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Keywords: Ventricle
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Journal Articles
Journal: Development
Development (2024) 151 (4): dev202183.
Published: 13 February 2024
... Ventricle FGF nkx2.5 Zebrafish Cardiac chamber development National Institutes of Health R01HL108599 R01HL158112 American Heart Association http://dx.doi.org/10.13039/100000968 21PRE827354 University of California-San Diego RG084137 The vertebrate heart...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (7): 1328–1338.
Published: 1 April 2017
... are not well understood. Here, we show that FGF signaling plays an essential part in enforcing ventricular identity. Loss of FGF signaling results in a gradual accumulation of atrial cells, a corresponding loss of ventricular cells, and the appearance of ectopic atrial gene expression within the ventricle...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (20): 4203–4213.
Published: 15 October 2013
... ( supplementary material Fig. S7 ), indicating the presence of SHF-derived cardiomyocytes in the ventricle. However, downregulated expression of ltbp3 , an SHF marker ( Zhou et al., 2011 ), in nkx2.5 mutant embryos ( supplementary material Fig. S8A ,C) suggests that there could be diminished contribution from...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (13): 3081–3091.
Published: 1 July 2004
...Brian R. Keegan; Dirk Meyer; Deborah Yelon Organogenesis requires the specification of a variety of cell types and the organization of these cells into a particular three-dimensional configuration. The embryonic vertebrate heart is organized into two major chambers, the ventricle and atrium, each...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2003) 130 (24): 6121–6129.
Published: 15 December 2003
...Eli Berdougo; Hope Coleman; Diana H. Lee; Didier Y. R. Stainier; Deborah Yelon The embryonic vertebrate heart is composed of two major chambers, a ventricle and an atrium, each of which has a characteristic size, shape and functional capacity that contributes to efficient circulation. Chamber...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2003) 130 (22): 5363–5374.
Published: 15 November 2003
... ), exposure of anterior cardiac precursors to RA at HH8-9 must serve a developmental program distinct from AP patterning. Expression of Raldh2 in ventricular precursors prior to fusion of cardiac primordia may activate RA-dependent pathways later in chicken ventricles. It remains to be established by fate...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2000) 127 (2): 225–235.
Published: 15 January 2000
... not establish normal circulation, although vessel formation is only mildly affected. In contrast, heart development, in particular of the ventricle, is severely abnormal in acerebellar mutants. Several findings argue that Fgf8 has a direct function in development of cardiac precursor cells: fgf8 is expressed...
Journal Articles
Journal: Development
Development (1999) 126 (12): 2677–2687.
Published: 15 June 1999
... from complete absence of outflow tract and ventricles to hearts with reduced ventricles expressing both SMyHC3-HAP and ventricular markers. Blockade of RA synthesis with disulfiram inhibited RA-induced transcription and produced hearts lacking the atrial chamber. This study defines a novel marker...
Journal Articles
Journal: Development
Development (1996) 123 (1): 165–178.
Published: 1 December 1996
... class of mutations affecting the formation of brain ventricles. Analysis of this class reveals the requirement of a functional cardiovascular system for ventricle enlargement during embryogenesis. Mutations in one locus lead to the formation of supernumerary primary neurons, a phenotype reminiscent...