... 2015 Summary: Cdc42 and its effectors Pak2/4 and N-WASP are required for organisation of the actin cytoskeleton during blood vessel development, both in filopodia and nascent cell-cell junctions. Cdc42 Vasculogenesis Blood vessel development F-actin VE-cadherin Filopodia Blood...

...Kyung Min Park; Sharon Gerecht The formation of vasculature is essential for tissue maintenance and regeneration. During development, the vasculature forms via the dual processes of vasculogenesis and angiogenesis, and is regulated at multiple levels: from transcriptional hierarchies and protein...

... The authors declare no competing financial interests. 5 10 2011 © 2011. Cardiogenesis Flk1 (Kdr) Hemangioblasts Hematopoiesis VEGF Vasculogenesis Mouse Mesodermal cells give rise to blood, blood vessel, kidney, cardiac and skeletal muscle. These tissues...

... T. L. , Paw B. , Brownlie A. J. , et al . ( 1998 ). The cloche and spadetail genes differentially affect hematopoiesis and vasculogenesis . Dev. Biol. 197 , 248 - 269 . Torres-Vazquez J. , Gitler A. D. , Fraser S. D. , Berk J. D. , Van N. P...

... μm. As migration of endothelial cells is crucial for sprouting in vasculogenesis and angiogenesis ( Schmidt et al., 2004 ), we determined this parameter in a modified Boyden chamber. We found decreased migration of PECAM-positive MAC-sorted β1 integrin −/− endothelial cells ( Fig. 6C...

... embryonic vasculogenesis and angiogenesis are incompletely understood. Here, we show that R-spondin 3(Rspo3), a member of a novel family of secreted proteins in vertebrates that activate Wnt/β-catenin signaling, plays a key role in these processes. In Xenopus embryos, morpholino antisense knockdown of Rspo3...

.... * Author for correspondence (e-mail: marlener@stanford.edu ) 2 7 2008 © 2008. 2008 Bmpr1a ( Alk3 ) Vasculogenesis Heart development Craniofacial development Matrix metalloproteinase (metallopeptidase) MMP2 MMP9 Smooth muscle cell proliferation Pericyte apoptosis SM22α...

... influenced the expression of genes regulating surfactant lipid and protein homeostasis, vasculogenesis, including Vegfa , and smooth muscle cell differentiation. KLF5 regulates genes controlling paracrine interactions during lung morphogenesis, as well as those regulating the maturation of the respiratory...

... the blood vessels and are critical for angiogenesis. The de novo differentiation of endothelial cells is known as vasculogenesis, whereas the growth of new blood vessels from pre-existing vessels is known as angiogenesis. To ascertain the function of c-myc in vascular development, we deleted c-myc...

..., the molecular underpinnings of these defects are poorly understood. To assess whether Myc indeed contributes to embryonic vasculogenesis we evaluated Myc function in Xenopus laevis embryogenesis. Here, we report that Xc-Myc is required for the normal assembly of endothelial cells into patent vessels during both...

... represents a replacement event or the initial establishment of the vascular endothelium. * Author for correspondence (e-mail: utigges@burnham.org ) 12 11 2007 © 2008. 2008 Vasculogenesis Pericyte Macrophage Endothelial cell Bone marrow progenitor Although most studies...

... are part of the instructive endodermal signal that triggers the assembly of the first primitive vessels in the mesoderm. We used a combination of genetic and in vitro culture methods to investigate the role of hedgehogs and their targets in murine extraembryonic vasculogenesis. We show that Bmps...

... the expression of Man1 and used a gene-trapped (GT) embryonic stem (ES) cell clone to derive mice with a functional mutation in the Man1 gene. We show that Man1 is essential for embryonic vasculogenesis and that the Man1 GT/GT mutation results in hyperactivation of some components in TGFβ signaling...

... studies indicate a crucial role for ALK3 in vessel remodeling, vessel integrity and endocardial cushion formation during the development of the circulation system. * Author for correspondence (e-mail: kchoi@wustl.edu ) 16 6 2006 © 2006. 2006 Hematopoiesis Vasculogenesis...

... /T C for all parameters examined, including allantoic elongation, cell number, mitotic index, cell death and vasculogenesis, the latter affecting the yolk sac as well. Despite being shorter than wild type, all T C / + allantoises ultimately grew far enough to fuse with the chorion. Thus...

...Chie Furuta; Hideo Ema; Shin-ichiro Takayanagi; Takunori Ogaeri; Daiji Okamura; Yasuhisa Matsui; Hiromitsu Nakauchi Vasculogenesis and hematopoiesis are thought to arise in hemangioblasts,the common progenitors of cells in vessels and in blood. This scheme was challenged by kinetic analysis...

... arteries and veins of all organs studied here. These data suggest the existence of a `vasculogenic zone' in the wall of adult human blood vessels,which may serve as a source for progenitor cells for postnatal vasculogenesis,contributing to tumor vascularization and local immune response. Cells...

..., it has been postulated to play a critical role in heart and vascular development. We show here, for the first time, that a null mutation of Hhex results in striking abnormalities of cardiac and vascular development which include: (1) defective vasculogenesis, (2)hypoplasia of the right ventricle, (3...

... of endothelial tubes, a process known as vasculogenesis. These first vessels generally form in mesoderm that is adjacent to endodermal tissue. Although specification of the angioblast lineage is independent of endoderm interactions, a signal from the endoderm is necessary for angioblasts to assemble...

... examined the formation of the primary vascular pattern during avian vasculogenesis. Five types of distinguishable endothelial cell motion are observed during formation of a vascular plexus: (1) global tissue deformations that passively convect endothelial cells; (2) vascular drift, a sheet-like medial...