... membranes, resulting in pathological blood–brain barrier integrity. Angiogenesis Extracellular matrix Brain microenvironment Blood vessel Vascular smooth muscle cell Astrocyte Pericyte Megalencephalic leukoencephalopathy with subcortical cysts 1 National Institute of Neurological...

... targeting to investigate the defects underlying the Lkb1 -/- phenotype. Endothelium-restricted deletion of Lkb1 led to embryonic death at E12.5 with a loss of vascular smooth muscle cells (vSMCs) and vascular disruption. Transforming growth factor beta(TGFβ) pathway activity was reduced in Lkb1 -deficient...

... plate mesoderm. A detailed understanding of the ontogeny of vascular smooth muscle cells(SMCs), and the morphological events that lead to their induction, is crucial for unraveling the molecular mechanisms that regulate their differentiation and for evaluating the importance of SMC origin...

...Mats Hellström; Mattias Kalén; Per Lindahl; Alexandra Abramsson; Christer Betsholtz ABSTRACT Development of a vascular system involves the assembly of two principal cell types – endothelial cells and vascular smooth muscle cells/pericytes (vSMC/PC) – into many different types of blood vessels. Most...