... capillaries and were observed in larger artery segments as they expanded. The dynamic and specific endothelial cell behaviors captured in this study reveal how sensitive endothelial cells are to changes in blood flow and how such responses drive vascular remodeling. For blood flow analysis, ε-Globin-GFP...

... module in the regulation of embryonic angiogenesis, which terminates sprouting to prevent excessive loop formation and stabilize the vascular network. Fig. 10. The involvement of S1P 1 in vascular remodeling. A model illustrating the regulatory role of S1P 1 , which acts to fine-tune...

... and endothelial cells. Brg1 fl/fl :Tie2-Cre + embryos die at midgestation from anemia, as mutant primitive erythrocytes fail to transcribe embryonicα- and β-globins, and subsequently undergo apoptosis. Additionally,vascular remodeling of the extraembryonic yolk sac is abnormal in Brg1 fl/fl :Tie2-Cre + embryos...

...) βsuperfamily signaling by interacting with receptor-associated Smads. However,the in vivo roles of Man1 have not been fully characterized. Here, we show that Man1 regulates vascular remodeling by analyzing Man1 -deficient embryos lacking the Smad interacting domain. Man1 -deficient embryos die at midgestation...

..., a hallmark of human placentation. * Author for correspondence (e-mail: [email protected] ) 7 7 2005 ©2005. 2005 Placenta Cytotrophoblast Vascular remodeling Chemokines EPHB4 Ephrin B2 Human Pregnancy During pregnancy, the placenta establishes a physical connection...