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Keywords: Vasculogenesis
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Journal Articles
Journal: Development
Development (2015) 142 (17): 3058–3070.
Published: 1 September 2015
... 2015 Summary: Cdc42 and its effectors Pak2/4 and N-WASP are required for organisation of the actin cytoskeleton during blood vessel development, both in filopodia and nascent cell-cell junctions. Cdc42 Vasculogenesis Blood vessel development F-actin VE-cadherin Filopodia Blood...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (14): 2760–2769.
Published: 15 July 2014
...Kyung Min Park; Sharon Gerecht The formation of vasculature is essential for tissue maintenance and regeneration. During development, the vasculature forms via the dual processes of vasculogenesis and angiogenesis, and is regulated at multiple levels: from transcriptional hierarchies and protein...
Journal Articles
Journal: Development
Development (2011) 138 (24): 5357–5368.
Published: 15 December 2011
... The authors declare no competing financial interests. 5 10 2011 © 2011. Cardiogenesis Flk1 (Kdr) Hemangioblasts Hematopoiesis VEGF Vasculogenesis Mouse Mesodermal cells give rise to blood, blood vessel, kidney, cardiac and skeletal muscle. These tissues...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (9): 1705–1715.
Published: 1 May 2011
... T. L. , Paw B. , Brownlie A. J. , et al . ( 1998 ). The cloche and spadetail genes differentially affect hematopoiesis and vasculogenesis . Dev. Biol. 197 , 248 - 269 . Torres-Vazquez J. , Gitler A. D. , Fraser S. D. , Berk J. D. , Van N. P...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (6): 993–1002.
Published: 15 March 2010
... μm. As migration of endothelial cells is crucial for sprouting in vasculogenesis and angiogenesis ( Schmidt et al., 2004 ), we determined this parameter in a modified Boyden chamber. We found decreased migration of PECAM-positive MAC-sorted β1 integrin −/− endothelial cells ( Fig. 6C...
Journal Articles
Journal: Development
Development (2008) 135 (22): 3655–3664.
Published: 15 November 2008
... embryonic vasculogenesis and angiogenesis are incompletely understood. Here, we show that R-spondin 3(Rspo3), a member of a novel family of secreted proteins in vertebrates that activate Wnt/β-catenin signaling, plays a key role in these processes. In Xenopus embryos, morpholino antisense knockdown of Rspo3...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2008) 135 (15): 2563–2572.
Published: 1 August 2008
... influenced the expression of genes regulating surfactant lipid and protein homeostasis, vasculogenesis, including Vegfa , and smooth muscle cell differentiation. KLF5 regulates genes controlling paracrine interactions during lung morphogenesis, as well as those regulating the maturation of the respiratory...
Journal Articles
Journal: Development
Development (2008) 135 (14): 2467–2477.
Published: 15 July 2008
... the blood vessels and are critical for angiogenesis. The de novo differentiation of endothelial cells is known as vasculogenesis, whereas the growth of new blood vessels from pre-existing vessels is known as angiogenesis. To ascertain the function of c-myc in vascular development, we deleted c-myc...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (11): 1903–1911.
Published: 1 June 2008
..., the molecular underpinnings of these defects are poorly understood. To assess whether Myc indeed contributes to embryonic vasculogenesis we evaluated Myc function in Xenopus laevis embryogenesis. Here, we report that Xc-Myc is required for the normal assembly of endothelial cells into patent vessels during both...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2007) 134 (20): 3753–3761.
Published: 15 October 2007
... are part of the instructive endodermal signal that triggers the assembly of the first primitive vessels in the mesoderm. We used a combination of genetic and in vitro culture methods to investigate the role of hedgehogs and their targets in murine extraembryonic vasculogenesis. We show that Bmps...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (7): 1385–1395.
Published: 1 April 2007
... the expression of Man1 and used a gene-trapped (GT) embryonic stem (ES) cell clone to derive mice with a functional mutation in the Man1 gene. We show that Man1 is essential for embryonic vasculogenesis and that the Man1 GT/GT mutation results in hyperactivation of some components in TGFβ signaling...
Journal Articles
Journal Articles
Journal: Development
Development (2006) 133 (15): 2947–2959.
Published: 1 August 2006
... /T C for all parameters examined, including allantoic elongation, cell number, mitotic index, cell death and vasculogenesis, the latter affecting the yolk sac as well. Despite being shorter than wild type, all T C / + allantoises ultimately grew far enough to fuse with the chorion. Thus...
Journal Articles
Journal: Development
Development (2006) 133 (14): 2771–2779.
Published: 15 July 2006
...Chie Furuta; Hideo Ema; Shin-ichiro Takayanagi; Takunori Ogaeri; Daiji Okamura; Yasuhisa Matsui; Hiromitsu Nakauchi Vasculogenesis and hematopoiesis are thought to arise in hemangioblasts,the common progenitors of cells in vessels and in blood. This scheme was challenged by kinetic analysis...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (8): 1543–1551.
Published: 15 April 2006
... arteries and veins of all organs studied here. These data suggest the existence of a `vasculogenic zone' in the wall of adult human blood vessels,which may serve as a source for progenitor cells for postnatal vasculogenesis,contributing to tumor vascularization and local immune response. Cells...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2004) 131 (17): 4371–4380.
Published: 1 September 2004
... of endothelial tubes, a process known as vasculogenesis. These first vessels generally form in mesoderm that is adjacent to endodermal tissue. Although specification of the angioblast lineage is independent of endoderm interactions, a signal from the endoderm is necessary for angioblasts to assemble...
Journal Articles
Journal: Development
Development (2004) 131 (12): 2887–2897.
Published: 15 June 2004
... examined the formation of the primary vascular pattern during avian vasculogenesis. Five types of distinguishable endothelial cell motion are observed during formation of a vascular plexus: (1) global tissue deformations that passively convect endothelial cells; (2) vascular drift, a sheet-like medial...
Includes: Multimedia, Supplementary data