... of our observed phenotypes, whole kidney RNA-seq revealed disruptions to genes and programs associated with stromal cells, vasculature and differentiating nephrons. Together, our findings highlight the significance of Ntn1 to proper vascularization and kidney development. Whole kidneys were collected...

... of the zebrafish cerebral vasculature in 3D remains highly challenging. Here, we describe and test an image analysis workflow for 3D quantification of the total or regional zebrafish brain vasculature, called zebrafish vasculature quantification (ZVQ). It provides the first landmark- or object-based vascular inter...

..., and understanding the interactions between the vasculature and the islets may allow for therapeutic modulation in disease conditions. Using live imaging in two models of vascular disruption in zebrafish, we identified two distinct roles for the pancreatic vasculature. At larval stages, expression of a dominant...

... of the whole vascular network, head vasculature and tail vasculature over development. Our multi-sample platform demonstrates effective upgrades to conventional single-sample imaging platforms and paves the way for diverse quantitative long-term imaging studies. References Adams , R.H. and Alitalo...

...@nipgr.ac.in ) Competing interests The authors declare no competing or financial interests. © 2016. Published by The Company of Biologists Ltd 2016 Summary: This Review discusses how developmental features, such as plant architecture, leaf features and vasculature architecture...

... of lymphatic vessels from pre-existing vasculature) during embryonic development, tissue regeneration and tumor progression. The recently identified secreted protein CCBE1 is indispensible for lymphangiogenesis during development. The role of CCBE1 orthologs is highly conserved in zebrafish, mice and humans...

... to test the hypothesis that Notch signaling regulates pericyte coverage of brain blood vessels during development. To do so, we used zebrafish because the relatively small and simple brain vasculature facilitates quantification of pericytes and assessment of cell division and survival. We show...

... they are unable to form biliary tubes, revealing an instructive role of the vasculature in liver development. These findings uncover the cellular basis for the defining feature of AGS, identify mesenchymal Jag1-dependent and -independent stages of duct development, and provide mechanistic information for the role...

...Michael Ilegems; Véronique Douet; Marlyse Meylan-Bettex; Magalie Uyttewaal; Lukas Brand; John L. Bowman; Pia A. Stieger Class III HD-ZIP and KANADI gene family members have complementary expression patterns in the vasculature and their gain-of-function and loss-of-function mutants have...

... defects in cotyledon vein patterning and internode elongation leading to a characteristic broomhead-like phenotype. Histological analyses revealed an increased amount of vascular tissue, most notably xylem and lignified sclerenchyma, indicating a role for APC/C in plant vasculature development...

...Sudha P. Mudumana; Dirk Hentschel; Yan Liu; Aleksandr Vasilyev; Iain A. Drummond The kidney and vasculature are intimately linked both functionally and during development, when nephric and blood/vascular progenitor cells occupy adjacent bands of mesoderm in zebrafish and frog embryos. Developmental...

..., Graduate School of Science, The University of Tokyo, Tokyo, 113-0033, Japan 2 6 2007 © 2007. 2007 Arabidopsis Root pattern Symmetry Vasculature Multicellular organisms must coordinate division and expansion of the constituent cell types of each tissue to ensure organized...

... transcripts are broadly and dynamically expressed at later stages, but surprisingly mutant embryos display quite restricted tissue defects. Blimp1/Prdm1 (Blimp-1) Mouse Branchial arches Vasculature Primordial germ cells Current models suggest that programmed cell growth and differentiation...

... separate cell populations, the chondrocytes, the osteoblasts and the vasculature, each of which is a direct target of hedgehog signaling. * Author for correspondence (e-mail: jhelms@stanford.edu ) 16 12 2004 ©2005. 2005 Renal capsule transplantation Lineage analysis X-gal Null...

..., A. and Crabtree, G. R. ( 2001 ). Signals Transduced by Ca 2+ /Calcineurine and NFATc3/c4 pattern the developing vasculature. Cell 105 , 863 -875. Hellström, M., Kaln, M., Lindahl, P., Abramsson, A. and Betsholtz, C. ( 1999 ). Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells...

..., and it has been proposed that its essential function may be exerted in adjacent mesenchymal cells. We have generated mice in which ephrinB2 is specifically deleted in the endothelium and endocardium of the developing vasculature and heart. We find that such a vascular-specific deletion of ephrinB2 results...

... of contraction. The mutations identified in this screen point to discrete and critical steps in the formation and function of the heart and vasculature. ‡ Author for correspondence * Present address: Department of Biochemistry and Biophysics and Program in Developmental Biology, University...