... Ventricle FGF nkx2.5 Zebrafish Cardiac chamber development National Institutes of Health R01HL108599 R01HL158112 American Heart Association http://dx.doi.org/10.13039/100000968 21PRE827354 University of California-San Diego RG084137 The vertebrate heart...

... are not well understood. Here, we show that FGF signaling plays an essential part in enforcing ventricular identity. Loss of FGF signaling results in a gradual accumulation of atrial cells, a corresponding loss of ventricular cells, and the appearance of ectopic atrial gene expression within the ventricle...

... territory of the heart tube ( supplementary material Fig. S9 ). When using this strategy in wild-type embryos, photoconversion of Kaede in ventricular cardiomyocytes within the heart tube ( Fig. 9A-C ) always led to the detection of labeled cells within the ventricle, and not the atrium ( Fig. 9D-F...

...Brian R. Keegan; Dirk Meyer; Deborah Yelon Organogenesis requires the specification of a variety of cell types and the organization of these cells into a particular three-dimensional configuration. The embryonic vertebrate heart is organized into two major chambers, the ventricle and atrium, each...

...Eli Berdougo; Hope Coleman; Diana H. Lee; Didier Y. R. Stainier; Deborah Yelon The embryonic vertebrate heart is composed of two major chambers, a ventricle and an atrium, each of which has a characteristic size, shape and functional capacity that contributes to efficient circulation. Chamber...

... for correspondence (e-mail: [email protected] ) * These authors contributed equally to this work 9 7 2003 © 2003. 2003 Heart Atrium Ventricle RALDH2 Retinoic acid AMHC1 BMS493 Mouse Chicken Embryo Establishment of the circulation is a two-pronged process. First...

... not establish normal circulation, although vessel formation is only mildly affected. In contrast, heart development, in particular of the ventricle, is severely abnormal in acerebellar mutants. Several findings argue that Fgf8 has a direct function in development of cardiac precursor cells: fgf8 is expressed...

... from complete absence of outflow tract and ventricles to hearts with reduced ventricles expressing both SMyHC3-HAP and ventricular markers. Blockade of RA synthesis with disulfiram inhibited RA-induced transcription and produced hearts lacking the atrial chamber. This study defines a novel marker...

... class of mutations affecting the formation of brain ventricles. Analysis of this class reveals the requirement of a functional cardiovascular system for ventricle enlargement during embryogenesis. Mutations in one locus lead to the formation of supernumerary primary neurons, a phenotype reminiscent...