... 2015 Summary: Cdc42 and its effectors Pak2/4 and N-WASP are required for organisation of the actin cytoskeleton during blood vessel development, both in filopodia and nascent cell-cell junctions. Cdc42 Vasculogenesis Blood vessel development F-actin VE-cadherin Filopodia Blood...

...Kyung Min Park; Sharon Gerecht The formation of vasculature is essential for tissue maintenance and regeneration. During development, the vasculature forms via the dual processes of vasculogenesis and angiogenesis, and is regulated at multiple levels: from transcriptional hierarchies and protein...

... and vasculogenesis in Flk-1-deficient mice . Nature 376 , 62 – 66 . van Noort M. , Clevers H. ( 2002 ). TCF transcription factors, mediators of Wnt-signaling in development and cancer . Dev. Biol. 244 , 1 – 8 . Winnier G. , Blessing M. , Labosky P. A. , Hogan B. L...

... ) Competing interests statement The authors declare no competing financial interests. 8 2 2011 © 2011. 2011 Basilar artery Central arteries Vasculogenesis Angiogenesis Chemokine Zebrafish Brain vascular disease has become a topic of intensive study. A thorough knowledge...

... returned to normal in the rescue clone (data not shown). As migration of endothelial cells is crucial for sprouting in vasculogenesis and angiogenesis ( Schmidt et al., 2004 ), we determined this parameter in a modified Boyden chamber. We found decreased migration of PECAM-positive MAC-sorted β1...

... embryonic vasculogenesis and angiogenesis are incompletely understood. Here, we show that R-spondin 3(Rspo3), a member of a novel family of secreted proteins in vertebrates that activate Wnt/β-catenin signaling, plays a key role in these processes. In Xenopus embryos, morpholino antisense knockdown of Rspo3...

... ) Vasculogenesis Heart development Craniofacial development Matrix metalloproteinase (metallopeptidase) MMP2 MMP9 Smooth muscle cell proliferation Pericyte apoptosis SM22α (transgelin, Tagln) Mouse Bone morphogenetic protein receptors (BMPRs) are members of the transforming growth factor β...

... influenced the expression of genes regulating surfactant lipid and protein homeostasis, vasculogenesis, including Vegfa , and smooth muscle cell differentiation. KLF5 regulates genes controlling paracrine interactions during lung morphogenesis, as well as those regulating the maturation of the respiratory...

... the blood vessels and are critical for angiogenesis. The de novo differentiation of endothelial cells is known as vasculogenesis, whereas the growth of new blood vessels from pre-existing vessels is known as angiogenesis. To ascertain the function of c-myc in vascular development, we deleted c-myc...

..., the molecular underpinnings of these defects are poorly understood. To assess whether Myc indeed contributes to embryonic vasculogenesis we evaluated Myc function in Xenopus laevis embryogenesis. Here, we report that Xc-Myc is required for the normal assembly of endothelial cells into patent vessels during both...

... 2007 © 2008. 2008 Vasculogenesis Pericyte Macrophage Endothelial cell Bone marrow progenitor Progenitor cells from the adult bone marrow, peripheral circulation and local tissues make substantial contributions to microvascularization,especially during tumor growth and other...

... are part of the instructive endodermal signal that triggers the assembly of the first primitive vessels in the mesoderm. We used a combination of genetic and in vitro culture methods to investigate the role of hedgehogs and their targets in murine extraembryonic vasculogenesis. We show that Bmps...

... 2007 © 2007. 2007 Nuclear envelope Vasculogenesis Man1 ( Lemd3 ) TGFβ The nucleus of mammalian cells is bounded by the nuclear envelope (NE) and underlying nuclear lamina. The NE consists of an inner nuclear membrane (INM)and outer nuclear membrane (ONM). The two membranes...

...<0.05. * Author for correspondence (e-mail: [email protected] ) 16 6 2006 © 2006. 2006 Hematopoiesis Vasculogenesis Endocardial cushion FLK1 (KDR) ALK3 (BMPR1A) SMAD4 Mouse The establishment of the circulatory system including blood, vasculature and the heart...

... was the reason for the failed vasculogenesis. To decrease overall allantoic cell number,wild-type EHF-stage allantoises were microsurgically bisected transversely(T1/2; Fig. 5B , part h) or longitudinally, either in direct register with the embryonic axis [axial halves (A1/2); Fig. 5B , part j], or at 90...

...Chie Furuta; Hideo Ema; Shin-ichiro Takayanagi; Takunori Ogaeri; Daiji Okamura; Yasuhisa Matsui; Hiromitsu Nakauchi Vasculogenesis and hematopoiesis are thought to arise in hemangioblasts,the common progenitors of cells in vessels and in blood. This scheme was challenged by kinetic analysis...

... arteries and veins of all organs studied here. These data suggest the existence of a `vasculogenic zone' in the wall of adult human blood vessels,which may serve as a source for progenitor cells for postnatal vasculogenesis,contributing to tumor vascularization and local immune response. Cells...

..., it has been postulated to play a critical role in heart and vascular development. We show here, for the first time, that a null mutation of Hhex results in striking abnormalities of cardiac and vascular development which include: (1) defective vasculogenesis, (2)hypoplasia of the right ventricle, (3...

... of endothelial tubes, a process known as vasculogenesis. These first vessels generally form in mesoderm that is adjacent to endodermal tissue. Although specification of the angioblast lineage is independent of endoderm interactions, a signal from the endoderm is necessary for angioblasts to assemble...

... examined the formation of the primary vascular pattern during avian vasculogenesis. Five types of distinguishable endothelial cell motion are observed during formation of a vascular plexus: (1) global tissue deformations that passively convect endothelial cells; (2) vascular drift, a sheet-like medial...