...Akiteru Maeno; Rina Koita; Hidemichi Nakazawa; Renka Fujii; Kazuya Yamada; Sae Oikawa; Taisei Tani; Mizuki Ishizaka; Koumi Satoh; Atsuki Ishizu; Takumi Sugawara; Urara Adachi; Morimichi Kikuchi; Norimasa Iwanami; Masaru Matsuda; Akinori Kawamura ABSTRACT The vertebral column is a characteristic...

...Keiji Inohaya; Yoshiro Takano; Akira Kudo The floor plate is a key organizer that controls the specification of neurons in the central nervous system. Here, we show a new role of the floor plate: segmental pattern formation of the vertebral column. Analysis of a spontaneous medaka mutant, fused...

... Developmental genetics Posterior prevalence Vertebral column Primaxial/abaxial © 2007. 2007 12 6 2007 * Author for correspondence (e-mail: [email protected] ) References Bachiller, D., Macias, A., Duboule, D. and Morata, G. ( 1994 ). Conservation of a functional hierarchy...

... functions to promote Bmp4 signaling during mouse head development. * Author for correspondence (e-mail: [email protected] ) 13 10 2003 © 2004. 2004 Twisted gastrulation Bmp Tgfβ Chordin Tolloid Crossveinless Holoprosencephaly Vertebral column Growth factors...

...Patrick Smits; Véronique Lefebvre The notochord has major roles in vertebral column formation: indirectly by inducing sclerotome cell differentiation; and directly by forming the nucleus pulposus of intervertebral discs. Sox5 and Sox6 encode Sry-related HMG box transcription factors that act...

...Elizabeth M. Morin-Kensicki; Ellie Melancon; Judith S. Eisen The segmental heritage of all vertebrates is evident in the character of the vertebral column. And yet, the extent to which direct translation of pattern from the somitic mesoderm and de novo cell and tissue interactions pattern...

.... * Author for correspondence (e-mail: [email protected] ) 26 02 2001 19 04 2001 © 2001 by Company of Biologists 2001 Paralogous Hox genes Vertebral column Axial skeleton Vertebrae Ribs Mouse Functional redundancy Hoxb8 Hoxc8 Hoxd8 Transformation...

... mesenchymal condensation normally occurs. At later stages, an increased number of cells undergoing apoptosis further reduces the area normally forming vertebrae and intervertebral discs. Our results reveal functional redundancy between Pax1 and Pax9 during vertebral column development and identify an early...

... mutation the whole Pax-1 locus is deleted, resulting in the complete absence of Pax-1 protein in these mice. The other two genotypes are interpreted as hypomorphs. We conclude that Pax-1 is necessary for normal vertebral column formation along the entire axis, although the severity of the phenotype...

... of the vertebral column. * To whom correspondence should be addressed 11 07 1988 © 1988 by Company of Biologists 1988 chick embryo heat shock segmentation anomaly clock and wavefront model vertebral column biochemical clock In vertebrate embryos, segmentation of the body...

...: both give rise to bone and cartilage of the vertebral column, as well as to intervertebral connective tissue. We suggest that the rostrocaudal subdivision serves to maintain the segmental arrangement when the mesenchymal sclerotome dissociates, so that the nervous system, vasculature and possibly...