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Keywords: Vegf
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Journal Articles
Journal: Development
Development (2023) 150 (7): dev201030.
Published: 11 April 2023
... endothelial growth factor (Vegf), Notch and cxcr4a signalling. Subsequently, veins produced veins in more proximal fin regions, transforming pre-existing artery-vein loops into a three-vessel pattern consisting of an artery and two veins. A distinct set of vascular plexuses formed at the base of the fin...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (10): dev180760.
Published: 27 May 2021
... identify a conserved role in the formation of the skeleton in both processes. Echinoderm Biomineralization Regulatory networks Signalling Vegf Recently, several studies have established the brittle star Amphiura filiformis ( Afi ) as an experimental system for skeleton formation in both...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (21): dev173674.
Published: 4 November 2019
... negative version of Vegfaa (dnVegfaa) in β-cells led to vascular and endocrine cell disruption with a minor impairment in β-cell function. In contrast, expression of a soluble isoform of Vegf receptor 1 (sFlt1) in β-cells blocked the formation of the pancreatic vasculature and drastically stunted glucose...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (14): dev151019.
Published: 20 July 2018
...Sinem Karaman; Veli-Matti Leppänen; Kari Alitalo ABSTRACT Vascular endothelial growth factors (VEGFs) are best known for their involvement in orchestrating the development and maintenance of the blood and lymphatic vascular systems. VEGFs are secreted by a variety of cells and they bind...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (13): 2249–2260.
Published: 1 July 2016
.... , Gerber , B. , Tschanz , S. A. , Buergy , R. , Blank , F. , Hlushchuk , R. and Djonov , V. ( 2010 ). VEGF-A promotes intussusceptive angiogenesis in the developing chicken chorioallantoic membrane . Microcirculation   17 , 447 - 457 . 10.1111/j.1549-8719.2010.00043.x...
Journal Articles
Journal: Development
Development (2016) 143 (3): 373–386.
Published: 1 February 2016
.... Endocardium Cardiac development Hemodynamics Bmp Krüppel-like factor 2 Vegf Mechanotransduction Zebrafish Mouse During cardiac tube formation, cardiogenic progenitor cells give rise to endocardial cells that undergo a unique process of vasculogenesis and assemble into a specialised endothelial...
Journal Articles
Journal: Development
Development (2016) 143 (2): 348–355.
Published: 15 January 2016
... the discrepancy between the in vitro and in vivo hypertrophic chondrocyte phenotypes revealed normal chondrocyte differentiation in c-Raf f/f ;ColII-Cre + mice and lack of compensatory increase in the expression of A-Raf and B-Raf. However, VEGF (Vegfa) immunoreactivity in the hypertrophic chondrocytes of c-Raf f...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (1): 147–159.
Published: 1 January 2016
... cells to enable intracerebral vascularization and proper expression of molecular markers associated with BBB formation. Additional studies with cultured endothelial cells suggest that, in other contexts, Reck impacts vascular biology via the vascular endothelial growth factor (VEGF) cascade. Together...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2014) 141 (7): 1480–1491.
Published: 1 April 2014
... of organs, but the mechanisms leading to this arrangement are incompletely understood. Here, we show that vascular endothelial growth factor (VEGF) signaling profoundly affects both vascularization and innervation of the pancreatic islet. In mature islets, nerves are closely associated with capillaries...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2013) 140 (24): 4881–4889.
Published: 15 December 2013
... no competing financial interests. 25 2 2013 12 9 2013 © 2013. Published by The Company of Biologists Ltd 2013 Wnt5 Sea urchin VEGF Ectoderm Specification In an embryo, tissue boundaries form when cells of two different gene regulatory states are juxtaposed...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (20): 4214–4225.
Published: 15 October 2013
...Ashrifia Adomako-Ankomah; Charles A. Ettensohn Growth factor signaling pathways provide essential cues to mesoderm cells during gastrulation in many metazoans. Recent studies have implicated the VEGF and FGF pathways in providing guidance and differentiation cues to primary mesenchyme cells (PMCs...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (12): 2632–2642.
Published: 15 June 2013
... endogenous VEGFA signalling. This response depends on expression of the VEGF receptor Flk1, driven by Fli1 and Gata2. Scl activation requires synergy between this VEGFA-controlled pathway and a VEGFA-independent pathway controlled by Fli1, Gata2 and Etv2/Etsrp/ER71, which also drives expression of the Scl...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (23): 4356–4365.
Published: 1 December 2012
... the manuscript with feedback from Y.M., Y.S. and A.J.G. Competing interests statement The authors declare no competing financial interests. 24 8 2012 © 2012. Published by The Company of Biologists Ltd 2012 Angiogenesis MicroRNA miR-1 miR-206 VEGF Secreted signaling...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (24): 5357–5368.
Published: 15 December 2011
... The authors declare no competing financial interests. 5 10 2011 © 2011. Cardiogenesis Flk1 (Kdr) Hemangioblasts Hematopoiesis VEGF Vasculogenesis Mouse Mesodermal cells give rise to blood, blood vessel, kidney, cardiac and skeletal muscle. These tissues...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (21): 4743–4752.
Published: 1 November 2011
..., VEGF-induced hypervascularization decreases pancreas size. The growth phenotype results from vascular restriction of pancreatic tip cell formation, lateral branching and differentiation of the pancreatic epithelium into endocrine and acinar cells. The effects are seen both in vivo and ex vivo...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (19): 4185–4191.
Published: 1 October 2011
... growth factor (VEGF) and class 3 semaphorin families through its extracellular domain, it also has a highly conserved cytoplasmic domain, which terminates in a SEA motif that binds the PDZ protein synectin/GIPC1/NIP. Previous studies in zebrafish embryos and tissue culture models raised the possibility...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (17): 3723–3733.
Published: 1 September 2011
... VEGF164 promotes the survival of migrating GnRH neurons by co-activating the ERK and AKT signalling pathways through NRP1. We also demonstrate that survival signalling relies on neuronal, but not endothelial, NRP1 expression and that it occurs independently of KDR, the main VEGF receptor in blood vessels...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (10): 2111–2120.
Published: 15 May 2011
... factor (VegfA). Here we present Flt1 (Vegf receptor 1) loss- and gain-of-function data in zebrafish showing that Flt1 regulates tip cell formation and arterial branching morphogenesis. Zebrafish embryos expressed soluble Flt1 (sFlt1) and membrane-bound Flt1 (mFlt1). In Tg(flt1 BAC :yfp) × Tg(kdrl:ras...
Includes: Multimedia, Supplementary data