... the evolution of developmental and organismal complexity. Here, we review how animal models for core spliceosome components have provided insights into the role of splicing in vertebrate development, with a specific focus on neuronal, neural crest and skeletal development. To this end, we also discuss relevant...

... and a small fraction of genomic regions is hypomethylated. Previous studies have implicated hypomethylated regions in gene regulation, but their functions in vertebrate development remain elusive. To address this issue, we generated epigenomic profiles that include base-resolution DNA methylomes and histone...

... Vertebrate development Mouse Hox genes are key regulators of embryonic development ( Krumlauf, 1994 ; Pearson et al., 2005 ). Genes of this family are typically organized in genomic clusters, although some exceptions to this rule have been described recently ( Duboule, 2007 ). Whereas invertebrates...

... for correspondence (e-mail: [email protected]) 30 08 2000 © 2000 by Company of Biologists 2000 FGF Pax6 Neural tube Patterning Vertebrate development Chick In the developing vertebrate central nervous system, the regionalised expression of homeobox genes helps to define distinct...

..., Weyertal 121, 50931 Köln, Germany †† Present address: Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA 05 03 1996 © 1996 by Company of Biologists 1996 zebrafish ENU mutagenesis ‘Tübingen’ mutants’ vertebrate development...

... microscope and kinetic study . J. Embryol. exp. Morph . 87 , 215 – 247 . Copyright © 1988 by Company of Biologists 1988 paired box genes segmentation vertebrate development intervertebral disks The genetic mechanisms controlling segmentation during mammalian embryogenesis still...