semi-quantitatively the distribution of these components at 18 consecutive stages in Xenopus development, from early blastula to tailbud stages, by immunofluorescence...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2001) 128 (15): 2915–2927.
Published: 1 August 2001
... the PMZ is removed, the embryo can initiate axis formation from another part of the remaining marginal zone. Chick Vg1 can mimic the axis-inducing ability of the PMZ, but only when misexpressed somewhere within the marginal zone. We have investigated the properties that define the marginal zone...